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    DDX18 DEAD-box helicase 18 [ Homo sapiens (human) ]

    Gene ID: 8886, updated on 17-Jun-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Data show that odulation of RNA helicase DDX18 directly affects growth of tamoxifen-resistant cells, suggesting that it may be a critical downstream effector of the estrogen receptors (ERs) and high mobility group box 2 (HMGB2) complex.

    Genomic interaction between ER and HMGB2 identifies DDX18 as a novel driver of endocrine resistance in breast cancer cells.
    Redmond AM, Byrne C, Bane FT, Brown GD, Tibbitts P, O'Brien K, Hill AD, Carroll JS, Young LS.

    We identified 4 nonsynonymous sequence variants of DDX18 in acute myeloid leukemia patient samples

    Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML.
    Payne EM, Bolli N, Rhodes J, Abdel-Wahab OI, Levine R, Hedvat CV, Stone R, Khanna-Gupta A, Sun H, Kanki JP, Gazda HT, Beggs AH, Cotter FE, Look AT., Free PMC Article

    Observational study of gene-disease association. (HuGE Navigator)

    Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.
    Wang X, Chorley BN, Pittman GS, Kleeberger SR, Brothers J 2nd, Liu G, Spira A, Bell DA., Free PMC Article

    findings suggest that MrDb is important for cell proliferation and that its inhibition could prevent tumor cell proliferation.

    Cellular studies of MrDb (DDX18).
    Dubaele S, Chène P.

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