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    NPIPB3 nuclear pore complex interacting protein family member B3 [ Homo sapiens (human) ]

    Gene ID: 23117, updated on 5-Aug-2018

    Summary

    Official Symbol
    NPIPB3provided by HGNC
    Official Full Name
    nuclear pore complex interacting protein family member B3provided by HGNC
    Primary source
    HGNC:HGNC:28989
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NPIP; NPIPB; NPIPB5; NPIPL3; KIAA0220L
    Expression
    Ubiquitous expression in skin (RPKM 36.9), bone marrow (RPKM 26.9) and 24 other tissues See more

    Genomic context

    See NPIPB3 in Genome Data Viewer
    Location:
    16p12.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (21402129..21425378, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (21413455..21436658, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene crystallin mu Neighboring gene CRYM antisense RNA 1 Neighboring gene sorting nexin 29 pseudogene 1 Neighboring gene uncharacterized LOC100190986 Neighboring gene SMG1 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of nuclear pore complex interacting protein-like 3 (NPIPL3; KIAA0220L) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ17456, FLJ45371, FLJ54505, FLJ58661, FLJ79358, FLJ98670, KIAA0220, MGC70907, MGC105000

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    nuclear pore complex-interacting protein family member B3
    Names
    KIAA0220-like protein
    PI-3-kinase-related kinase SMG-1 isoform 1 homolog
    nuclear pore complex-interacting protein B type
    nuclear pore complex-interacting protein-like 3
    protein pps22-1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130464.3NP_569731.2  nuclear pore complex-interacting protein family member B3

      Status: VALIDATED

      Source sequence(s)
      AK294452, BC036263, BQ950195, DC309942
      Conserved Domains (3) summary
      pfam06409
      Location:41302
      NPIP; Nuclear pore complex interacting protein (NPIP)
      pfam16496
      Location:10321123
      SWIRM-assoc_2; SWIRM-associated domain at the N-terminal
      cl17068
      Location:141
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

      Range
      21402129..21425378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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