| Hepatitis B Virus (HBV) Upregulates TRAIL-R3 Expression in Hepatocytes Resulting in Escape From Both Cell Apoptosis and Suppression of HBV Replication by TRAIL. | Hepatitis B Virus (HBV) Upregulates TRAIL-R3 Expression in Hepatocytes Resulting in Escape From Both Cell Apoptosis and Suppression of HBV Replication by TRAIL.
Suehiro Y, Tsuge M, Kurihara M, Uchida T, Fujino H, Ono A, Yamauchi M, Naswa Makokha G, Nakahara T, Murakami E, Abe-Chayama H, Kawaoka T, Miki D, Imamura M, Aikata H, Nelson Hayes C, Fujita T, Chayama K. | 03/6/2023 |
| TRAIL receptors are differentially regulated and clinically significant in gallbladder cancer. | TRAIL receptors are differentially regulated and clinically significant in gallbladder cancer.
Singh D, Prasad CB, Biswas D, Tewari M, Kar AG, Ansari MA, Singh S, Narayan G. | 12/19/2020 |
| High levels of TRAIL-R3 and CCR-2 expression in tumor epithelial cells identified patients with early breast cancer with poor outcomes. | Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer.
Labovsky V, Martinez LM, Davies KM, de Luján Calcagno M, García-Rivello H, Wernicke A, Feldman L, Matas A, Giorello MB, Borzone FR, Choi H, Howard SC, Chasseing NA., Free PMC Article | 04/29/2017 |
| Results identified epigenetic inactivation of TNFRSF10C and TNFRSF10D in majority of cervical cancer cases. | Epigenetic inactivation of TRAIL decoy receptors at 8p12-21.3 commonly deleted region confers sensitivity to Apo2L/trail-Cisplatin combination therapy in cervical cancer.
Narayan G, Xie D, Ishdorj G, Scotto L, Mansukhani M, Pothuri B, Wright JD, Kaufmann AM, Schneider A, Arias-Pulido H, Murty VV. | 10/22/2016 |
| DcRs regulate TRAIL sensitivity at a supracellular level | Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.
O'Leary L, van der Sloot AM, Reis CR, Deegan S, Ryan AE, Dhami SP, Murillo LS, Cool RH, Correa de Sampaio P, Thompson K, Murphy G, Quax WJ, Serrano L, Samali A, Szegezdi E. | 07/30/2016 |
| DcR1 levels in serum sample which were significantly lower in AMD patients. | Does DcR1 (TNF-related apoptosis-inducing-ligand Receptor 3) have any role in human AMD pathogenesis?
Anand A, Sharma NK, Singh R, Gupta A, Prabhakar S, Jindal N, Bhatt AK, Sharma SK, Gupta PK., Free PMC Article | 10/24/2015 |
| DcR1 upregulation mediates temozolomide resistance. | Decoy Receptor DcR1 Is Induced in a p50/Bcl3-Dependent Manner and Attenuates the Efficacy of Temozolomide.
Mansour NM, Bernal GM, Wu L, Crawley CD, Cahill KE, Voce DJ, Balyasnikova IV, Zhang W, Spretz R, Nunez L, Larsen GF, Weichselbaum RR, Yamini B., Free PMC Article | 08/1/2015 |
| membrane expression more common in endometrioid endometrial cancer than in normal endometrium | Membrane expression of trail receptors DcR1 and DcR2 in the normal endometrium, endometrial atypical hyperplasia and endometrioid endometrial cancer.
Gottwald L, Pasz-Walczak G, Piekarski J, Szwalski J, Kubiak R, Spych M, Suzin J, Tyliński W, Sęk P, Jeziorski A. | 04/18/2015 |
| The membrane expression of the TRAIL receptors DR4, DR5, DcR1 and DcR2 is greater in normal endometrium than endometrioid adenocarcinoma (EAC). The level of the receptors in EAC is not dependent on grading and staging and does not predict survival. | Membrane expression of TRAIL receptors DR4, DR5, DcR1 and DcR2 in the normal endometrium, atypical endometrial hyperplasia and endometrioid adenocarcinoma: a tissue microarray study.
Gottwald L, Piekarski J, Kubiak R, Szwalski J, Pasz-Walczak G, Sęk P, Spych M, Suzin J, Tyliński W, Jeziorski A., Free PMC Article | 05/24/2014 |
| the results presented here claim for a relevant impact of aberrant methylation of decoy receptors in melanoma and allow to understand how the silencing of DcR1 and DcR2 is related to melanomagenesis. | Impact of DNA methyltransferases on the epigenetic regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor expression in malignant melanoma.
Venza M, Visalli M, Catalano T, Fortunato C, Oteri R, Teti D, Venza I. | 04/5/2014 |
| GATA4 and DcR1 promoter hypermethylation is tumor specific event in glioblastoma but they promoter methylation cannot be considered as a prognostic marker of glioblastoma survival. | GATA4 and DcR1 methylation in glioblastomas.
Vaitkienė P, Skiriutė D, Skauminas K, Tamašauskas A., Free PMC Article | 06/29/2013 |
| Primary EOC is associated to a lower TRAIL-R3 expression. | TRAIL-R3-related apoptosis: epigenetic and expression analyses in women with ovarian neoplasia.
