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    Cyb5r4 cytochrome b5 reductase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171015, updated on 12-Aug-2018

    Summary

    Official Symbol
    Cyb5r4provided by RGD
    Official Full Name
    cytochrome b5 reductase 4provided by RGD
    Primary source
    RGD:621834
    See related
    Ensembl:ENSRNOG00000010024
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ncb5or; b5&b5R; b5+b5R; cb5/cb5R
    Expression
    Biased expression in Kidney (RPKM 180.1), Thymus (RPKM 149.1) and 9 other tissues See more
    Orthologs

    Genomic context

    See Cyb5r4 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (94693273..94757989)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (94201509..94266046)

    Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351757 Neighboring gene ripply transcriptional repressor 2 Neighboring gene similar to Selenoprotein H Neighboring gene uncharacterized LOC103690445 Neighboring gene melanocortin 2 receptor accessory protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NAD(P)H oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    NAD(P)H oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    NOT NAD(P)H oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    NADPH-hemoprotein reductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytochrome-b5 reductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
     
    cytochrome-b5 reductase activity, acting on NAD(P)H ISO
    Inferred from Sequence Orthology
    more info
     
    flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    NADP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell development IEA
    Inferred from Electronic Annotation
    more info
     
    cell development ISO
    Inferred from Sequence Orthology
    more info
     
    generation of precursor metabolites and energy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    generation of precursor metabolites and energy IEA
    Inferred from Electronic Annotation
    more info
     
    generation of precursor metabolites and energy ISO
    Inferred from Sequence Orthology
    more info
     
    glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
     
    response to antibiotic ISO
    Inferred from Sequence Orthology
    more info
     
    superoxide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    superoxide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    superoxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cytochrome b5 reductase 4
    Names
    N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein
    NADPH cytochrome B5 oxidoreductase
    flavohemoprotein b5+b5R
    flavohemoprotein b5/b5R
    NP_596918.3
    XP_006243534.1
    XP_017450917.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133427.3NP_596918.3  cytochrome b5 reductase 4

      See identical proteins and their annotated locations for NP_596918.3

      Status: VALIDATED

      Source sequence(s)
      AC117045, BC080240
      UniProtKB/Swiss-Prot
      Q68EJ0
      UniProtKB/TrEMBL
      A0A0G2JSK2
      Related
      ENSRNOP00000013909.4, ENSRNOT00000013908.5
      Conserved Domains (3) summary
      cd06183
      Location:277518
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      cd06490
      Location:169255
      p23_NCB5OR; p23_like domain found in NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR) and similar proteins. NCB5OR is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum). It appears to play a critical role in maintaining ...
      pfam00173
      Location:56128
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

      Range
      94693273..94757989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243472.3XP_006243534.1  cytochrome b5 reductase 4 isoform X1

      Conserved Domains (3) summary
      cd06183
      Location:267508
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      cd06490
      Location:159245
      p23_NCB5OR; p23_like domain found in NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR) and similar proteins. NCB5OR is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum). It appears to play a critical role in maintaining ...
      pfam00173
      Location:56128
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    2. XM_017595428.1XP_017450917.1  cytochrome b5 reductase 4 isoform X2

    Alternate Rn_Celera

    Genomic

    1. AC_000076.1 Alternate Rn_Celera

      Range
      87566998..87631697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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