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    Nr1h2 nuclear receptor subfamily 1, group H, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 22260, updated on 12-Mar-2019

    Summary

    Official Symbol
    Nr1h2provided by MGI
    Official Full Name
    nuclear receptor subfamily 1, group H, member 2provided by MGI
    Primary source
    MGI:MGI:1352463
    See related
    Ensembl:ENSMUSG00000060601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UR; LXR; Unr; LXRB; NER1; OR-1; Unr2; RIP15; LXRBSV; LXRbeta; AI194859
    Expression
    Ubiquitous expression in adrenal adult (RPKM 100.3), duodenum adult (RPKM 94.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nr1h2 in Genome Data Viewer
    Location:
    7; 7 B3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (44549616..44553968, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (51805002..51809293, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene Spi-B transcription factor (Spi-1/PU.1 related) Neighboring gene polymerase (DNA directed), delta 1, catalytic subunit Neighboring gene microRNA 7053 Neighboring gene napsin A aspartic peptidase Neighboring gene predicted gene 15396 Neighboring gene predicted gene, 45981

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apolipoprotein A-I receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear receptor transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    retinoid X receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retinoid X receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cholesterol homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cholesterol homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cholesterol storage ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cold-induced thermogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of pinocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cholesterol efflux IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of high-density lipoprotein particle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of lipoprotein lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pancreatic juice secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of secretion of lysosomal enzymes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retinoic acid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    RNA polymerase II transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    oxysterols receptor LXR-beta
    Names
    LXR beta
    liver X receptor beta
    retinoid X receptor-interacting protein No.15
    ubiquitously-expressed nuclear receptor 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285517.1NP_001272446.1  oxysterols receptor LXR-beta isoform a

      See identical proteins and their annotated locations for NP_001272446.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      BC066025, BY197597
      Consensus CDS
      CCDS21211.1
      UniProtKB/Swiss-Prot
      Q60644
      Related
      ENSMUSP00000073188.5, ENSMUST00000073488.11
      Conserved Domains (2) summary
      cd06954
      Location:209444
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:58154
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    2. NM_001285518.1NP_001272447.1  oxysterols receptor LXR-beta isoform b

      See identical proteins and their annotated locations for NP_001272447.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3 and 4 both encode the same isoform (b).
      Source sequence(s)
      AK077620, AK134489, BC066025, BQ573162, BY197597
      Consensus CDS
      CCDS71947.1
      UniProtKB/Swiss-Prot
      Q60644
      UniProtKB/TrEMBL
      Q8BP65
      Related
      ENSMUSP00000103543.1, ENSMUST00000107910.7
      Conserved Domains (2) summary
      cd06954
      Location:206441
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:55151
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    3. NM_001285519.1NP_001272448.1  oxysterols receptor LXR-beta isoform b

      See identical proteins and their annotated locations for NP_001272448.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3 and 4 both encode the same isoform (b).
      Source sequence(s)
      AK077620, BC066025, BY197597
      Consensus CDS
      CCDS71947.1
      UniProtKB/Swiss-Prot
      Q60644
      UniProtKB/TrEMBL
      Q8BP65
      Related
      ENSMUSP00000103544.1, ENSMUST00000107911.7
      Conserved Domains (2) summary
      cd06954
      Location:206441
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:55151
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    4. NM_009473.3NP_033499.1  oxysterols receptor LXR-beta isoform a

      See identical proteins and their annotated locations for NP_033499.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC157653, AK077620, BC066025, BQ573162, BY197597
      Consensus CDS
      CCDS21211.1
      UniProtKB/Swiss-Prot
      Q60644
      UniProtKB/TrEMBL
      Q8BP65
      Related
      ENSMUSP00000126788.1, ENSMUST00000167197.7
      Conserved Domains (2) summary
      cd06954
      Location:209444
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:58154
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      44549616..44553968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540804.3XP_006540867.1  oxysterols receptor LXR-beta isoform X1

      See identical proteins and their annotated locations for XP_006540867.1

      UniProtKB/Swiss-Prot
      Q60644
      Related
      ENSMUSP00000103545.1, ENSMUST00000107912.7
      Conserved Domains (2) summary
      cd06954
      Location:209444
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:58154
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    2. XM_017322126.1XP_017177615.1  oxysterols receptor LXR-beta isoform X2

      Related
      ENSMUSP00000146466.1, ENSMUST00000208322.1
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