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    PIAS1 protein inhibitor of activated STAT 1 [ Homo sapiens (human) ]

    Gene ID: 8554, updated on 26-Jun-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    A novel function of p14ARF to inhibit PIAS1 by enhancing SUMOylation.

    Tumor Suppressor p14ARF Enhances IFN-γ-Activated Immune Response by Inhibiting PIAS1 via SUMOylation.
    Alagu J, Itahana Y, Sim F, Chao SH, Bi X, Itahana K.

    06/22/2019
    These findings demonstrate the crucial role of PIAS1-mediated PPARgamma SUMOylation in protecting against myocardial ischemia-reperfusion injury.

    PIAS1 protects against myocardial ischemia-reperfusion injury by stimulating PPARγ SUMOylation.
    Xie B, Liu X, Yang J, Cheng J, Gu J, Xue S., Free PMC Article

    06/1/2019
    Rad18, independently of its ubiquitin ligase activity, promotes DNA polymerase eta SUMOylation by facilitating its interaction with its SUMO ligase PIAS1 and is required for DNA polymerase eta function at difficult to replicate loci.

    Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA.
    Despras E, Sittewelle M, Pouvelle C, Delrieu N, Cordonnier AM, Kannouche PL., Free PMC Article

    09/8/2018
    PIAS1 as a key regulator of Epstein-Barr Virus lytic replication. PIAS1 acts as an inhibitor for transcription factors involved in lytic gene expression.

    B Cell Receptor Activation and Chemical Induction Trigger Caspase-Mediated Cleavage of PIAS1 to Facilitate Epstein-Barr Virus Reactivation.
    Zhang K, Lv DW, Li R., Free PMC Article

    07/21/2018
    these results indicate that PIAS1 is a positive regulator of MYC.

    PIAS1 Promotes Lymphomagenesis through MYC Upregulation.
    Rabellino A, Melegari M, Tompkins VS, Chen W, Van Ness BG, Teruya-Feldstein J, Conacci-Sorrell M, Janz S, Scaglioni PP., Free PMC Article

    09/23/2017
    PIAS1 is a prognostic biomarker in breast cancer

    Identification of the SUMO E3 ligase PIAS1 as a potential survival biomarker in breast cancer.
    Chanda A, Chan A, Deng L, Kornaga EN, Enwere EK, Morris DG, Bonni S., Free PMC Article

    09/16/2017
    PIAS1 is a determinant of poor survival and acts as a positive feedback regulator of AR signaling through enhanced AR stabilization in prostate cancer

    PIAS1 is a determinant of poor survival and acts as a positive feedback regulator of AR signaling through enhanced AR stabilization in prostate cancer.
    Puhr M, Hoefer J, Eigentler A, Dietrich D, van Leenders G, Uhl B, Hoogland M, Handle F, Schlick B, Neuwirt H, Sailer V, Kristiansen G, Klocker H, Culig Z., Free PMC Article

    09/2/2017
    PIAS1 overexpression exacerbated mutant Huntingtin-associated phenotypes and aberrant protein accumulation

    PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington's Disease-Associated Phenotypes In Vivo.
    Ochaba J, Monteys AM, O'Rourke JG, Reidling JC, Steffan JS, Davidson BL, Thompson LM., Free PMC Article

    08/26/2017
    HBs protein-induced hPIAS1 transcription requires TAL1, E47, MYOG, NFI, and MAPK signal pathways

    Hepatitis B virus surface protein-induced hPIAS1 transcription requires TAL1, E47, MYOG, NFI, and MAPK signal pathways.
    Wang H, Wu D, Wang X, Chen G, Zhang Y, Yan W, Luo X, Han M, Ning Q.

    07/8/2017
    identified the SUMO ligase PIAS1 as a constituent PML-NB antiviral protein. This finding distinguishes a SUMO ligase that may mediate signaling events important in promyelocytic leukemia nuclear body mediated intrinsic immunity.

    SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1.
    Brown JR, Conn KL, Wasson P, Charman M, Tong L, Grant K, McFarlane S, Boutell C., Free PMC Article

    05/13/2017
    PIAS1 enhances p300 recruitment to c-Myb-bound sites through interaction with both proteins. In addition, the E3 activity of PIAS1 enhances further its coactivation

    PIAS1 binds p300 and behaves as a coactivator or corepressor of the transcription factor c-Myb dependent on SUMO-status.
    Ledsaak M, Bengtsen M, Molværsmyr AK, Fuglerud BM, Matre V, Eskeland R, Gabrielsen OS.

    08/6/2016
    Results show that apocrine breast cancer and prostate cancer cells share a core AR cistrome and target gene signature linked to cancer cell growth, and PIAS1 plays a similar coregulatory role for AR in both cancer cell types.

    Androgen receptor- and PIAS1-regulated gene programs in molecular apocrine breast cancer cells.
    Malinen M, Toropainen S, Jääskeläinen T, Sahu B, Jänne OA, Palvimo JJ.

