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    ZNF211 zinc finger protein 211 [ Homo sapiens (human) ]

    Gene ID: 10520, updated on 7-Oct-2018

    Summary

    Official Symbol
    ZNF211provided by HGNC
    Official Full Name
    zinc finger protein 211provided by HGNC
    Primary source
    HGNC:HGNC:13003
    See related
    Ensembl:ENSG00000121417 MIM:601856; Vega:OTTHUMG00000168012
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF-25; C2H2-25; CH2H2-25
    Summary
    This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. This protein may play a role in developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
    Expression
    Ubiquitous expression in bone marrow (RPKM 5.3), thyroid (RPKM 4.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See ZNF211 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (57633167..57644046)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58144535..58155409)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 530 Neighboring gene zinc finger protein 134 Neighboring gene zinc finger and SCAN domain containing 4 Neighboring gene tumor protein p63 regulated 1 like pseudogene 1 Neighboring gene zinc finger protein 551

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC131841

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 211
    Names
    zinc finger protein C2H2-25

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034028.1 RefSeqGene

      Range
      5001..15880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001265597.2NP_001252526.1  zinc finger protein 211 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is longer than isoform 1.
      Source sequence(s)
      AC003682, AK294869, AL559417, BQ678885, DA961612, DR002950
      Consensus CDS
      CCDS58686.1
      UniProtKB/Swiss-Prot
      Q13398
      Related
      ENSP00000299871.5, OTTHUMP00000237580, ENST00000299871.9, OTTHUMT00000397506
      Conserved Domains (6) summary
      smart00349
      Location:46106
      KRAB; krueppel associated box
      COG5048
      Location:244615
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:520540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:518540
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:4685
      KRAB; KRAB box
      pfam13465
      Location:420445
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001265598.2NP_001252527.1  zinc finger protein 211 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon and includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is longer than isoform 1.
      Source sequence(s)
      AC003682, AK294869, BQ678885, DA961612, DR002950
      Consensus CDS
      CCDS74468.1
      UniProtKB/Swiss-Prot
      Q13398
      UniProtKB/TrEMBL
      A0A0A0MTK1
      Related
      ENSP00000442601.2, ENST00000541801.5
      Conserved Domains (6) summary
      smart00349
      Location:3393
      KRAB; krueppel associated box
      COG5048
      Location:231602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:505527
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:3372
      KRAB; KRAB box
      pfam13465
      Location:407432
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001265599.2NP_001252528.1  zinc finger protein 211 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, initiates translation at a downstream, in-frame start codon and lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AC003682, AK294869, AK296942, BQ678885, DA961612
      Consensus CDS
      CCDS58687.1
      UniProtKB/Swiss-Prot
      Q13398
      Related
      ENSP00000254182.7, OTTHUMP00000237578, ENST00000254182.11, OTTHUMT00000397504
      Conserved Domains (4) summary
      COG5048
      Location:170541
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:446466
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:444466
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:346371
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001265600.2NP_001252529.1  zinc finger protein 211 isoform 6

      See identical proteins and their annotated locations for NP_001252529.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (6) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC003682, AK294869, AK304666, BQ678885, DA961612
      Consensus CDS
      CCDS58688.1
      UniProtKB/Swiss-Prot
      Q13398
      Related
      ENSP00000375584.3, OTTHUMP00000237579, ENST00000391703.3, OTTHUMT00000397505
      Conserved Domains (4) summary
      COG5048
      Location:234489
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:394414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:392414
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:294319
      zf-H2C2_2; Zinc-finger double domain
    5. NM_001322306.1NP_001309235.1  zinc finger protein 211

      Status: VALIDATED

      Source sequence(s)
      AC003682, BQ678885, DA961612
      Conserved Domains (4) summary
      COG5048
      Location:242613
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:516538
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:418443
      zf-H2C2_2; Zinc-finger double domain
    6. NM_006385.4NP_006376.2  zinc finger protein 211 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC003682, AK294869, BQ678885, DA745028, DA961612
      Consensus CDS
      CCDS12956.1
      UniProtKB/Swiss-Prot
      Q13398
      Related
      ENSP00000240731.4, OTTHUMP00000237582, ENST00000240731.4, OTTHUMT00000397509
      Conserved Domains (6) summary
      smart00349
      Location:4687
      KRAB; krueppel associated box
      COG5048
      Location:192563
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:468488
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:466488
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:4685
      KRAB; KRAB box
      pfam13465
      Location:368393
      zf-H2C2_2; Zinc-finger double domain
    7. NM_198855.3NP_942152.1  zinc finger protein 211 isoform 2

      See identical proteins and their annotated locations for NP_942152.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC003682, AK294869, AK304666, BC034351, BQ678885, DA961612
      Consensus CDS
      CCDS12957.1
      UniProtKB/Swiss-Prot
      Q13398
      Related
      ENSP00000339562.3, OTTHUMP00000237576, ENST00000347302.7, OTTHUMT00000397502
      Conserved Domains (6) summary
      smart00349
      Location:3374
      KRAB; krueppel associated box
      COG5048
      Location:179550
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:455475
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:453475
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:3372
      KRAB; KRAB box
      pfam13465
      Location:355380
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_049752.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) includes two alternate internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC003682, AK294869, BC018138, BQ678885, DA961612
    2. NR_049753.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC003682, AK294869, BC110856, BQ678885, DA961612
    3. NR_049754.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC003682, AK294869, AK297047, BQ678885, DA961612

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      57633167..57644046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001290231.1: Suppressed sequence

      Description
      NM_001290231.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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