| Nuclear pore protein POM121 regulates subcellular localization and transcriptional activity of PPARgamma. | Nuclear pore protein POM121 regulates subcellular localization and transcriptional activity of PPARĪ³.
Yu Y, Farooq MS, Eberhart Meessen S, Jiang Y, Kato D, Zhan T, Weiss C, Seger R, Kang W, Zhang X, Yu J, Ebert MPA, Burgermeister E., Free PMC Article | 01/11/2024 |
| Up-regulation of POM121 is linked to prostate cancer aggressiveness and serves as a prognostic biomarker. | Up-regulation of POM121 is linked to prostate cancer aggressiveness and serves as a prognostic biomarker.
Becker F, Offermann A, Roesch MC, Joerg V, Roth D, Lubczyk V, Kuefer R, Sailer V, Kirfel J, Merseburger AS, Perner S. | 07/23/2022 |
| POM121 is a novel marker for predicting the prognosis of laryngeal cancer. | POM121 is a novel marker for predicting the prognosis of laryngeal cancer.
Zhao R, Tang G, Wang T, Zhang L, Wang W, Zhao Q, Zhao K. | 10/16/2021 |
| Clinical Significance of POM121 Expression in Lung Cancer. | Clinical Significance of POM121 Expression in Lung Cancer.
Zhang S, Zheng C, Li D, Bei C, Zhang H, Tian R, Song X, Zhu X, Tan S. | 07/17/2021 |
| POM121 overexpression is related to a poor prognosis in colorectal cancer. | POM121 overexpression is related to a poor prognosis in colorectal cancer.
Wang T, Sun H, Bao Y, En R, Tian Y, Zhao W, Jia L. | 06/5/2021 |
| G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD. | G(4)C(2) Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.
Coyne AN, Zaepfel BL, Hayes L, Fitchman B, Salzberg Y, Luo EC, Bowen K, Trost H, Aigner S, Rigo F, Yeo GW, Harel A, Svendsen CN, Sareen D, Rothstein JD., Free PMC Article | 11/21/2020 |
| POM121 promotes prostate cancer progression by enhancing importin-dependent nuclear transport of key oncogenic (E2F1, MYC) and prostate cancer-specific (AR-GATA2) transcription factors | Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import.
Rodriguez-Bravo V, Pippa R, Song WM, Carceles-Cordon M, Dominguez-Andres A, Fujiwara N, Woo J, Koh AP, Ertel A, Lokareddy RK, Cuesta-Dominguez A, Kim RS, Rodriguez-Fernandez I, Li P, Gordon R, Hirschfield H, Prats JM, Reddy EP, Fatatis A, Petrylak DP, Gomella L, Kelly WK, Lowe SW, Knudsen KE, Galsky MD, Cingolani G, Lujambio A, Hoshida Y, Domingo-Domenech J., Free PMC Article | 05/18/2019 |
| Taken together, these results showed that full-length Pom121 enables efficient HIV-1 pre-integration complex nuclear import, and suggested that this process may rely on KPNB1 dependent classical cargo nuclear transportation way. | The transmembrane nucleoporin Pom121 ensures efficient HIV-1 pre-integration complex nuclear import.
Guo J, Liu X, Wu C, Hu J, Peng K, Wu L, Xiong S, Dong C., Free PMC Article | 05/18/2019 |
| findings implicate alternate transcription initiation as a mechanism to increase the functional diversity of NPC components, such as POM121 | Evolution of a transcriptional regulator from a transmembrane nucleoporin.
Franks TM, Benner C, Narvaiza I, Marchetto MC, Young JM, Malik HS, Gage FH, Hetzer MW., Free PMC Article | 02/25/2017 |
| The conserved features of the NLSs of ScHeh1, ScHeh2, and RnPom121 and the effective sorting of Heh2-derived reporters in human cells suggest that active import is conserved but confined to a small subset of INM proteins. | Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins.
Kralt A, Jagalur NB, van den Boom V, Lokareddy RK, Steen A, Cingolani G, Fornerod M, Veenhoff LM., Free PMC Article | 07/2/2016 |
| Data suggest that the nuclear migration of Pom121 and its subsequent interaction with inner nuclear membrane proteins are required to initiate interphase nuclear pore complex assembly. | Localization of Pom121 to the inner nuclear membrane is required for an early step of interphase nuclear pore complex assembly.
Funakoshi T, Clever M, Watanabe A, Imamoto N., Free PMC Article | 12/10/2011 |
| The the N terminus of Pom121 directly binds the beta-propeller regions of Nup155 and Nup160. | Pom121 links two essential subcomplexes of the nuclear pore complex core to the membrane.
Mitchell JM, Mansfeld J, Capitanio J, Kutay U, Wozniak RW., Free PMC Article | 12/11/2010 |
| The nuclear localization signal sites of Pom121 affect its function in nuclear pore complex assembly both by influencing nucleoporin interactions and pore membrane structure. | NLS-mediated NPC functions of the nucleoporin Pom121.
Yavuz S, Santarella-Mellwig R, Koch B, Jaedicke A, Mattaj IW, Antonin W. | 09/20/2010 |
| RNAi experiments showed that efficient depletion of both Pom121 proteins significantly reduces assembled nuclear pore complexes on nuclear envelope. | Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes.
Funakoshi T, Maeshima K, Yahata K, Sugano S, Imamoto F, Imamoto N. | 01/21/2010 |