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    Pou4f2 POU domain, class 4, transcription factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 18997, updated on 9-Oct-2018

    Summary

    Official Symbol
    Pou4f2provided by MGI
    Official Full Name
    POU domain, class 4, transcription factor 2provided by MGI
    Primary source
    MGI:MGI:102524
    See related
    Ensembl:ENSMUSG00000031688 Vega:OTTMUSG00000039883
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Brn3b; Brn-3b; Brn-3.2; mBrn3-3R; Pou4f-rs1
    Expression
    Biased expression in whole brain E14.5 (RPKM 3.9), CNS E14 (RPKM 2.9) and 3 other tissues See more
    Orthologs

    Genomic context

    See Pou4f2 in Genome Data Viewer
    Location:
    8; 8 C1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (78433009..78436652, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (80956908..80960551, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39202 Neighboring gene tetratricopeptide repeat domain 29 Neighboring gene predicted gene 2225 Neighboring gene RNA binding motif protein, X-linked like-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    axon extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to cytokine stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to estradiol stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dorsal root ganglion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of amacrine cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular process controlling balance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of retinal ganglion cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retinal ganglion cell axon guidance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    retinal ganglion cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of sound IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    POU domain, class 4, transcription factor 2
    Names
    POU domain, class 4, transcription factor, related sequence 1
    brain-3B
    brain-specific homeobox/POU domain protein 3B

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138944.2NP_620394.2  POU domain, class 4, transcription factor 2

      See identical proteins and their annotated locations for NP_620394.2

      Status: PROVISIONAL

      Source sequence(s)
      AK087546
      Consensus CDS
      CCDS22429.1
      UniProtKB/Swiss-Prot
      Q63934
      Related
      ENSMUSP00000034115.2, OTTMUSP00000057927, ENSMUST00000034115.4, OTTMUST00000103645
      Conserved Domains (2) summary
      smart00352
      Location:252329
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:350403
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      78433009..78436652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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