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    Eif2b4 eukaryotic translation initiation factor 2B subunit delta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117019, updated on 21-Jul-2018

    Summary

    Official Symbol
    Eif2b4provided by RGD
    Official Full Name
    eukaryotic translation initiation factor 2B subunit deltaprovided by RGD
    Primary source
    RGD:620208
    See related
    Ensembl:ENSRNOG00000005301
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Eif2b
    Summary
    mediates the exchange of GDP bound to translation initiation factor eIF2 for GTP [RGD, Feb 2006]
    Expression
    Biased expression in Muscle (RPKM 207.1), Heart (RPKM 166.2) and 9 other tissues See more
    Orthologs

    Genomic context

    See Eif2b4 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (26546917..26552474)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (36364317..36369311)

    Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene zinc finger protein 513 Neighboring gene sorting nexin 17 Neighboring gene general transcription factor IIIC subunit 2 Neighboring gene mitochondrial inner membrane protein MPV17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    hippocampus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    myelination ISO
    Inferred from Sequence Orthology
    more info
     
    myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oligodendrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    oligodendrocyte development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    ovarian follicle development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to glucose IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to peptide hormone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    translational initiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    eukaryotic translation initiation factor 2B complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    eukaryotic translation initiation factor 2B complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    eukaryotic translation initiation factor 2B complex ISO
    Inferred from Sequence Orthology
    more info
     
    eukaryotic translation initiation factor 2B complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    eukaryotic translation initiation factor 2B complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    translation initiation factor eIF-2B subunit delta
    Names
    eIF-2B GDP-GTP exchange factor subunit delta
    eukaryotic translation initiation factor 2B subunit 4
    eukaryotic translation initiation factor 2B, subunit 4 delta

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053950.1NP_446402.1  translation initiation factor eIF-2B subunit delta

      See identical proteins and their annotated locations for NP_446402.1

      Status: PROVISIONAL

      Source sequence(s)
      Z48225
      UniProtKB/Swiss-Prot
      Q63186
      Related
      ENSRNOP00000007763.4, ENSRNOT00000007763.5
      Conserved Domains (2) summary
      COG1184
      Location:220518
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:220510
      IF-2B; Initiation factor 2 subunit family

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

      Range
      26546917..26552474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000074.1 Alternate Rn_Celera

      Range
      24674570..24680134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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