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    Tgm3 transglutaminase 3, E polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 21818, updated on 19-Apr-2019

    Summary

    Official Symbol
    Tgm3provided by MGI
    Official Full Name
    transglutaminase 3, E polypeptideprovided by MGI
    Primary source
    MGI:MGI:98732
    See related
    Ensembl:ENSMUSG00000027401
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    we; TGE; TG E; TG(E); TGase E; TGase-3; AI893889
    Expression
    Biased expression in colon adult (RPKM 142.1), lung adult (RPKM 18.2) and 1 other tissue See more
    Orthologs

    Genomic context

    See Tgm3 in Genome Data Viewer
    Location:
    2; 2 F1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (129987794..130050399)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (129838110..129876135)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 35, opposite strand 1 Neighboring gene serine/threonine kinase 35 Neighboring gene predicted gene, 39933 Neighboring gene microRNA 6339 Neighboring gene expressed sequence AU015228 Neighboring gene transglutaminase 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    wellhaarig
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (4)  1 citation
    • Gene trapped (1) 
    • Targeted (4)  1 citation
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Homology

    Clone Names

    • MGC150256, MGC150257

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein-glutamine gamma-glutamyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-glutamine gamma-glutamyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein-glutamine gamma-glutamyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell envelope organization ISO
    Inferred from Sequence Orthology
    more info
     
    epidermis development TAS
    Traceable Author Statement
    more info
    PubMed 
    hair cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    keratinization IEA
    Inferred from Electronic Annotation
    more info
     
    peptide cross-linking IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptide cross-linking ISO
    Inferred from Sequence Orthology
    more info
     
    peptide cross-linking TAS
    Traceable Author Statement
    more info
    PubMed 
    protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    skin development TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    collagen-containing extracellular matrix HDA PubMed 
    cornified envelope TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein-glutamine gamma-glutamyltransferase E
    Names
    E polypeptide
    protein-glutamine-gamma-glutamyltransferase
    transglutaminase E
    transglutaminase-3
    NP_033400.2
    XP_006499214.1
    XP_011237739.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009374.3NP_033400.2  protein-glutamine gamma-glutamyltransferase E precursor

      See identical proteins and their annotated locations for NP_033400.2

      Status: VALIDATED

      Source sequence(s)
      AL808127
      Consensus CDS
      CCDS38240.1
      UniProtKB/Swiss-Prot
      Q08189
      Related
      ENSMUSP00000105928.2, ENSMUST00000110299.2
      Conserved Domains (3) summary
      smart00460
      Location:265357
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:5117
      Transglut_N; Transglutaminase family
      pfam00927
      Location:595691
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      129987794..130050399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239437.2XP_011237739.1  protein-glutamine gamma-glutamyltransferase E isoform X2

      Conserved Domains (3) summary
      smart00460
      Location:271363
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:11123
      Transglut_N; Transglutaminase family
      pfam00927
      Location:601697
      Transglut_C; Transglutaminase family, C-terminal ig like domain
    2. XM_006499151.3XP_006499214.1  protein-glutamine gamma-glutamyltransferase E isoform X1

      Conserved Domains (3) summary
      smart00460
      Location:276368
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:16128
      Transglut_N; Transglutaminase family
      pfam00927
      Location:606702
      Transglut_C; Transglutaminase family, C-terminal ig like domain
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