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    Ube2m ubiquitin-conjugating enzyme E2M [ Mus musculus (house mouse) ]

    Gene ID: 22192, updated on 8-Jun-2019

    Summary

    Official Symbol
    Ube2mprovided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2Mprovided by MGI
    Primary source
    MGI:MGI:108278
    See related
    Ensembl:ENSMUSG00000005575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UBC12; Ubc-rs2; 2510040H03Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 97.2), whole brain E14.5 (RPKM 66.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ube2m in Genome Data Viewer
    Location:
    7 A1; 7 7.73 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (13035120..13038275, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (13620587..13623619, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31649 Neighboring gene tripartite motif-containing 28 Neighboring gene charged multivesicular body protein 2A Neighboring gene myeloid zinc finger 1 Neighboring gene vomeronasal 1 receptor 85

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (3) 
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC25453, MGC37197

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    NEDD8 transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NEDD8 transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular protein modification process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein neddylation ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NEDD8-conjugating enzyme Ubc12
    Names
    NEDD8 carrier protein
    NEDD8 protein ligase
    UBC12 homolog, yeast
    ubiquitin C, related sequence 2
    NP_001161941.1
    NP_001230897.1
    NP_663553.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168469.2NP_001161941.1  NEDD8-conjugating enzyme Ubc12 isoform 2

      See identical proteins and their annotated locations for NP_001161941.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC121301
      Consensus CDS
      CCDS52024.1
      UniProtKB/TrEMBL
      G5E919
      Related
      ENSMUSP00000132604.2, ENSMUST00000165394.8
      Conserved Domains (1) summary
      pfam00179
      Location:271
      UQ_con; Ubiquitin-conjugating enzyme
    2. NM_001243968.1NP_001230897.1  NEDD8-conjugating enzyme Ubc12 isoform 3

      See identical proteins and their annotated locations for NP_001230897.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC121301
      Related
      ENSMUSP00000122638.1, ENSMUST00000125964.7
      Conserved Domains (1) summary
      pfam00179
      Location:7138
      UQ_con; Ubiquitin-conjugating enzyme
    3. NM_145578.3NP_663553.1  NEDD8-conjugating enzyme Ubc12 isoform 1

      See identical proteins and their annotated locations for NP_663553.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC121301
      Consensus CDS
      CCDS20825.1
      UniProtKB/Swiss-Prot
      P61082
      Related
      ENSMUSP00000005714.7, ENSMUST00000005714.13
      Conserved Domains (1) summary
      pfam00179
      Location:33168
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      13035120..13038275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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