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    Kif21a kinesin family member 21A [ Mus musculus (house mouse) ]

    Gene ID: 16564, updated on 9-Sep-2018

    Summary

    Official Symbol
    Kif21aprovided by MGI
    Official Full Name
    kinesin family member 21Aprovided by MGI
    Primary source
    MGI:MGI:109188
    See related
    Ensembl:ENSMUSG00000022629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Broad expression in CNS E11.5 (RPKM 13.0), CNS E14 (RPKM 12.8) and 21 other tissues See more
    Orthologs

    Genomic context

    See Kif21a in Genome Data Viewer
    Location:
    15 E3; 15 45.86 cM
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (90933275..91050208, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (90763707..90880379, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene sialophorin, pseudogene Neighboring gene predicted gene, 36618 Neighboring gene predicted gene, 36710 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • mKIAA1708

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kinesin-like protein KIF21A
    Names
    N-5 kinesin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109040.2NP_001102510.1  kinesin-like protein KIF21A isoform 1

      See identical proteins and their annotated locations for NP_001102510.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC136003, AK019525, AK049303, AK052821, AK053373, AK147436, AK163536, BC062896, BY714299
      Consensus CDS
      CCDS49708.1
      UniProtKB/Swiss-Prot
      Q9QXL2
      UniProtKB/TrEMBL
      Q3TQJ5, Q3UHE7, Q3V416
      Related
      ENSMUSP00000085985.5, ENSMUST00000088614.12
      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:13431650
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:670806
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:13371650
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:664801
      FliJ; Flagellar FliJ protein
      sd00039
      Location:13881447
      7WD40; WD40 repeat [structural motif]
    2. NM_001109041.2NP_001102511.1  kinesin-like protein KIF21A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC136003, AK019525, AK052821, AK053373, AK147436, BC060698, BY714299
      Consensus CDS
      CCDS49707.1
      UniProtKB/Swiss-Prot
      Q9QXL2
      UniProtKB/TrEMBL
      F8WGN6, Q3UHE7, Q3V416
      Related
      ENSMUSP00000066911.8, ENSMUST00000067205.15
      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:12991606
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:657793
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:12931606
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:651788
      FliJ; Flagellar FliJ protein
      sd00039
      Location:13441403
      7WD40; WD40 repeat [structural motif]
    3. NM_001109042.2NP_001102512.1  kinesin-like protein KIF21A isoform 4

      See identical proteins and their annotated locations for NP_001102512.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks four alternate exons in the central coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1.
      Source sequence(s)
      AC136003, AK019525, AK052821, AK053373, BC060698, BY714299
      Consensus CDS
      CCDS49706.1
      UniProtKB/Swiss-Prot
      Q9QXL2
      UniProtKB/TrEMBL
      Q3V416
      Related
      ENSMUSP00000104910.2, ENSMUST00000109287.3
      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:12381545
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:657793
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:12321545
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:651788
      FliJ; Flagellar FliJ protein
      sd00039
      Location:12831342
      7WD40; WD40 repeat [structural motif]
    4. NM_001358050.1NP_001344979.1  kinesin-like protein KIF21A isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks alternate exons in the central coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter, compared to isoform 1.
      Source sequence(s)
      AC113102, AC136003
      Conserved Domains (5) summary
      cd00200
      Location:12681581
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      sd00039
      Location:13191378
      7WD40; WD40 repeat [structural motif]
      cl25732
      Location:633827
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26252
      Location:6801102
      AAA_13; AAA domain
    5. NM_016705.4NP_057914.2  kinesin-like protein KIF21A isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks four alternate exons in the central coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AC136003, AK019525, AK052821, AK053373, AK147436, BC060698, BY714299
      Consensus CDS
      CCDS37179.1
      UniProtKB/Swiss-Prot
      Q9QXL2
      UniProtKB/TrEMBL
      Q3UHE7, Q3V416
      Related
      ENSMUSP00000104911.2, ENSMUST00000109288.8
      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:12441551
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:657793
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:12381551
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:651788
      FliJ; Flagellar FliJ protein
      sd00039
      Location:12891348
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      90933275..91050208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316478.1XP_017171967.1  kinesin-like protein KIF21A isoform X38

