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    Gpc3 glypican 3 [ Mus musculus (house mouse) ]

    Gene ID: 14734, updated on 9-Sep-2018

    Summary

    Official Symbol
    Gpc3provided by MGI
    Official Full Name
    glypican 3provided by MGI
    Primary source
    MGI:MGI:104903
    See related
    Ensembl:ENSMUSG00000055653 Vega:OTTMUSG00000017333
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OCI-5
    Expression
    Biased expression in limb E14.5 (RPKM 231.9), liver E18 (RPKM 187.4) and 13 other tissues See more
    Orthologs

    Genomic context

    See Gpc3 in Genome Data Viewer
    Location:
    X; X A5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (52272426..52613974, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (49625603..49967151, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700080O16 gene Neighboring gene predicted gene, 35790 Neighboring gene glypican 4 Neighboring gene microRNA 6384 Neighboring gene microRNA 717 Neighboring gene RIKEN cDNA A630012P03 gene Neighboring gene microRNA 92-2 Neighboring gene microRNA 363

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-dipeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anterior/posterior axis specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in ureteric bud morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell proliferation involved in kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation involved in metanephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic hindlimb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesenchymal cell proliferation involved in ureteric bud development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesonephric duct morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of Wnt signaling pathway, planar cell polarity pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of Wnt signaling pathway, planar cell polarity pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of glucose import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of non-canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    anchored component of plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anchored component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016697.3NP_057906.2  glypican-3 precursor

      See identical proteins and their annotated locations for NP_057906.2

      Status: VALIDATED

      Source sequence(s)
      AK146702, AK168402, CJ166243, CJ321827
      Consensus CDS
      CCDS30125.1
      UniProtKB/Swiss-Prot
      Q8CFZ4
      UniProtKB/TrEMBL
      Q3TWB2
      Related
      ENSMUSP00000064131.7, OTTMUSP00000018969, ENSMUST00000069360.13, OTTMUST00000042115
      Conserved Domains (1) summary
      pfam01153
      Location:14576
      Glypican; Glypican

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      52272426..52613974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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