The Sumo proteome of proliferating and neuronal-differentiating cells reveals Utf1 among key Sumo targets involved in neurogenesis. | The Sumo proteome of proliferating and neuronal-differentiating cells reveals Utf1 among key Sumo targets involved in neurogenesis. Correa-Vázquez JF, Juárez-Vicente F, García-Gutiérrez P, Barysch SV, Melchior F, García-Domínguez M., Free PMC Article | 10/16/2021 |
With a sensitivity of 100% and a specificity of 97% in the detection of central nervous system (CNS) germinomas, UTF1 serves as a new reliable alternative in the diagnostic setting of CNS germ cell tumours. | The embryonic stem cell factor UTF1 serves as a reliable diagnostic marker for germinomas. Pantazis G, Harter PN, Capper D, Kohlhof P, Mittelbronn M, Schittenhelm J. | 04/18/2015 |
UTF1 attenuates cell proliferation and is inactivated in cervical carcinogenesis through epigenetic modification. | Undifferentiated embryonic cell transcription factor-1 (UTF1) inhibits the growth of cervical cancer cells by transactivating p27Kip1. Wu XL, Zheng PS. | 09/7/2013 |
These findings strongly suggest that UTF1 promoter methylation profile might be a useful biomarker for cervical cancer diagnosis. | Aberrant promoter methylation and expression of UTF1 during cervical carcinogenesis. Guenin S, Mouallif M, Deplus R, Lampe X, Krusy N, Calonne E, Delbecque K, Kridelka F, Fuks F, Ennaji MM, Delvenne P., Free PMC Article | 01/12/2013 |
Utf1 couples the core pluripotency factors with Myc and PRC2 networks to promote the pluripotency and proliferation of embryonic stem cells. | Regulation of pluripotency and self- renewal of ESCs through epigenetic-threshold modulation and mRNA pruning. Jia J, Zheng X, Hu G, Cui K, Zhang J, Zhang A, Jiang H, Lu B, Yates J 3rd, Liu C, Zhao K, Zheng Y., Free PMC Article | 01/12/2013 |
role for UTF1 in differentiation of matrix cells of the shaft as well as in suprabasal keratinocytes. | Embryonic stem cell factors undifferentiated transcription factor-1 (UFT-1) and reduced expression protein-1 (REX-1) are widely expressed in human skin and may be involved in cutaneous differentiation but not in stem cell fate determination. Reinisch CM, Mildner M, Petzelbauer P, Pammer J., Free PMC Article | 12/17/2011 |
Human UTF1 is a tightly DNA-associated protein with transcriptional repressor activity. | Characterization of human UTF1, a chromatin-associated protein with repressor activity expressed in pluripotent cells. Kooistra SM, Thummer RP, Eggen BJ. | 04/23/2011 |
Strong UTF1 staining can be used for diagnosing embryonal carcinoma and seminoma. UTF1 expression in spermatogonia suggests its possible role in spermatogenesis and renewal of spermatogonia. | Expression of UTF1 in primary and metastatic testicular germ cell tumors. Wang P, Li J, Allan RW, Guo CC, Peng Y, Cao D. | 10/23/2010 |
Single SNPs did not alter the chromatin association and mobility of hUTF1; however, the double mutant, G73R/L275M, demonstrated a decreased chromatin association, indicating a degree of protein malfunction. | Functional characterization of single-nucleotide polymorphisms in the human undifferentiated embryonic-cell transcription factor 1 gene. Thummer RP, Drenth-Diephuis LJ, Carney KE, Eggen BJ. | 05/31/2010 |
enhances reprogramming efficiency of pluripotent stem cells generation induced from human adult fibroblasts | Two supporting factors greatly improve the efficiency of human iPSC generation. Zhao Y, Yin X, Qin H, Zhu F, Liu H, Yang W, Zhang Q, Xiang C, Hou P, Song Z, Liu Y, Yong J, Zhang P, Cai J, Liu M, Li H, Li Y, Qu X, Cui K, Zhang W, Xiang T, Wu Y, Zhao Y, Liu C, Yu C, Yuan K, Lou J, Ding M, Deng H. | 01/21/2010 |
The expression pattern indicated that UTF-1 plays a possible role in spermatogonial self-renewal | Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. Kristensen DM, Nielsen JE, Skakkebaek NE, Graem N, Jacobsen GK, Rajpert-De Meyts E, Leffers H. | 01/21/2010 |