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    Zfp638 zinc finger protein 638 [ Mus musculus (house mouse) ]

    Gene ID: 18139, updated on 2-Oct-2018

    Summary

    Official Symbol
    Zfp638provided by MGI
    Official Full Name
    zinc finger protein 638provided by MGI
    Primary source
    MGI:MGI:1203484
    See related
    Ensembl:ENSMUSG00000030016 Vega:OTTMUSG00000057474
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfml; Np220; Znf638; mNP220; AI323587
    Expression
    Broad expression in CNS E11.5 (RPKM 14.4), CNS E14 (RPKM 10.9) and 20 other tissues See more
    Orthologs

    Genomic context

    See Zfp638 in Genome Data Viewer
    Location:
    6; 6 C3
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (83867100..83986871)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (83864347..83936865)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L18 pseudogene Neighboring gene ribosomal protein S8 pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 33024 Neighboring gene dysferlin Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 638
    Names
    nuclear protein 220
    zinc finger matrin-like protein
    zinc finger, matrin-like

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166371.1NP_001159843.1  zinc finger protein 638 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the 3' coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC156283, BC076615
      Consensus CDS
      CCDS51823.1
      UniProtKB/Swiss-Prot
      Q61464
      Related
      ENSMUSP00000109466.3, OTTMUSP00000073893, ENSMUST00000113835.9, OTTMUST00000141351
      Conserved Domains (4) summary
      smart00451
      Location:12201252
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:9831056
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:879953
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      cl17169
      Location:676751
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. NM_001355284.1NP_001342213.1  zinc finger protein 638 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the 3' coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AC153607, AC156283, BC076615
      Conserved Domains (7) summary
      smart00451
      Location:18581890
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:9551028
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:851925
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      TIGR01649
      Location:8521152
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      pfam05110
      Location:549674
      AF-4; AF-4 proto-oncoprotein
      cl17169
      Location:676751
      RRM_SF; RNA recognition motif (RRM) superfamily
      cl26950
      Location:10431386
      LsmAD; LsmAD domain
    3. NM_001355285.1NP_001342214.1  zinc finger protein 638 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the 3' coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is shorter than isoform 1.
      Source sequence(s)
      AC153607, AC156283, BC076615
      Conserved Domains (7) summary
      smart00451
      Location:18241856
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:9551028
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:851925
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      TIGR01649
      Location:8521152
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      pfam05110
      Location:549674
      AF-4; AF-4 proto-oncoprotein
      cl17169
      Location:676751
      RRM_SF; RNA recognition motif (RRM) superfamily
      cl26950
      Location:10431386
      LsmAD; LsmAD domain
    4. NM_001355286.1NP_001342215.1  zinc finger protein 638 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1 and 5 encode the same protein (isoform 1).
      Source sequence(s)
      AC153607, AC156283, BC076615
      Conserved Domains (8) summary
      smart00451
      Location:18751907
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:10061079
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:902976
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      TIGR01649
      Location:9031203
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      pfam05110
      Location:549674
      AF-4; AF-4 proto-oncoprotein
      cl17169
      Location:676751
      RRM_SF; RNA recognition motif (RRM) superfamily
      cl26511
      Location:740900
      Neuromodulin_N; Gap junction protein N-terminal region
      cl26950
      Location:10941437
      LsmAD; LsmAD domain
    5. NM_008717.3NP_032743.2  zinc finger protein 638 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 5 encode the same protein (isoform 1).
      Source sequence(s)
      AC153607, AC156283, BC076615, D83033
      Consensus CDS
      CCDS20288.1
      UniProtKB/Swiss-Prot
      Q61464
      UniProtKB/TrEMBL
      A0A0N4SV80
      Related
      ENSMUSP00000144989.1, OTTMUSP00000073892, ENSMUST00000204751.2, OTTMUST00000141349
      Conserved Domains (8) summary
      smart00451
      Location:18751907
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:10061079
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:902976
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      TIGR01649
      Location:9031203
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      pfam05110
      Location:549674
      AF-4; AF-4 proto-oncoprotein
      cl17169
      Location:676751
      RRM_SF; RNA recognition motif (RRM) superfamily
      cl26511
      Location:740900
      Neuromodulin_N; Gap junction protein N-terminal region
      cl26950
      Location:10941437
      LsmAD; LsmAD domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      83867100..83986871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321434.1XP_017176923.1  zinc finger protein 638 isoform X8

