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    Eif2b1 eukaryotic translation initiation factor 2B, subunit 1 (alpha) [ Mus musculus (house mouse) ]

    Gene ID: 209354, updated on 12-Jan-2019

    Summary

    Official Symbol
    Eif2b1provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 2B, subunit 1 (alpha)provided by MGI
    Primary source
    MGI:MGI:2384802
    See related
    Ensembl:ENSMUSG00000029388
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EIF2BA; D5Ertd406e
    Summary
    This gene encodes the alpha subunit of the eukaryotic translation initiation factor complex 2B (eIF2B). The eIF2B complex is a heterodecamer comprised of two molecules each of alpha, beta, gamma, delta and epsilon subunits. The eIF2B complex is a critical regulator of protein synthesis acting as the guanine nucleotide exchange factor for eIF2 to enable the formation of ternary complex that is required for the initiation of mRNA translation. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in placenta adult (RPKM 18.0), liver E14 (RPKM 13.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Eif2b1 in Genome Data Viewer
    Location:
    5 F; 5 63.67 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (124570214..124579131, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (125020223..125029066, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene transmembrane p24 trafficking protein 2 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 Neighboring gene general transcription factor IIH, polypeptide 3 Neighboring gene tectonic family member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6458

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cellular metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    oligodendrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
     
    translation ISO
    Inferred from Sequence Orthology
    more info
     
    translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    eukaryotic translation initiation factor 2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    eukaryotic translation initiation factor 2B complex ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    translation initiation factor eIF-2B subunit alpha
    Names
    eIF-2B GDP-GTP exchange factor subunit alpha
    eukaryotic translation initiation factor 2B, subunit 1 (alpha, 26kDa)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145371.4NP_663346.1  translation initiation factor eIF-2B subunit alpha

      See identical proteins and their annotated locations for NP_663346.1

      Status: REVIEWED

      Source sequence(s)
      AK133695, DV649595
      Consensus CDS
      CCDS39282.1
      UniProtKB/Swiss-Prot
      Q99LC8
      UniProtKB/TrEMBL
      Q3UZR8
      Related
      ENSMUSP00000031334.8, ENSMUST00000031334.14
      Conserved Domains (2) summary
      COG1184
      Location:5305
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:17293
      IF-2B; Initiation factor 2 subunit family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      124570214..124579131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530275.3XP_006530338.1  translation initiation factor eIF-2B subunit alpha isoform X1

      Conserved Domains (2) summary
      COG1184
      Location:16198
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:17186
      IF-2B; Initiation factor 2 subunit family
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