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    Nle1 notchless homolog 1 [ Mus musculus (house mouse) ]

    Gene ID: 217011, updated on 31-Jan-2019

    Summary

    Official Symbol
    Nle1provided by MGI
    Official Full Name
    notchless homolog 1provided by MGI
    Primary source
    MGI:MGI:2429770
    See related
    Ensembl:ENSMUSG00000020692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nle; l11Jus1; l11Jus4; AL022765; BC018399
    Expression
    Ubiquitous expression in ovary adult (RPKM 23.0), thymus adult (RPKM 15.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nle1 in Genome Data Viewer
    Location:
    11; 11 C
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (82900768..82908445, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (82714270..82721897, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene RAD51 paralog D Neighboring gene fibronectin type III domain containing 8 Neighboring gene unc-45 myosin chaperone B Neighboring gene unc-45 myosin chaperone B, opposite strand Neighboring gene schlafen 5, opposite strand Neighboring gene schlafen 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC25690

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner cell mass cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ribosomal large subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    notchless protein homolog 1
    Names
    Notchless gene homolog
    novel WD40 repeat containing protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145431.2NP_663406.2  notchless protein homolog 1

      See identical proteins and their annotated locations for NP_663406.2

      Status: VALIDATED

      Source sequence(s)
      AI852473, AK141230, BX631936, BY149184
      Consensus CDS
      CCDS25152.1
      UniProtKB/Swiss-Prot
      Q8VEJ4
      UniProtKB/TrEMBL
      Q3URT5
      Related
      ENSMUSP00000099502.3, ENSMUST00000103213.9
      Conserved Domains (4) summary
      COG2319
      Location:107485
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:106484
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08154
      Location:1777
      NLE; NLE (NUC135) domain
      sd00039
      Location:159197
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      82900768..82908445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532975.2XP_006533038.1  notchless protein homolog 1 isoform X1

      Conserved Domains (4) summary
      COG2319
      Location:97298
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:106298
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08154
      Location:1777
      NLE; NLE (NUC135) domain
      sd00039
      Location:118154
      7WD40; WD40 repeat [structural motif]
    2. XM_006532976.2XP_006533039.1  notchless protein homolog 1 isoform X2

      Conserved Domains (4) summary
      COG2319
      Location:97272
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:105273
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08154
      Location:1777
      NLE; NLE (NUC135) domain
      sd00039
      Location:118154
      7WD40; WD40 repeat [structural motif]

    RNA

    1. XR_388409.2 RNA Sequence

    2. XR_879591.1 RNA Sequence

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