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    Tet2 tet methylcytosine dioxygenase 2 [ Mus musculus (house mouse) ]

    Gene ID: 214133, updated on 9-Oct-2018

    Summary

    Official Symbol
    Tet2provided by MGI
    Official Full Name
    tet methylcytosine dioxygenase 2provided by MGI
    Primary source
    MGI:MGI:2443298
    See related
    Ensembl:ENSMUSG00000040943 Vega:OTTMUSG00000055135
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ayu17-449; mKIAA1546; E130014J05Rik
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 4.9), CNS E11.5 (RPKM 4.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tet2 in Genome Data Viewer
    Location:
    3; 3 G3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (133463677..133545196, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (133126641..133207354, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor (GEF) 38 Neighboring gene pyrophosphatase (inorganic) 2 Neighboring gene predicted gene 49316 Neighboring gene predicted gene, 40153

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC37385

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
     
    iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    methylcytosine dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    methylcytosine dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    methylcytosine dioxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    methylcytosine dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    5-methylcytosine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    5-methylcytosine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    5-methylcytosine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA demethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    DNA demethylation TAS
    Traceable Author Statement
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    cytosine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemoglobin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H3-K4 trimethylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H3-K4 trimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    liver morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myeloid cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    myeloid progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein O-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    spleen development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    methylcytosine dioxygenase TET2
    Names
    probable methylcytosine dioxygenase TET2
    tet oncogene 2
    tet oncogene family member 2
    NP_001035490.2
    XP_006501344.1
    XP_006501346.1
    XP_006501349.1
    XP_006501350.1
    XP_011238370.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040400.2NP_001035490.2  methylcytosine dioxygenase TET2 isoform 1

      See identical proteins and their annotated locations for NP_001035490.2

      Status: VALIDATED

      Source sequence(s)
      AK129389, AK153311, BE137977, BF463367, DQ079067
      Consensus CDS
      CCDS51071.1
      UniProtKB/Swiss-Prot
      Q4JK59
      Related
      ENSMUSP00000096203.3, OTTMUSP00000072036, ENSMUST00000098603.7, OTTMUST00000136519
      Conserved Domains (1) summary
      pfam12851
      Location:12031340
      Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    2. NM_001346736.1NP_001333665.1  methylcytosine dioxygenase TET2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC120398, BF463367, DQ079067
      Consensus CDS
      CCDS84675.1
      UniProtKB/Swiss-Prot
      Q4JK59
      UniProtKB/TrEMBL
      A0A0G2JF55

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      133463677..133545196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501283.3XP_006501346.1  methylcytosine dioxygenase TET2 isoform X1

      See identical proteins and their annotated locations for XP_006501346.1

      UniProtKB/TrEMBL
      A0A0G2JF55
      Conserved Domains (1) summary
      pfam12851
      Location:12111348
      Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    2. XM_006501287.3XP_006501350.1  methylcytosine dioxygenase TET2 isoform X3

      Conserved Domains (1) summary
      pfam12851
      Location:12021339
      Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    3. XM_006501286.3XP_006501349.1  methylcytosine dioxygenase TET2 isoform X2

      Conserved Domains (1) summary
      pfam12851
      Location:12101347
      Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    4. XM_006501281.3XP_006501344.1  methylcytosine dioxygenase TET2 isoform X1

      Related
      ENSMUSP00000143029.1, OTTMUSP00000072038, ENSMUST00000196398.4, OTTMUST00000136527
      Conserved Domains (1) summary
      pfam12851
      Location:12111348
      Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    5. XM_011240068.2XP_011238370.1  methylcytosine dioxygenase TET2 isoform X1

      See identical proteins and their annotated locations for XP_011238370.1

      UniProtKB/TrEMBL
      A0A0G2JF55
      Conserved Domains (1) summary
      pfam12851
      Location:12111348
      Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145989.1: Suppressed sequence

      Description
      NM_145989.1: This RefSeq was permanently suppressed based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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