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    NR1I3 nuclear receptor subfamily 1 group I member 3 [ Homo sapiens (human) ]

    Gene ID: 9970, updated on 9-Sep-2018

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Results suggest that TRIM24 is a novel coactivator of the CAR that is involved in cell- and/or promoter- selective transactivation.

    Tripartite Motif Containing 24 Acts as a Novel Coactivator of the Constitutive Active/Androstane Receptor.
    Kanno Y, Kure Y, Kobayashi S, Mizuno M, Tsuchiya Y, Yamashita N, Nemoto K, Inouye Y.

    08/4/2018
    An overview of NR1I2 and NR1I3 pharmacogenetic studies in various therapeutic fields.

    Genetic variations of the xenoreceptors NR1I2 and NR1I3 and their effect on drug disposition and response variability.
    Mbatchi LC, Brouillet JP, Evrard A.

    07/28/2018
    replication confirmed at genome-wide significance the association of loci at FOXE1 with hypothyroidism, and PDE8B, CAPZB and PDE10A with serum TSH. A total of 12 SNPs seemed to explain nearly 7% of the serum TSH variation

    Analysis of common polymorphisms within NR1I2 and NR1I3 genes and tacrolimus dose-adjusted concentration in stable kidney transplant recipients.
    Kurzawski M, Malinowski D, Dziewanowski K, Droździk M.

    03/10/2018
    Dual ligands of CAR/PXR show distinct gene regulation patterns by regulating cross-talk between CAR and PXR.

    Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR.
    Kanno Y, Tanuma N, Yazawa S, Zhao S, Inaba M, Nakamura S, Nemoto K, Inouye Y.

    01/27/2018
    Data suggest both PXR and CAR are expressed in testis/Sertoli cells; exposure of Sertoli cells (in vitro model of blood-testis barrier) to PXR or CAR ligands (including antiretroviral drugs) up-regulates expression of Pgp/ABCB1, BCRP, and MRP4. (PXR = pregnane X receptor; CAR = constitutive androstane receptor; Pgp/ABCB1 = P-glycoprotein ABCB1; BCRP = breast cancer resistance protein; MRP4 =multidrug resistance protein 4)

    Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier.
    Whyte-Allman SK, Hoque MT, Jenabian MA, Routy JP, Bendayan R.

    11/26/2017
    Genome-wide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARalpha in primary human hepatocytes has been presented.

    Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes.
    Kandel BA, Thomas M, Winter S, Damm G, Seehofer D, Burk O, Schwab M, Zanger UM.

    06/3/2017
    These data provide new insights into the regulation by CAR of glycolytic and lipogenic genes and on pathogenesis of steatosis

    Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.
    Marmugi A, Lukowicz C, Lasserre F, Montagner A, Polizzi A, Ducheix S, Goron A, Gamet-Payrastre L, Gerbal-Chaloin S, Pascussi JM, Moldes M, Pineau T, Guillou H, Mselli-Lakhal L.

    05/27/2017
    Integrative analysis of four RNA-Seq datasets and differential expression revealed for the first time, splicing alterations of SLC39A14 and NR1I3 in hepatocellular carcinoma.

    Identification of important long non-coding RNAs and highly recurrent aberrant alternative splicing events in hepatocellular carcinoma through integrative analysis of multiple RNA-Seq datasets.
    Zhang L, Liu X, Zhang X, Chen R.

    01/28/2017
    These results reveal both novel and known targets of hCAR and support the role of hCAR in maintaining the homeostasis of metabolism and cell proliferation in the liver.

    Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells.
    Li D, Mackowiak B, Brayman TG, Mitchell M, Zhang L, Huang SM, Wang H., Free PMC Article

    02/13/2016
    The homozygous variant genotype of MPJ6_1I3008 is associated with a significant reduced risk of neonatal hyperbilirubinemia in females.

    High resolution melting analysis of the NR1I3 genetic variants: Is there an association with neonatal hyperbilirubinemia?
    Cheung TP, Van Rostenberghe H, Ismail R, Nawawi NN, Abdullah NA, Ramli N, Ibrahim NR, Hj Abd Majid N, Mohd Yusoff N, Nishio H, Yusoff S.

    12/19/2015
    Around 42.5% of the overall interindividual variability in warfarin dose requirements was explained : VKORC1 genotype accounted for 29.6%, CYP2C9 genotype for 4.3%, age for 3.6%, the CYP4F2 genotype for 3.3%, and CAR/HNF4alpha (rs2501873/rs3212198) for 1.7%

    Combined effects of hepatocyte nuclear factor 4α and constitutive androstane receptor on stable warfarin doses.
    Moon JY, Lee KE, Chang BC, Jeong E, Jeong H, Gwak HS.

    12/5/2015
    It is suggested that the functions of PXR, CAR and AhR may be closely implicated in the pathogeneses of metabolic vascular diseases, such as hyperlipidemia, atherogenesis, and hypertension.

    Roles of xenobiotic receptors in vascular pathophysiology.
    Xiao L, Zhang Z, Luo X.

    09/26/2015
    Suggest that PXR and CAR double humanized mice are more sensitive rifampcin induction of cytochrome P450 and UDP-glucuronosyltransferases.

