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    L2hgdh L-2-hydroxyglutarate dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 217666, updated on 31-Jan-2019

    Summary

    Official Symbol
    L2hgdhprovided by MGI
    Official Full Name
    L-2-hydroxyglutarate dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:2384968
    See related
    Ensembl:ENSMUSG00000020988
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BC016226
    Expression
    Ubiquitous expression in kidney adult (RPKM 10.3), heart adult (RPKM 6.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See L2hgdh in Genome Data Viewer
    Location:
    12; 12 C2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (69690436..69724874, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (70791423..70825861, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene SOS Ras/Rho guanine nucleotide exchange factor 2 Neighboring gene predicted gene, 31679 Neighboring gene chloride intracellular channel protein 4 pseudogene Neighboring gene retinol-binding protein 1 pseudogene Neighboring gene distal membrane arm assembly complex 2 like Neighboring gene cyclin-dependent kinase-like 1 (CDC2-related kinase) Neighboring gene microRNA 681

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC28775

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    (S)-2-hydroxy-acid oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    2-hydroxyglutarate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    2-hydroxyglutarate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    L-2-hydroxyglutarate dehydrogenase, mitochondrial
    Names
    duranin
    NP_663418.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145443.2NP_663418.1  L-2-hydroxyglutarate dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_663418.1

      Status: VALIDATED

      Source sequence(s)
      AK152450, AK168429, CJ087348
      Consensus CDS
      CCDS25953.1
      UniProtKB/Swiss-Prot
      Q91YP0
      Related
      ENSMUSP00000021370.8, ENSMUST00000021370.9
      Conserved Domains (2) summary
      PRK11728
      Location:62458
      PRK11728; hydroxyglutarate oxidase; Provisional
      cl21454
      Location:50449
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      69690436..69724874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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