Format

Send to:

Choose Destination
    • Showing Current items.

    Mat1a methionine adenosyltransferase I, alpha [ Mus musculus (house mouse) ]

    Gene ID: 11720, updated on 23-May-2018

    Summary

    Official Symbol
    Mat1aprovided by MGI
    Official Full Name
    methionine adenosyltransferase I, alphaprovided by MGI
    Primary source
    MGI:MGI:88017
    See related
    Ensembl:ENSMUSG00000037798
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ams; MAT; SAMS; MATA1; SAMS1; AdoMet; AI046368
    Summary
    This gene encodes a member of the AdoMet synthase family. Methionine adenosyltransferase is a product of this gene (the alpha form) and the beta form and catalyzes the formation of S-adenosylmethionine from methionine and ATP.[provided by RefSeq, Jan 2013]
    Expression
    Restricted expression toward liver adult (RPKM 598.5) See more
    Orthologs

    Genomic context

    See Mat1a in Genome Data Viewer
    Location:
    14; 14 B
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (41105008..41124428)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (41918670..41937701)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 213, member A Neighboring gene DPY30 domain containing 2 Neighboring gene DPY30 domain containing 1 Neighboring gene surfactant associated protein A1 Neighboring gene pleckstrin homology domain containing, family F (with FYVE domain) member 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    methionine adenosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    methionine adenosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    methionine adenosyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    S-adenosylmethionine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    methionine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    S-adenosylmethionine synthase isoform type-1; S-adenosylmethionine synthase
    Names
    adoMet synthetase 1
    NP_598414.1
    XP_006518513.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133653.3NP_598414.1  S-adenosylmethionine synthase isoform type-1

      See identical proteins and their annotated locations for NP_598414.1

      Status: REVIEWED

      Source sequence(s)
      AC124400, AC154597, AK153832, BB807316, BB871001
      Consensus CDS
      CCDS26959.1
      UniProtKB/Swiss-Prot
      Q91X83
      Related
      ENSMUSP00000153488.1, ENSMUST00000225720.1
      Conserved Domains (4) summary
      PTZ00104
      Location:17394
      PTZ00104; S-adenosylmethionine synthase; Provisional
      pfam00438
      Location:19115
      S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
      pfam02772
      Location:130251
      S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
      pfam02773
      Location:253389
      S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      41105008..41124428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518450.2XP_006518513.1  S-adenosylmethionine synthase isoform X1

      See identical proteins and their annotated locations for XP_006518513.1

      UniProtKB/Swiss-Prot
      Q91X83
      Conserved Domains (4) summary
      PTZ00104
      Location:17394
      PTZ00104; S-adenosylmethionine synthase; Provisional
      pfam00438
      Location:19115
      S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
      pfam02772
      Location:130251
      S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
      pfam02773
      Location:253389
      S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain
    Support Center