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    Rnf20 ring finger protein 20 [ Mus musculus (house mouse) ]

    Gene ID: 109331, updated on 5-Aug-2018

    Summary

    Official Symbol
    Rnf20provided by MGI
    Official Full Name
    ring finger protein 20provided by MGI
    Primary source
    MGI:MGI:1925927
    See related
    Ensembl:ENSMUSG00000028309 Vega:OTTMUSG00000006927
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C79397; AW540162; mKIAA4116; 4833430L21Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 22.3), CNS E14 (RPKM 15.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rnf20 in Genome Data Viewer
    Location:
    4; 4 B1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (49632006..49656887)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (49644932..49669758)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33159 Neighboring gene predicted gene, 45952 Neighboring gene glutamate receptor ionotropic, NMDA3A Neighboring gene protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) Neighboring gene predicted gene, 42286

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4116

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    histone H2B ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    histone monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    histone ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mRNA polyadenylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of histone H2B ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of histone methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    HULC complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase BRE1A
    Names
    BRE1-A
    RING-type E3 ubiquitin transferase BRE1A
    NP_001156735.1
    NP_892044.1
    XP_006537616.1
    XP_011248208.1
    XP_017175405.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163263.1NP_001156735.1  E3 ubiquitin-protein ligase BRE1A isoform 1

      See identical proteins and their annotated locations for NP_001156735.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK051278, AK139883, BF730643, BQ442966, CJ052397, CN531555, DV660388
      Consensus CDS
      CCDS18178.1
      UniProtKB/Swiss-Prot
      Q5DTM8
      Related
      ENSMUSP00000128546.1, ENSMUST00000167496.7
      Conserved Domains (1) summary
      cd00162
      Location:919962
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. NM_001356401.1NP_001343330.1  E3 ubiquitin-protein ligase BRE1A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK053783, AK139883, AL732521, BF730643, BQ442966, CN531555, DV660388
      Conserved Domains (2) summary
      cd16704
      Location:673718
      RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins
      cl26511
      Location:75689
      Neuromodulin_N; Gap junction protein N-terminal region
    3. NM_182999.2NP_892044.1  E3 ubiquitin-protein ligase BRE1A isoform 1

      See identical proteins and their annotated locations for NP_892044.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK053783, AK139883, BF730643, BQ442966, CJ052397, CN531555, DV660388
      Consensus CDS
      CCDS18178.1
      UniProtKB/Swiss-Prot
      Q5DTM8
      Related
      ENSMUSP00000029989.4, OTTMUSP00000007359, ENSMUST00000029989.10, OTTMUST00000016027
      Conserved Domains (1) summary
      cd00162
      Location:919962
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      49632006..49656887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537553.3XP_006537616.1  E3 ubiquitin-protein ligase BRE1A isoform X1

      See identical proteins and their annotated locations for XP_006537616.1

      UniProtKB/Swiss-Prot
      Q5DTM8
      Conserved Domains (1) summary
      cd00162
      Location:919962
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. XM_011249906.2XP_011248208.1  E3 ubiquitin-protein ligase BRE1A isoform X1

      See identical proteins and their annotated locations for XP_011248208.1

      UniProtKB/Swiss-Prot
      Q5DTM8
      Conserved Domains (1) summary
      cd00162
      Location:919962
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    3. XM_017319916.1XP_017175405.1  E3 ubiquitin-protein ligase BRE1A isoform X2

      Conserved Domains (2) summary
      cd16704
      Location:673718
      RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins
      cl26511
      Location:75689
      Neuromodulin_N; Gap junction protein N-terminal region
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