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    Hira histone cell cycle regulator [ Mus musculus (house mouse) ]

    Gene ID: 15260, updated on 9-Jun-2019

    Summary

    Official Symbol
    Hiraprovided by MGI
    Official Full Name
    histone cell cycle regulatorprovided by MGI
    Primary source
    MGI:MGI:99430
    See related
    Ensembl:ENSMUSG00000022702
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N28177; Tuple1; Gm15797; AA138857; D16Ertd95e
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 13.7), CNS E14 (RPKM 13.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Hira in Genome Data Viewer
    Location:
    16 A3; 16 11.69 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (18876750..18970309)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (18876843..18970402)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2510002D24 gene Neighboring gene mitochondrial ribosomal protein L40 Neighboring gene U2 small nuclear ribonucleoprotein B pseudogene Neighboring gene ubiquitin-conjugating enzyme E2 pseudogene Neighboring gene immunoglobulin lambda chain complex

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA replication-independent nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA replication-independent nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin silencing at centromere IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    osteoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of chromatin silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    HIR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein HIRA
    Names
    TUP1-like enhancer of split gene 1
    TUP1-like enhancer of split protein 1
    histone cell cycle regulation defective homolog A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010435.2NP_034565.2  protein HIRA

      See identical proteins and their annotated locations for NP_034565.2

      Status: VALIDATED

      Source sequence(s)
      AK168963, BC060181, CA323899
      Consensus CDS
      CCDS28031.1
      UniProtKB/Swiss-Prot
      Q61666
      Related
      ENSMUSP00000004222.7, ENSMUST00000004222.13
      Conserved Domains (5) summary
      COG2319
      Location:7372
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:7352
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam07569
      Location:761952
      Hira; TUP1-like enhancer of split
      pfam09453
      Location:448469
      HIRA_B; HIRA B motif
      sd00039
      Location:1661
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      18876750..18970309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521801.3XP_006521864.1  protein HIRA isoform X3

      Conserved Domains (5) summary
      COG2319
      Location:1279
      WD40; WD40 repeat [General function prediction only]
      pfam07569
      Location:679870
      Hira; TUP1-like enhancer of split
      pfam09453
      Location:366387
      HIRA_B; HIRA B motif
      sd00039
      Location:5390
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:2270
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_006521799.3XP_006521862.1  protein HIRA isoform X2

      See identical proteins and their annotated locations for XP_006521862.1

      Conserved Domains (5) summary
      COG2319
      Location:20317
      WD40; WD40 repeat [General function prediction only]
      pfam07569
      Location:717908
      Hira; TUP1-like enhancer of split
      pfam09453
      Location:404425
      HIRA_B; HIRA B motif
      sd00039
      Location:3185
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:25308
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_006521800.2XP_006521863.1  protein HIRA isoform X2

      See identical proteins and their annotated locations for XP_006521863.1

      Conserved Domains (5) summary
      COG2319
      Location:20317
      WD40; WD40 repeat [General function prediction only]
      pfam07569
      Location:717908
      Hira; TUP1-like enhancer of split
      pfam09453
      Location:404425
      HIRA_B; HIRA B motif
      sd00039
      Location:3185
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:25308
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_006521798.3XP_006521861.1  protein HIRA isoform X1

      Conserved Domains (5) summary
      COG2319
      Location:29387
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:29367
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam07569
      Location:776967
      Hira; TUP1-like enhancer of split
      pfam09453
      Location:463484
      HIRA_B; HIRA B motif
      sd00039
      Location:3176
      7WD40; WD40 repeat [structural motif]
    5. XM_006521802.3XP_006521865.1  protein HIRA isoform X4

      Conserved Domains (2) summary
      pfam07569
      Location:420611
      Hira; TUP1-like enhancer of split
      pfam09453
      Location:107128
      HIRA_B; HIRA B motif

    RNA

    1. XR_384527.3 RNA Sequence

    Reference GRCm38.p4 129S1/SvImJ

    Genomic

    1. NT_187008.1 Reference GRCm38.p4 129S1/SvImJ

      Range
      180430..250224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 129S6/SvEvTac

    Genomic

    1. NT_187014.1 Reference GRCm38.p4 129S6/SvEvTac

      Range
      12869..88388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001005228.1: Suppressed sequence

      Description
      NM_001005228.1: This RefSeq was temporarily suppressed because currently there are not sufficient data to support this transcript.
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