    Expression of hepatic cytochrome P450s and UDP-glucuronosyltransferases in PXR and CAR double humanized mice treated with rifampicin.
    Lee SY, Lee JY, Kim YM, Kim SK, Oh SJ.

    07/4/2015
    PRMT5 enhances transcriptional activity of constitutive androstane receptor.PRMT5 is a gene-selective co-activator for CAR.

    Protein arginine methyltransferase 5 (PRMT5) is a novel coactivator of constitutive androstane receptor (CAR).
    Kanno Y, Inajima J, Kato S, Matsumoto M, Tokumoto C, Kure Y, Inouye Y.

    06/27/2015
    The nuclear receptor constitutive androstane receptor/NR1I3 enhances the profibrotic effects of transforming growth factor beta and contributes to the development of experimental dermal fibrosis.

    The nuclear receptor constitutive androstane receptor/NR1I3 enhances the profibrotic effects of transforming growth factor β and contributes to the development of experimental dermal fibrosis.
    Avouac J, Palumbo-Zerr K, Ruzehaji N, Tomcik M, Zerr P, Dees C, Distler A, Beyer C, Schneider H, Distler O, Schett G, Allanore Y, Distler JH.

    02/14/2015
    Donor CYP3A5, NR1I3 gene polymorphisms.

    Association of hemoglobin levels, CYP3A5, and NR1I3 gene polymorphisms with tacrolimus pharmacokinetics in liver transplant patients.
    Chen D, Guo F, Shi J, Zhang C, Wang Z, Fan J, Peng Z.

    02/14/2015
    ubiquitin-proteasomal regulation of CCRP and HSP70 are important contributors to the regulation of cytoplasmic CAR levels, and hence the ability of CAR to respond to PB or PB-like inducers

    Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system.
    Timsit YE, Negishi M., Free PMC Article

    12/27/2014
    The polymorphisms investigated in PPARA (rs1800206), RXRA (rs11381416), and NR1I2 (rs1523130) did not influence the lipid-lowering efficacy and safety of statin and our results show the possible influence of NR1I3 genetic variant on the safety of statin.

    Influence of PPARA, RXRA, NR1I2 and NR1I3 gene polymorphisms on the lipid-lowering efficacy and safety of statin therapy.
    Lima LO, Bruxel EM, Hutz MH, Van der Sand CR, Van der Sand LC, Ferreira ME, Pires RC, Fiegenbaum M, Almeida S.

    10/4/2014
    miR-137 is a crucial regulator of cancer response to doxorubicin treatment

    miR-137 regulates the constitutive androstane receptor and modulates doxorubicin sensitivity in parental and doxorubicin-resistant neuroblastoma cells.
    Takwi AA, Wang YM, Wu J, Michaelis M, Cinatl J, Chen T., Free PMC Article

    09/6/2014
    The CAR variant, which results in a poor metabolizer phenotype, could account for a higher degree of external genitalia virilization in 21OHD females.

    The effect of fetal androgen metabolism-related gene variants on external genitalia virilization in congenital adrenal hyperplasia.
    Kaupert LC, Lemos-Marini SH, De Mello MP, Moreira RP, Brito VN, Jorge AA, Longui CA, Guerra G Jr, Mendonca BB, Bachega TA.

    06/7/2014
    Gadd45B protects the liver through two entirely different processes: binding MKK7 to block damaging signal transduction or binding CAR to coactivate anabolic transcription. (Review)

    Gadd45 in the liver: signal transduction and transcriptional mechanisms.
    Tian J, Locker J.

    02/22/2014
    Activated p38 MAPK is required for CAR to selectively activate a set of genes that encode drug-metabolizing enzymes.

    p38 Mitogen-activated protein kinase regulates nuclear receptor CAR that activates the CYP2B6 gene.
    Saito K, Moore R, Negishi M., Free PMC Article

    02/8/2014
    Common genetic variants in the xenobiotic transport and metabolism regulator genes PXR and CAR do not have a significant association with multiple myeloma risk.

    Polymorphisms in regulators of xenobiotic transport and metabolism genes PXR and CAR do not affect multiple myeloma risk: a case-control study in the context of the IMMEnSE consortium.
    Martino A, Sainz J, Manuel Reis R, Moreno V, Buda G, Lesueur F, Marques H, García-Sanz R, Ríos R, Stein A, Dumontet C, Gemignani F, Maria Rossi A, Landi S, Jurado M, Petrini M, Jamroziak K, Campa D, Canzian F.

    11/30/2013
    CYP2B6 516G>T (P < 0.0001) and CAR rs2307424 C>T (P = 0.002) were significantly related to efavirenz plasma concentrations.

    Correlates of efavirenz exposure in Chilean patients affected with human immunodeficiency virus reveals a novel association with a polymorphism in the constitutive androstane receptor.
    Cortes CP, Siccardi M, Chaikan A, Owen A, Zhang G, la Porte CJ.

    09/28/2013
    Constitutive androstane receptor-mediated enzyme induction in the liver depends on the presence of beta-catenin at the time of xenobiotic treatment.

    The time point of β-catenin knockout in hepatocytes determines their response to xenobiotic activation of the constitutive androstane receptor.
    Ganzenberg K, Singh Y, Braeuning A.

    08/31/2013
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