    06/4/2016
    c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4

    c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4.
    González-Prieto R, Cuijpers SA, Kumar R, Hendriks IA, Vertegaal AC., Free PMC Article

    04/23/2016
    Data demonstrate that PIAS1 interacts with TRF2 and mediates its sumoylation serving as a molecular switch that controls the level of TRF2 at telomeres.

    PIAS1-mediated sumoylation promotes STUbL-dependent proteasomal degradation of the human telomeric protein TRF2.
    Her J, Jeong YY, Chung IK.

    03/19/2016
    the expression of SENP8, SAE1, PIAS1, PIAS2 and ZMIZ1 is deregulated in the majority of PTC tissues, likely contributing to the PTC phenotype.

    PAPILLARY THYROID CANCER IS CHARACTERIZED BY ALTERED EXPRESSION OF GENES INVOLVED IN THE SUMOYLATION PROCESS.
    Tuccilli C, Baldini E, Sorrenti S, Di Gioia C, Bosco D, Ascoli V, Mian C, Barollo S, Rendina R, Coccaro C, Pepe M, Catania A, Bononi M, Tartaglia F, De Antoni E, D'Armiento M, Ulisse S.

    11/21/2015
    Our data suggest that necdin suppresses PIAS1 both by inhibiting SUMO E3 ligase activity and by promoting ubiquitin-dependent degradation.

    Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase.
    Gur I, Fujiwara K, Hasegawa K, Yoshikawa K., Free PMC Article

    10/10/2015
    the presented data indicate that PIAS1 is crucial for parental and docetaxel resistant prostate cancer cell survival

    PIAS1 is a crucial factor for prostate cancer cell survival and a valid target in docetaxel resistant cells.
    Puhr M, Hoefer J, Neuwirt H, Eder IE, Kern J, Schäfer G, Geley S, Heidegger I, Klocker H, Culig Z., Free PMC Article

    10/3/2015
    Elevated PIAS1 expression was observed in breast tumor samples.

    PIAS1 regulates breast tumorigenesis through selective epigenetic gene silencing.
    Liu B, Tahk S, Yee KM, Yang R, Yang Y, Mackie R, Hsu C, Chernishof V, O'Brien N, Jin Y, Fan G, Lane TF, Rao J, Slamon D, Shuai K., Free PMC Article

    12/27/2014
    PIAS1 is the E3 ligase responsible for SUMOylation of HMGN2.

    High mobility group nucleosomal binding domain 2 (HMGN2) SUMOylation by the SUMO E3 ligase PIAS1 decreases the binding affinity to nucleosome core particles.
    Wu J, Kim S, Kwak MS, Jeong JB, Min HJ, Yoon HG, Ahn JH, Shin JS., Free PMC Article

    10/11/2014
    Further study indicated that PIAS1 interacted with IRF3 and inhibited the DNA binding activity of IRF3.

    PIAS1 negatively modulates virus triggered type I IFN signaling by blocking the DNA binding activity of IRF3.
    Li R, Pan Y, Shi DD, Zhang Y, Zhang J.

    06/7/2014
    Levels of STAT1 andor the protein expression of its negative regulators, PIAS1 and SOCS3, may be a good predictor of hepatitis C virus response to therapy

    The role of hepatic expression of STAT1, SOCS3 and PIAS1 in the response of chronic hepatitis C patients to therapy.
    El-Saadany S, Ziada DH, El Bassat H, Farrag W, El-Serogy H, Eid M, Abdallah M, Ghazy M, Salem HA., Free PMC Article

    05/24/2014
    Smad2 and PIAS1 proteins were significantly upregulated resulting in dramatically increased interactions between Smad2/4 and PIAS1 in the presence of zinc.

    PIAS1-modulated Smad2/4 complex activation is involved in zinc-induced cancer cell apoptosis.
    Yang N, Zhao B, Rasul A, Qin H, Li J, Li X., Free PMC Article

    03/15/2014
    Phosphorylation of serine residues adjacent to the PIAS1 SUMO-interacting motif favors formation of the non covalent PIAS1.SUMO.UBC9 ternary complex

    Identification of a non-covalent ternary complex formed by PIAS1, SUMO1, and UBC9 proteins involved in transcriptional regulation.
    Mascle XH, Lussier-Price M, Cappadocia L, Estephan P, Raiola L, Omichinski JG, Aubry M., Free PMC Article

    03/8/2014
    Data suggest that the pro-apoptotic protein Daxx specifically interacts with one or more substrates SUMOylated by PIAS1 and this interaction leads to apoptosis following UV irradiation.

    The SUMO ligase PIAS1 regulates UV-induced apoptosis by recruiting Daxx to SUMOylated foci.
    Sudharsan R, Azuma Y., Free PMC Article

    08/31/2013
    data suggest that PIAS1 may function as a tumor suppressor to regulate gastric cancer cell metastasis by targeting the MAPK signaling pathway

    Protein inhibitor of activated STAT-1 is downregulated in gastric cancer tissue and involved in cell metastasis.
    Chen P, Zhao D, Sun Y, Huang L, Zhang S, Yuan Y.

    04/20/2013
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