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    Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 [ Mus musculus (house mouse) ]

    Gene ID: 15485, updated on 16-Jul-2019

    Summary

    Official Symbol
    Hsd17b1provided by MGI
    Official Full Name
    hydroxysteroid (17-beta) dehydrogenase 1provided by MGI
    Primary source
    MGI:MGI:105077
    See related
    Ensembl:ENSMUSG00000019301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E2DH; 17HSDB1; Hsd17ba; 17beta-HSD
    Expression
    Restricted expression toward ovary adult (RPKM 78.1) See more
    Orthologs

    Genomic context

    See Hsd17b1 in Genome Data Viewer
    Location:
    11 D; 11 64.17 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (101077968..101081188)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (100939725..100941819)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit A1 Neighboring gene microRNA 6928 Neighboring gene alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) Neighboring gene Coenzyme A synthase Neighboring gene MAX-like protein X Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NADP+ binding ISO
    Inferred from Sequence Orthology
    more info
     
    estradiol 17-beta-dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    estradiol binding ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    steroid binding ISO
    Inferred from Sequence Orthology
    more info
     
    testosterone dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    estrogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    testosterone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    estradiol 17-beta-dehydrogenase 1
    Names
    17-beta-HSD 1
    17-beta-hydroxysteroid dehydrogenase type 1
    NP_034605.1
    XP_006532360.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010475.2NP_034605.1  estradiol 17-beta-dehydrogenase 1

      See identical proteins and their annotated locations for NP_034605.1

      Status: VALIDATED

      Source sequence(s)
      BE691221, X89627
      Consensus CDS
      CCDS25445.1
      UniProtKB/Swiss-Prot
      P51656
      UniProtKB/TrEMBL
      Q790P4
      Related
      ENSMUSP00000019445.5, ENSMUST00000019445.5
      Conserved Domains (2) summary
      pfam00106
      Location:5192
      adh_short; short chain dehydrogenase
      cl21454
      Location:4260
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      101077968..101081188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532297.2XP_006532360.1  estradiol 17-beta-dehydrogenase 1 isoform X1

      Conserved Domains (2) summary
      PRK08263
      Location:1204
      PRK08263; short chain dehydrogenase; Provisional
      cl21454
      Location:4200
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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