      UniProtKB/TrEMBL
      E9QML5
      Conserved Domains (6) summary
      smart00451
      Location:19091941
      ZnF_U1; U1-like zinc finger
      COG5180
      Location:10941437
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      cd12436
      Location:10061079
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:902976
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      TIGR01649
      Location:9031203
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      cl17169
      Location:676751
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. XM_006505704.3XP_006505767.1  zinc finger protein 638 isoform X1

      Conserved Domains (5) summary
      smart00451
      Location:20052037
      ZnF_U1; U1-like zinc finger
      COG5180
      Location:11901533
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      cd12436
      Location:11021175
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:9981072
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      cl17169
      Location:772847
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. XM_006505706.3XP_006505769.1  zinc finger protein 638 isoform X3

      Conserved Domains (5) summary
      smart00451
      Location:19712003
      ZnF_U1; U1-like zinc finger
      COG5180
      Location:11901533
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      cd12436
      Location:11021175
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:9981072
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      cl17169
      Location:772847
      RRM_SF; RNA recognition motif (RRM) superfamily
    4. XM_006505711.3XP_006505774.1  zinc finger protein 638 isoform X12

      Related
      ENSMUSP00000145124.1, OTTMUSP00000073995, ENSMUST00000203324.2, OTTMUST00000141671
      Conserved Domains (4) summary
      smart00451
      Location:13181350
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:11021175
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:9981072
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      cl17169
      Location:772847
      RRM_SF; RNA recognition motif (RRM) superfamily
    5. XM_006505712.3XP_006505775.1  zinc finger protein 638 isoform X14

      Related
      ENSMUSP00000144939.1, OTTMUSP00000073994, ENSMUST00000203891.2, OTTMUST00000141670
      Conserved Domains (4) summary
      smart00451
      Location:12841316
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:11021175
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:9981072
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      cl17169
      Location:772847
      RRM_SF; RNA recognition motif (RRM) superfamily
    6. XM_006505705.3XP_006505768.1  zinc finger protein 638 isoform X2

      Conserved Domains (5) summary
      smart00451
      Location:19822014
      ZnF_U1; U1-like zinc finger
      COG5180
      Location:11671510
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      cd12436
      Location:10791152
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:9751049
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      cl17169
      Location:772847
      RRM_SF; RNA recognition motif (RRM) superfamily
    7. XM_017321429.1XP_017176918.1  zinc finger protein 638 isoform X5

    8. XM_017321435.1XP_017176924.1  zinc finger protein 638 isoform X13

    9. XM_006505707.3XP_006505770.1  zinc finger protein 638 isoform X4

      Conserved Domains (5) summary
      smart00451
      Location:19541986
      ZnF_U1; U1-like zinc finger
      COG5180
      Location:11391482
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      cd12436
      Location:10511124
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:9471021
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      cl17169
      Location:772847
      RRM_SF; RNA recognition motif (RRM) superfamily
    10. XM_017321430.1XP_017176919.1  zinc finger protein 638 isoform X7

    11. XM_011241247.2XP_011239549.1  zinc finger protein 638 isoform X6

      Conserved Domains (5) summary
      smart00451
      Location:19311963
      ZnF_U1; U1-like zinc finger
      COG5180
      Location:11161459
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      cd12436
      Location:10281101
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:924998
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      cl17169
      Location:772847
      RRM_SF; RNA recognition motif (RRM) superfamily
    12. XM_017321437.1XP_017176926.1  zinc finger protein 638 isoform X16

