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    Brk1 BRICK1, SCAR/WAVE actin-nucleating complex subunit [ Mus musculus (house mouse) ]

    Gene ID: 101314, updated on 5-Aug-2018

    Summary

    Official Symbol
    Brk1provided by MGI
    Official Full Name
    BRICK1, SCAR/WAVE actin-nucleating complex subunitprovided by MGI
    Primary source
    MGI:MGI:1915406
    See related
    Ensembl:ENSMUSG00000033940 Vega:OTTMUSG00000056403
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW011779; 6720456B07Rik
    Expression
    Ubiquitous expression in cortex adult (RPKM 93.6), frontal lobe adult (RPKM 90.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Brk1 in Genome Data Viewer
    Location:
    6; 6 E3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (113604772..113616951)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (113554766..113566945)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene Fanconi anemia, complementation group D2 Neighboring gene predicted gene, 46971 Neighboring gene Fancd2 opposite strand Neighboring gene von Hippel-Lindau tumor suppressor Neighboring gene interleukin-1 receptor-associated kinase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to Rac GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotrimerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SCAR complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein BRICK1
    Names
    probable protein BRICK1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133937.1NP_598698.1  protein BRICK1

      See identical proteins and their annotated locations for NP_598698.1

      Status: PROVISIONAL

      Source sequence(s)
      BC010582
      Consensus CDS
      CCDS39595.1
      UniProtKB/Swiss-Prot
      Q91VR8
      Related
      ENSMUSP00000041644.5, OTTMUSP00000073129, ENSMUST00000035725.6, OTTMUST00000139356

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      113604772..113616951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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