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    Tpst1 protein-tyrosine sulfotransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 22021, updated on 12-Aug-2018

    Summary

    Official Symbol
    Tpst1provided by MGI
    Official Full Name
    protein-tyrosine sulfotransferase 1provided by MGI
    Primary source
    MGI:MGI:1298231
    See related
    Ensembl:ENSMUSG00000034118 Vega:OTTMUSG00000027866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R75054; Tango13a
    Expression
    Ubiquitous expression in bladder adult (RPKM 26.6), testis adult (RPKM 22.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tpst1 in Genome Data Viewer
    Location:
    5; 5 G1.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (130073326..130135734)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (130549196..130611602)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40334 Neighboring gene calcitonin gene-related peptide-receptor component protein Neighboring gene potassium channel tetramerisation domain containing 7 Neighboring gene RAB guanine nucleotide exchange factor (GEF) 1 Neighboring gene 60S ribosomal protein L21 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein-tyrosine sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-tyrosine sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-tyrosine sulfotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein-tyrosine sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    peptidyl-tyrosine sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-tyrosine sulfation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine sulfation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine sulfation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein-tyrosine sulfotransferase 1
    Names
    TPST-1
    tyrosylprotein sulfotransferase 1
    NP_001123948.1
    NP_038865.1
    XP_006504481.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130476.2NP_001123948.1  protein-tyrosine sulfotransferase 1

      See identical proteins and their annotated locations for NP_001123948.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI183198, AK150753, CJ046784
      Consensus CDS
      CCDS39293.1
      UniProtKB/Swiss-Prot
      O70281
      UniProtKB/TrEMBL
      Q4FK50
      Related
      ENSMUSP00000035614.8, OTTMUSP00000034991, ENSMUST00000040721.8, OTTMUST00000068988
      Conserved Domains (1) summary
      pfam13469
      Location:72261
      Sulfotransfer_3; Sulfotransferase family
    2. NM_013837.2NP_038865.1  protein-tyrosine sulfotransferase 1

      See identical proteins and their annotated locations for NP_038865.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF038008, AI183198
      Consensus CDS
      CCDS39293.1
      UniProtKB/Swiss-Prot
      O70281
      UniProtKB/TrEMBL
      Q4FK50
      Related
      ENSMUSP00000112571.1, OTTMUSP00000035003, ENSMUST00000118993.7, OTTMUST00000069018
      Conserved Domains (1) summary
      pfam13469
      Location:72261
      Sulfotransfer_3; Sulfotransferase family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      130073326..130135734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504418.2XP_006504481.1  protein-tyrosine sulfotransferase 1 isoform X1

      Conserved Domains (1) summary
      pfam13469
      Location:69257
      Sulfotransfer_3; Sulfotransferase family
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