    13. XM_006505709.3XP_006505772.1  zinc finger protein 638 isoform X8

      See identical proteins and their annotated locations for XP_006505772.1

      UniProtKB/TrEMBL
      E9QML5
      Conserved Domains (6) summary
      smart00451
      Location:19091941
      ZnF_U1; U1-like zinc finger
      COG5180
      Location:10941437
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      cd12436
      Location:10061079
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:902976
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      TIGR01649
      Location:9031203
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      cl17169
      Location:676751
      RRM_SF; RNA recognition motif (RRM) superfamily
    14. XM_006505708.3XP_006505771.1  zinc finger protein 638 isoform X8

      See identical proteins and their annotated locations for XP_006505771.1

      UniProtKB/TrEMBL
      E9QML5
      Related
      ENSMUSP00000032088.8, OTTMUSP00000073982, ENSMUST00000032088.13, OTTMUST00000141635
      Conserved Domains (6) summary
      smart00451
      Location:19091941
      ZnF_U1; U1-like zinc finger
      COG5180
      Location:10941437
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      cd12436
      Location:10061079
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:902976
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      TIGR01649
      Location:9031203
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      cl17169
      Location:676751
      RRM_SF; RNA recognition motif (RRM) superfamily
    15. XM_006505714.3XP_006505777.1  zinc finger protein 638 isoform X15

      Conserved Domains (5) summary
      smart00451
      Location:11911223
      ZnF_U1; U1-like zinc finger
      COG5180
      Location:376719
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      cd12436
      Location:288361
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      TIGR01649
      Location:185485
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      cl17169
      Location:184258
      RRM_SF; RNA recognition motif (RRM) superfamily
    16. XM_017321438.1XP_017176927.1  zinc finger protein 638 isoform X17

    17. XM_017321431.1XP_017176920.1  zinc finger protein 638 isoform X9

      UniProtKB/TrEMBL
      A0A0N4SV80
      Conserved Domains (8) summary
      smart00451
      Location:18751907
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:10061079
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:902976
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      TIGR01649
      Location:9031203
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      pfam05110
      Location:549674
      AF-4; AF-4 proto-oncoprotein
      cl17169
      Location:676751
      RRM_SF; RNA recognition motif (RRM) superfamily
      cl26511
      Location:740900
      Neuromodulin_N; Gap junction protein N-terminal region
      cl26950
      Location:10941437
      LsmAD; LsmAD domain
    18. XM_006505710.3XP_006505773.1  zinc finger protein 638 isoform X10

      Conserved Domains (7) summary
      smart00451
      Location:18581890
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:9551028
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:851925
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      TIGR01649
      Location:8521152
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      pfam05110
      Location:549674
      AF-4; AF-4 proto-oncoprotein
      cl17169
      Location:676751
      RRM_SF; RNA recognition motif (RRM) superfamily
      cl26950
      Location:10431386
      LsmAD; LsmAD domain
    19. XM_017321432.1XP_017176921.1  zinc finger protein 638 isoform X10

      Conserved Domains (7) summary
      smart00451
      Location:18581890
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:9551028
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:851925
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      TIGR01649
      Location:8521152
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      pfam05110
      Location:549674
      AF-4; AF-4 proto-oncoprotein
      cl17169
      Location:676751
      RRM_SF; RNA recognition motif (RRM) superfamily
      cl26950
      Location:10431386
      LsmAD; LsmAD domain
    20. XM_017321433.1XP_017176922.1  zinc finger protein 638 isoform X11

      Conserved Domains (7) summary
      smart00451
      Location:18241856
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:9551028
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:851925
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      TIGR01649
      Location:8521152
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      pfam05110
      Location:549674
      AF-4; AF-4 proto-oncoprotein
      cl17169
      Location:676751
      RRM_SF; RNA recognition motif (RRM) superfamily
      cl26950
      Location:10431386
      LsmAD; LsmAD domain

    RNA

    1. XR_001785106.1 RNA Sequence

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