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    MAPRE3 microtubule associated protein RP/EB family member 3 [ Homo sapiens (human) ]

    Gene ID: 22924, updated on 2-Oct-2018

    Summary

    Official Symbol
    MAPRE3provided by HGNC
    Official Full Name
    microtubule associated protein RP/EB family member 3provided by HGNC
    Primary source
    HGNC:HGNC:6892
    See related
    Ensembl:ENSG00000084764 MIM:605788; Vega:OTTHUMG00000097067
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EB3; RP3; EBF3; EBF3-S
    Summary
    The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in brain (RPKM 45.3), testis (RPKM 13.7) and 20 other tissues See more
    Orthologs

    Genomic context

    See MAPRE3 in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (26970371..27027219)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27193525..27250087)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CDKN2A interacting protein N-terminal like pseudogene 2 Neighboring gene dihydropyrimidinase like 5 Neighboring gene uncharacterized LOC100129724 Neighboring gene transmembrane protein 214 Neighboring gene AGBL5 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cyclin-dependent protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of microtubule plus-end binding IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein localization TAS
    Traceable Author Statement
    more info
    PubMed 
    protein localization to microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein localization to microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of microtubule polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    microtubule-associated protein RP/EB family member 3
    Names
    APC binding protein
    EB1 protein family member 3
    end-binding protein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303050.1NP_001289979.1  microtubule-associated protein RP/EB family member 3

      See identical proteins and their annotated locations for NP_001289979.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AB025186, AC013472, BC011557, BM560331, HY011071
      Consensus CDS
      CCDS1731.1
      UniProtKB/Swiss-Prot
      Q9UPY8
      Conserved Domains (1) summary
      cl26556
      Location:16279
      EB1; EB1-like C-terminal motif
    2. NM_012326.3NP_036458.2  microtubule-associated protein RP/EB family member 3

      See identical proteins and their annotated locations for NP_036458.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AB025186, AC013472, BC011557, DC417465
      Consensus CDS
      CCDS1731.1
      UniProtKB/Swiss-Prot
      Q9UPY8
      Related
      ENSP00000233121.2, OTTHUMP00000122582, ENST00000233121.6, OTTHUMT00000214183
      Conserved Domains (1) summary
      cl26556
      Location:16279
      EB1; EB1-like C-terminal motif

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      26970371..27027219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711967.4XP_006712030.1  microtubule-associated protein RP/EB family member 3 isoform X1

      See identical proteins and their annotated locations for XP_006712030.1

      UniProtKB/Swiss-Prot
      Q9UPY8
      Related
      ENSP00000383915.3, OTTHUMP00000200909, ENST00000405074.7
      Conserved Domains (1) summary
      cl26556
      Location:16264
      EB1; EB1-like C-terminal motif
    2. XM_017003597.1XP_016859086.1  microtubule-associated protein RP/EB family member 3 isoform X1

      UniProtKB/Swiss-Prot
      Q9UPY8
      Conserved Domains (1) summary
      cl26556
      Location:16264
      EB1; EB1-like C-terminal motif
    3. XM_011532700.1XP_011531002.1  microtubule-associated protein RP/EB family member 3 isoform X1

      See identical proteins and their annotated locations for XP_011531002.1

      UniProtKB/Swiss-Prot
      Q9UPY8
      Related
      ENSP00000385715.1, OTTHUMP00000200911, ENST00000402218.1, OTTHUMT00000324726
      Conserved Domains (1) summary
      cl26556
      Location:16264
      EB1; EB1-like C-terminal motif
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