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    Krt13 keratin 13 [ Mus musculus (house mouse) ]

    Gene ID: 16663, updated on 5-Aug-2018

    Summary

    Official Symbol
    Krt13provided by MGI
    Official Full Name
    keratin 13provided by MGI
    Primary source
    MGI:MGI:101925
    See related
    Ensembl:ENSMUSG00000044041 Vega:OTTMUSG00000002539
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K13; CK13; Krt1-13; Krt-1.13
    Summary
    The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in lung adult (RPKM 380.7) and stomach adult (RPKM 364.4) See more
    Orthologs

    Genomic context

    See Krt13 in Genome Data Viewer
    Location:
    11 D; 11 63.41 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (100117327..100121566, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (99978910..99982809, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene keratin 35 Neighboring gene keratin 36 Neighboring gene keratin 15 Neighboring gene keratin 19

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     
    intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    keratin filament ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    keratin, type I cytoskeletal 13
    Names
    47 kDa cytokeratin
    CK-13
    cytokeratin 13
    keratin complex 1, acidic, gene 13

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313949.1NP_001300878.1  keratin, type I cytoskeletal 13 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate first exon in place of that of variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK132640, BQ561384, EH100895
      UniProtKB/Swiss-Prot
      P08730
      Conserved Domains (1) summary
      pfam00038
      Location:1189
      Filament; Intermediate filament protein
    2. NM_010662.2NP_034792.1  keratin, type I cytoskeletal 13 isoform 1

      See identical proteins and their annotated locations for NP_034792.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK132640, EH100895
      Consensus CDS
      CCDS25409.1
      UniProtKB/Swiss-Prot
      P08730
      Related
      ENSMUSP00000007275.2, OTTMUSP00000002390, ENSMUST00000007275.2, OTTMUST00000004964
      Conserved Domains (1) summary
      pfam00038
      Location:95407
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      100117327..100121566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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