Braga Lda C, Alvares da Silva Ramos AP, Traiman P, Silva LM, Lopes da Silva-Filho A. | 11/17/2012 |
| Data show that about 20% of AML patients highly expressed decoy receptor TRAIL-R3, which was strongly correlated to a shortened overall survival. | High TRAIL-R3 expression on leukemic blasts is associated with poor outcome and induces apoptosis-resistance which can be overcome by targeting TRAIL-R2.
Chamuleau ME, Ossenkoppele GJ, van Rhenen A, van Dreunen L, Jirka SM, Zevenbergen A, Schuurhuis GJ, van de Loosdrecht AA. | 12/10/2011 |
| Decoy receptors DcR1 and DcR2 on CD8+ T cells, but not on CD4-positive T cells, are positively correlated with patients' DAS scores. | TRAIL death receptor-4, decoy receptor-1 and decoy receptor-2 expression on CD8+ T cells correlate with the disease severity in patients with rheumatoid arthritis.
Bisgin A, Terzioglu E, Aydin C, Yoldas B, Yazisiz V, Balci N, Bagci H, Gorczynski RM, Akdis CA, Sanlioglu S., Free PMC Article | 06/18/2011 |
| Results suggest that DcR1 expression occurs in a subset of endometrial carcinomas and may contribute to resistance to TRAIL-induced apoptosis. | DcR1 expression in endometrial carcinomas.
Tarragona J, Llecha N, Santacana M, Lopez S, Gatius S, Llobet D, Dolcet X, Palomar-Asenjo V, Gonzalez-Tallada FJ, Matias-Guiu X. | 02/8/2010 |
| Low DCR1 is associated with non-small cell lung cancer. | Cytotoxic effects of camptothecin and cisplatin combined with tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) in a model of primary culture of non-small cell lung cancer.
Frese S, Schüller A, Frese-Schaper M, Gugger M, Schmid RA. | 01/21/2010 |
| Liver metastases with low DcR1/TNFRSF10C mRNA expression were more likely to present with extrahepatic metastases | Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level.
Macartney-Coxson DP, Hood KA, Shi HJ, Ward T, Wiles A, O'Connor R, Hall DA, Lea RA, Royds JA, Stubbs RS, Rooker S., Free PMC Article | 01/21/2010 |
| inactivation of TNFRSF10C by chromosomal deletion and promoter methylation may play an important role in prostate cancer development | Genetic and epigenetic inactivation of TNFRSF10C in human prostate cancer.
Cheng Y, Kim JW, Liu W, Dunn TA, Luo J, Loza MJ, Kim ST, Zheng SL, Xu J, Isaacs WB, Chang BL., Free PMC Article | 01/21/2010 |
| These data strongly support a recent proposal that a segment at 8p21.3 contains crucial prostate cancer tumor suppressors. | Protein phosphatase and TRAIL receptor genes as new candidate tumor genes on chromosome 8p in prostate cancer.
Hornstein M, Hoffmann MJ, Alexa A, Yamanaka M, Müller M, Jung V, Rahnenführer J, Schulz WA. | 01/21/2010 |
| TRAILR3 (TNF-related apoptosis inducing ligand receptor 3) levels were significantly higher in lung parenchyma in subjects with emphysema | Increased p53 level, Bax/Bcl-x(L) ratio, and TRAIL receptor expression in human emphysema.
Morissette MC, Vachon-Beaudoin G, Parent J, Chakir J, Milot J. | 01/21/2010 |
| p53 negatively regulates oxaliplatin-mediated TRAIL-induced apoptotic activity through DcR1 upregulation. | P53-mediated upregulation of DcR1 impairs oxaliplatin/TRAIL-induced synergistic anti-tumour potential in colon cancer cells.
Toscano F, Fajoui ZE, Gay F, Lalaoui N, Parmentier B, Chayvialle JA, Scoazec JY, Micheau O, Abello J, Saurin JC. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (5) articlesCommon single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.
Lee KM, Baris D, Zhang Y, Hosgood HD 3rd, Menashe I, Yeager M, Zahm SH, Wang SS, Purdue MP, Chanock S, Zheng T, Rothman N, Lan Q. New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD 3rd, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q. Common genetic variants in candidate genes and risk of familial lymphoid malignancies.
Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR. Polymorphisms in TRAIL receptor genes and risk of breast cancer in Spanish women.
Martinez-Ferrandis JI, Rodríguez-López R, Milne RL, González E, Cebolla E, Chirivella I, Zamora P, Arias JI, Palacios S, Cervantes A, Díez O, Benitez J, Armengod ME. | 03/13/2008 |
| Observational study of genotype prevalence. (HuGE Navigator) | Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population.
Cho SM, Kim J, Ryu HJ, Kim JJ, Kim HH, Park JH, Kim HT, Kim KH, Cho HY, Oh B, Park C, Kimm K, Jo I, Lee JE, Shin HD, Lee JK. | 03/13/2008 |
| tryptophol induces apoptosis through DR5 and the resistance of PBL to tryptophol-induced apoptosis might be due to competition from DcR1 | Tryptophol induces death receptor (DR) 5-mediated apoptosis in U937 cells.
Inagaki S, Morimura S, Tang Y, Akutagawa H, Kida K. | 01/21/2010 |
| Resistance to TRAIL-induced apoptosis in acute myeloid leukemia cells is associated with expression of TRAIL-R3. | TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL.
Riccioni R, Pasquini L, Mariani G, Saulle E, Rossini A, Diverio D, Pelosi E, Vitale A, Chierichini A, Cedrone M, Foà R, Lo Coco F, Peschle C, Testa U. | 01/21/2010 |