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    Lama1 laminin, alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 16772, updated on 4-Jun-2019

    Summary

    Official Symbol
    Lama1provided by MGI
    Official Full Name
    laminin, alpha 1provided by MGI
    Primary source
    MGI:MGI:99892
    See related
    Ensembl:ENSMUSG00000032796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lama; AA408497
    Expression
    Biased expression in ovary adult (RPKM 19.3), placenta adult (RPKM 10.0) and 8 other tissues See more
    Orthologs

    Genomic context

    See Lama1 in Genome Data Viewer
    Location:
    17 E1.1; 17 38.8 cM
    Exon count:
    64
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (67697127..67822645)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (68046605..68171985)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36201 Neighboring gene leucine rich repeat containing 30 Neighboring gene Rho GTPase activating protein 28 Neighboring gene predicted gene, 36252

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    extracellular matrix structural constituent IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular matrix structural constituent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    glycosphingolipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    blood vessel morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    branching involved in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    camera-type eye development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epithelial tube branching involved in lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    morphogenesis of an epithelial sheet IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retinal blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    basement membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen-containing extracellular matrix HDA PubMed 
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space HDA PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    laminin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    laminin-1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    laminin-1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    laminin-3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    laminin subunit alpha-1
    Names
    S-LAM alpha
    S-laminin subunit alpha
    laminin A chain
    laminin-1 subunit alpha
    laminin-3 subunit alpha

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008480.2NP_032506.2  laminin subunit alpha-1 precursor

      See identical proteins and their annotated locations for NP_032506.2

      Status: VALIDATED

      Source sequence(s)
      AC154823, AK051116, CA535780, CN461817, CN535171, J04064
      Consensus CDS
      CCDS37681.1
      UniProtKB/Swiss-Prot
      P19137
      UniProtKB/TrEMBL
      F8VQ40
      Related
      ENSMUSP00000043957.7, ENSMUST00000035471.8
      Conserved Domains (10) summary
      smart00136
      Location:25275
      LamNT; Laminin N-terminal domain (domain VI)
      smart00180
      Location:9581002
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:15161553
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:29003053
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:909955
      Laminin_EGF; Laminin EGF domain
      pfam00054
      Location:27512880
      Laminin_G_1; Laminin G domain
      pfam06009
      Location:20182152
      Laminin_II; Laminin Domain II
      pfam00052
      Location:575714
      Laminin_B; Laminin B (Domain IV)
      pfam06008
      Location:15821837
      Laminin_I; Laminin Domain I
      cl25642
      Location:18272064
      DUF390; Protein of unknown function (DUF390)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      67697127..67822645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523718.3XP_006523781.1  laminin subunit alpha-1 isoform X2

      Conserved Domains (4) summary
      smart00136
      Location:25275
      LamNT; Laminin N-terminal domain (domain VI)
      cd00055
      Location:15161553
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00052
      Location:575703
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:909955
      Laminin_EGF; Laminin EGF domain
    2. XM_006523717.3XP_006523780.1  laminin subunit alpha-1 isoform X1

      Conserved Domains (10) summary
      smart00136
      Location:25275
      LamNT; Laminin N-terminal domain (domain VI)
      smart00180
      Location:9581002
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:15161553
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:23142470
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00052
      Location:575703
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:909955
      Laminin_EGF; Laminin EGF domain
      pfam00054
      Location:27512880
      Laminin_G_1; Laminin G domain
      pfam06008
      Location:15741837
      Laminin_I; Laminin Domain I
      pfam06009
      Location:20182152
      Laminin_II; Laminin Domain II
      cl12013
      Location:16141786
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
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