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    Rgs14 regulator of G-protein signaling 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114705, updated on 2-Oct-2018

    Summary

    Official Symbol
    Rgs14provided by RGD
    Official Full Name
    regulator of G-protein signaling 14provided by RGD
    Primary source
    RGD:620003
    See related
    Ensembl:ENSRNOG00000015616
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    binds Galpha(i1)GDP and acts as a GTPase activator by maintaining G-protein subunit dissociation; regulates G-protein mediated signaling [RGD, Feb 2006]
    Expression
    Biased expression in Thymus (RPKM 184.2), Spleen (RPKM 69.0) and 3 other tissues See more
    Orthologs

    Genomic context

    See Rgs14 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9777925..9792007, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (11887270..11901352, complement)

    Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene solute carrier family 34 member 1 Neighboring gene profilin 3 Neighboring gene lectin, mannose-binding 2 Neighboring gene uncharacterized LOC102550438 Neighboring gene Max dimerization protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...

    General gene information

    Markers

    Homology

    Clone Names

    • MGC108631

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    G-protein alpha-subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    GDP-dissociation inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GDP-dissociation inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activating protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activating protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor signaling complex scaffold activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell division ISO
    Inferred from Sequence Orthology
    more info
     
    cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    learning ISO
    Inferred from Sequence Orthology
    more info
     
    learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    long-term memory ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleocytoplasmic transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of DNA-templated transcription in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of DNA-templated transcription in response to stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    zygote asymmetric cell division ISO
    Inferred from Sequence Orthology
    more info
     
    zygote asymmetric cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    PML body IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    spindle ISO
    Inferred from Sequence Orthology
    more info
     
    spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    regulator of G-protein signaling 14

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053764.1NP_446216.1  regulator of G-protein signaling 14

      See identical proteins and their annotated locations for NP_446216.1

      Status: PROVISIONAL

      Source sequence(s)
      U92279
      UniProtKB/Swiss-Prot
      O08773
      Related
      ENSRNOP00000021596.1, ENSRNOT00000021596.2
      Conserved Domains (4) summary
      cd01817
      Location:301374
      RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
      cd08743
      Location:58186
      RGS_RGS14; Regulator of G protein signaling (RGS) domain found in the RGS14 protein
      smart00390
      Location:497519
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cl00155
      Location:382443
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

      Range
      9777925..9792007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000085.1 Alternate Rn_Celera

      Range
      9327534..9341623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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