    2. XM_017316445.1XP_017171934.1  kinesin-like protein KIF21A isoform X5

    3. XM_006520495.3XP_006520558.1  kinesin-like protein KIF21A isoform X9

      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:13351642
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:657793
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:13291642
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:651788
      FliJ; Flagellar FliJ protein
      sd00039
      Location:13801439
      7WD40; WD40 repeat [structural motif]
    4. XM_017316467.1XP_017171956.1  kinesin-like protein KIF21A isoform X28

      Conserved Domains (5) summary
      cd00200
      Location:12681581
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      sd00039
      Location:13191378
      7WD40; WD40 repeat [structural motif]
      cl25732
      Location:633827
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26252
      Location:6801102
      AAA_13; AAA domain
    5. XM_017316476.1XP_017171965.1  kinesin-like protein KIF21A isoform X36

    6. XM_017316466.1XP_017171955.1  kinesin-like protein KIF21A isoform X27

    7. XM_017316462.1XP_017171951.1  kinesin-like protein KIF21A isoform X23

    8. XM_017316452.1XP_017171941.1  kinesin-like protein KIF21A isoform X13

    9. XM_017316479.1XP_017171968.1  kinesin-like protein KIF21A isoform X39

    10. XM_017316474.1XP_017171963.1  kinesin-like protein KIF21A isoform X34

    11. XM_017316473.1XP_017171962.1  kinesin-like protein KIF21A isoform X33

    12. XM_017316472.1XP_017171961.1  kinesin-like protein KIF21A isoform X32

    13. XM_017316461.1XP_017171950.1  kinesin-like protein KIF21A isoform X22

    14. XM_017316456.1XP_017171945.1  kinesin-like protein KIF21A isoform X17

    15. XM_017316463.1XP_017171952.1  kinesin-like protein KIF21A isoform X24

    16. XM_017316459.1XP_017171948.1  kinesin-like protein KIF21A isoform X20

    17. XM_017316449.1XP_017171938.1  kinesin-like protein KIF21A isoform X10

    18. XM_017316447.1XP_017171936.1  kinesin-like protein KIF21A isoform X7

    19. XM_017316446.1XP_017171935.1  kinesin-like protein KIF21A isoform X6

    20. XM_017316477.1XP_017171966.1  kinesin-like protein KIF21A isoform X37

    21. XM_017316471.1XP_017171960.1  kinesin-like protein KIF21A isoform X31

    22. XM_017316470.1XP_017171959.1  kinesin-like protein KIF21A isoform X30

    23. XM_017316458.1XP_017171947.1  kinesin-like protein KIF21A isoform X19

    24. XM_017316457.1XP_017171946.1  kinesin-like protein KIF21A isoform X18

    25. XM_017316444.1XP_017171933.1  kinesin-like protein KIF21A isoform X4

    26. XM_017316475.1XP_017171964.1  kinesin-like protein KIF21A isoform X35

    27. XM_017316468.1XP_017171957.1  kinesin-like protein KIF21A isoform X29

    28. XM_017316465.1XP_017171954.1  kinesin-like protein KIF21A isoform X26

    29. XM_017316464.1XP_017171953.1  kinesin-like protein KIF21A isoform X25

    30. XM_017316451.1XP_017171940.1  kinesin-like protein KIF21A isoform X12

    31. XM_017316450.1XP_017171939.1  kinesin-like protein KIF21A isoform X11

    32. XM_017316460.1XP_017171949.1  kinesin-like protein KIF21A isoform X21

    33. XM_017316455.1XP_017171944.1  kinesin-like protein KIF21A isoform X16

    34. XM_017316454.1XP_017171943.1  kinesin-like protein KIF21A isoform X15

    35. XM_017316453.1XP_017171942.1  kinesin-like protein KIF21A isoform X14

    36. XM_017316448.1XP_017171937.1  kinesin-like protein KIF21A isoform X8

    37. XM_017316442.1XP_017171931.1  kinesin-like protein KIF21A isoform X2

    38. XM_017316441.1XP_017171930.1  kinesin-like protein KIF21A isoform X1

    39. XM_017316443.1XP_017171932.1  kinesin-like protein KIF21A isoform X3

    RNA

    1. XR_001781495.1 RNA Sequence

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