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    Ptrh2 peptidyl-tRNA hydrolase 2 [ Mus musculus (house mouse) ]

    Gene ID: 217057, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ptrh2provided by MGI
    Official Full Name
    peptidyl-tRNA hydrolase 2provided by MGI
    Primary source
    MGI:MGI:2444848
    See related
    Ensembl:ENSMUSG00000072582
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bit1; PTH 2; CGI-147; A230072I16Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.6), liver E14 (RPKM 7.5) and 27 other tissues See more
    Orthologs

    Genomic context

    See Ptrh2 in Genome Data Viewer
    Location:
    11; 11 C
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (86683983..86692457)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (86497485..86505959)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 46289 Neighboring gene vacuole membrane protein 1 Neighboring gene 60S ribosomal protein L13a-like Neighboring gene clathrin, heavy polypeptide (Hc) Neighboring gene predicted gene, 42085 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 40

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    aminoacyl-tRNA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    aminoacyl-tRNA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peptidyl-tRNA hydrolase 2, mitochondrial
    NP_001092280.1
    NP_778169.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098810.3NP_001092280.1  peptidyl-tRNA hydrolase 2, mitochondrial isoform b

      See identical proteins and their annotated locations for NP_001092280.1

      Status: VALIDATED

      Source sequence(s)
      AA271949, AK031620, AK038888
      Consensus CDS
      CCDS48876.1
      UniProtKB/Swiss-Prot
      Q8R2Y8
      Related
      ENSMUSP00000103657.1, ENSMUST00000108022.7
      Conserved Domains (1) summary
      cd02430
      Location:67181
      PTH2; Peptidyl-tRNA hydrolase, type 2 (PTH2). Peptidyl-tRNA hydrolase (PTH) activity releases tRNA from the premature translation termination product peptidyl-tRNA, therefore allowing the tRNA and peptide to be reused in protein synthesis. PTH2 is present in ...
    2. NM_175004.3NP_778169.1  peptidyl-tRNA hydrolase 2, mitochondrial isoform a

      See identical proteins and their annotated locations for NP_778169.1

      Status: VALIDATED

      Source sequence(s)
      AL592222
      UniProtKB/Swiss-Prot
      Q8R2Y8
      Conserved Domains (1) summary
      cd02430
      Location:68182
      PTH2; Peptidyl-tRNA hydrolase, type 2 (PTH2). Peptidyl-tRNA hydrolase (PTH) activity releases tRNA from the premature translation termination product peptidyl-tRNA, therefore allowing the tRNA and peptide to be reused in protein synthesis. PTH2 is present in ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      86683983..86692457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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