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    LYPLA2 lysophospholipase 2 [ Homo sapiens (human) ]

    Gene ID: 11313, updated on 27-Oct-2018

    Summary

    Official Symbol
    LYPLA2provided by HGNC
    Official Full Name
    lysophospholipase 2provided by HGNC
    Primary source
    HGNC:HGNC:6738
    See related
    Ensembl:ENSG00000011009 MIM:616143; Vega:OTTHUMG00000002961
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APT2; APT-2; DJ886K2.4
    Summary
    Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in placenta (RPKM 17.1), duodenum (RPKM 15.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See LYPLA2 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (23790789..23795539)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24117275..24122029)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene elongin A Neighboring gene ELOA antisense RNA 1 Neighboring gene PITH domain containing 1 Neighboring gene uncharacterized LOC105376860 Neighboring gene UDP-galactose-4-epimerase Neighboring gene 3-hydroxy-3-methylglutaryl-CoA lyase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Glycerophospholipid metabolism, organism-specific biosystem (from KEGG)
      Glycerophospholipid metabolism, organism-specific biosystem
      Glycerophospholipid metabolism
    • Glycerophospholipid metabolism, conserved biosystem (from KEGG)
      Glycerophospholipid metabolism, conserved biosystem
      Glycerophospholipid metabolism
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cadherin binding HDA PubMed 
    carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    palmitoyl-(protein) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    palmitoyl-(protein) hydrolase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    axon guidance TAS
    Traceable Author Statement
    more info
     
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    protein depalmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein depalmitoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi stack IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 

    General protein information

    Preferred Names
    acyl-protein thioesterase 2
    Names
    LPL-II
    lysoPLA II
    lysophospholipase II
    testicular tissue protein Li 3
    NP_009191.1
    XP_005245785.1
    XP_016855654.1
    XP_024308564.1
    XP_024308565.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007260.2NP_009191.1  acyl-protein thioesterase 2

      Status: REVIEWED

      Source sequence(s)
      AF098668
      Consensus CDS
      CCDS241.1
      UniProtKB/Swiss-Prot
      O95372
      UniProtKB/TrEMBL
      A0A140VJC9
      Related
      ENSP00000363638.3, OTTHUMP00000002999, ENST00000374514.7, OTTHUMT00000008245
      Conserved Domains (1) summary
      pfam02230
      Location:14228
      Abhydrolase_2; Phospholipase/Carboxylesterase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      23790789..23795539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024452796.1XP_024308564.1  acyl-protein thioesterase 2 isoform X1

      Conserved Domains (1) summary
      pfam02230
      Location:26284
      Abhydrolase_2; Phospholipase/Carboxylesterase
    2. XM_024452797.1XP_024308565.1  acyl-protein thioesterase 2 isoform X2

      Conserved Domains (1) summary
      pfam02230
      Location:14272
      Abhydrolase_2; Phospholipase/Carboxylesterase
    3. XM_017000165.1XP_016855654.1  acyl-protein thioesterase 2 isoform X4

    4. XM_005245728.5XP_005245785.1  acyl-protein thioesterase 2 isoform X3

      Conserved Domains (1) summary
      pfam02230
      Location:26240
      Abhydrolase_2; Phospholipase/Carboxylesterase
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