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    EEF1G eukaryotic translation elongation factor 1 gamma [ Homo sapiens (human) ]

    Gene ID: 1937, updated on 7-Oct-2018

    Summary

    Official Symbol
    EEF1Gprovided by HGNC
    Official Full Name
    eukaryotic translation elongation factor 1 gammaprovided by HGNC
    Primary source
    HGNC:HGNC:3213
    See related
    Ensembl:ENSG00000254772 MIM:130593; Vega:OTTHUMG00000167567
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EF1G; GIG35
    Summary
    This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 1189.4), lymph node (RPKM 694.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See EEF1G in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (62559601..62573988, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62327073..62341460, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723765 Neighboring gene secretoglobin family 1A member 1 Neighboring gene AHNAK nucleoprotein Neighboring gene microRNA 6747 Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene metastasis associated 1 family member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 gamma (EEF1G), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 gamma (EEF1G), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Yeast two hybrid assay identifies the HIV-1 Nef-interacting protein translational elongation factor 1 PubMed
    nef Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 gamma (EEF1G), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 gamma (EEF1G), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    integrase gag-pol HIV-1 IN co-immunoprecipitates with eEF1G through an interaction with the viral RTCs PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human eukaryotic translation elongation factor 1 gamma (EEF1G) at amino acid residues 20-21 by the HIV-1 protease PubMed
    reverse transcriptase p51 subunit gag-pol HIV-1 RT p51 subunit co-immunoprecipitates with eEF1A through an interaction with the viral RTCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Eukaryotic Translation Elongation, organism-specific biosystem (from REACTOME)
      Eukaryotic Translation Elongation, organism-specific biosystemThe translation elongation cycle adds one amino acid at a time to a growing polypeptide according to the sequence of codons found in the mRNA. The next available codon on the mRNA is exposed in the a...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Translation, organism-specific biosystem (from REACTOME)
      Translation, organism-specific biosystemProtein synthesis is accomplished through the process of translation of an mRNA sequence into a polypeptide chain. This process can be divided into three distinct stages: initiation, elongation and ...
    • Translation Factors, organism-specific biosystem (from WikiPathways)
      Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cadherin binding HDA PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    response to virus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translational elongation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    colocalizes_with endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    membrane HDA PubMed 
    nucleus HDA PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    elongation factor 1-gamma
    Names
    EF-1-gamma
    PRO1608
    eEF-1B gamma
    pancreatic tumor-related protein
    translation elongation factor eEF-1 gamma chain

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001404.4NP_001395.1  elongation factor 1-gamma

      See identical proteins and their annotated locations for NP_001395.1

      Status: REVIEWED

      Source sequence(s)
      BC028179, BQ947806, X63526
      Consensus CDS
      CCDS44626.1
      UniProtKB/Swiss-Prot
      P26641
      UniProtKB/TrEMBL
      Q53YD7
      Related
      ENSP00000331901.4, OTTHUMP00000236167, ENST00000329251.4, OTTHUMT00000395047
      Conserved Domains (4) summary
      cd03181
      Location:91213
      GST_C_EF1Bgamma_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins
      cd03044
      Location:482
      GST_N_EF1Bgamma; GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of ...
      pfam00647
      Location:277381
      EF1G; Elongation factor 1 gamma, conserved domain
      cl25545
      Location:212278
      V-ATPase_G_2; Vacuolar (H+)-ATPase G subunit

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

      Range
      62559601..62573988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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