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    Dennd1a DENN/MADD domain containing 1A [ Mus musculus (house mouse) ]

    Gene ID: 227801, updated on 19-Feb-2019

    Summary

    Official Symbol
    Dennd1aprovided by MGI
    Official Full Name
    DENN/MADD domain containing 1Aprovided by MGI
    Primary source
    MGI:MGI:2442794
    See related
    Ensembl:ENSMUSG00000035392
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    connecdenn; 6030446I19Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 10.2), adrenal adult (RPKM 9.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dennd1a in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (37798990..38287384, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (37654510..38142904, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene spermatid perinuclear RNA binding protein Neighboring gene zinc finger protein 609 pseudogene Neighboring gene microRNA 5128 Neighboring gene crumbs family member 2 Neighboring gene predicted gene, 46736 Neighboring gene predicted gene 27197 Neighboring gene LIM homeobox protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC38995

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Rab GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Rab GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Rab guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Rab guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rab guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endocytic recycling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of Rab protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-coated vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DENN domain-containing protein 1A
    Names
    connecdenn 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362973.1NP_001349902.1  DENN domain-containing protein 1A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL805959, AL928810, AL929186, AL929238
      Conserved Domains (4) summary
      smart00801
      Location:305371
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:95273
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:991
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cl26464
      Location:6921018
      Atrophin-1; Atrophin-1 family
    2. NM_001362977.1NP_001349906.1  DENN domain-containing protein 1A isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon in the 3' end compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AK137530, AL805959, AL929186
      Conserved Domains (4) summary
      smart00801
      Location:273339
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:63241
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:2659
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cl26464
      Location:617943
      Atrophin-1; Atrophin-1 family
    3. NM_001362978.1NP_001349907.1  DENN domain-containing protein 1A isoform 4 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon in the 3' end compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AL805959, AL928810, AL929186, AL929238
      Conserved Domains (3) summary
      smart00801
      Location:233299
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:27201
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl26464
      Location:577903
      Atrophin-1; Atrophin-1 family
    4. NM_146122.3NP_666234.3  DENN domain-containing protein 1A isoform 2

      See identical proteins and their annotated locations for NP_666234.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK137530, AL805959, AL929186, BQ444119, CX563166
      Consensus CDS
      CCDS16007.1
      UniProtKB/Swiss-Prot
      Q8K382
      Related
      ENSMUSP00000099848.3, ENSMUST00000102787.9
      Conserved Domains (3) summary
      smart00801
      Location:305371
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:95273
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:991
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      37798990..38287384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498001.3XP_006498064.1  DENN domain-containing protein 1A isoform X4

      Conserved Domains (3) summary
      smart00801
      Location:275341
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:65243
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:1461
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    2. XM_006498002.3XP_006498065.1  DENN domain-containing protein 1A isoform X5

      Conserved Domains (3) summary
      smart00801
      Location:273339
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:63241
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:2659
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    3. XM_006498000.3XP_006498063.1  DENN domain-containing protein 1A isoform X3

      Conserved Domains (3) summary
      smart00801
      Location:278344
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:95246
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:991
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    4. XM_006497998.3XP_006498061.1  DENN domain-containing protein 1A isoform X1

      Conserved Domains (3) summary
      smart00801
      Location:305371
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:95273
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:991
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    5. XM_011239087.1XP_011237389.1  DENN domain-containing protein 1A isoform X8

      Conserved Domains (2) summary
      smart00801
      Location:233299
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:27201
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    6. XM_006498005.3XP_006498068.1  DENN domain-containing protein 1A isoform X9

      Conserved Domains (4) summary
      smart00801
      Location:273339
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:63241
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:2659
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cl26464
      Location:617943
      Atrophin-1; Atrophin-1 family
    7. XM_006497999.2XP_006498062.1  DENN domain-containing protein 1A isoform X2

      Conserved Domains (4) summary
      smart00801
      Location:305371
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:95273
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:991
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cl26464
      Location:6921018
      Atrophin-1; Atrophin-1 family
    8. XM_006498003.2XP_006498066.1  DENN domain-containing protein 1A isoform X6

      Conserved Domains (3) summary
      smart00801
      Location:305371
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:95273
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:991
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    9. XM_006498007.3XP_006498070.1  DENN domain-containing protein 1A isoform X10

      Conserved Domains (3) summary
      smart00801
      Location:233299
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:27201
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl26464
      Location:577903
      Atrophin-1; Atrophin-1 family
    10. XM_006498004.1XP_006498067.1  DENN domain-containing protein 1A isoform X7

      Conserved Domains (3) summary
      smart00801
      Location:306372
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:96274
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:1092
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    11. XM_017317481.1XP_017172970.1  DENN domain-containing protein 1A isoform X11

    12. XM_006498008.3XP_006498071.1  DENN domain-containing protein 1A isoform X12

      Conserved Domains (1) summary
      smart00801
      Location:46112
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
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