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    UXT ubiquitously expressed prefoldin like chaperone [ Homo sapiens (human) ]

    Gene ID: 8409, updated on 10-Oct-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells.

    UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells.
    Sánchez-Morgan N, Kirsch KH, Trackman PC, Sonenshein GE.

    12/30/2017
    EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus.

    The EZH1-SUZ12 complex positively regulates the transcription of NF-κB target genes through interaction with UXT.
    Su SK, Li CY, Lei PJ, Wang X, Zhao QY, Cai Y, Wang Z, Li L, Wu M.

    08/5/2017
    we describe the identification of UXT as a novel MDMX-interacting protein

    UXT, a novel MDMX-binding protein, promotes glycolysis by mitigating p53-mediated restriction of NF-κB activity.
    Qi M, Ganapathy S, Zeng W, Zhang J, Little JB, Yuan ZM., Free PMC Article

    05/21/2016
    UXT is a binding protein of PIAS2, and interaction between PIAS2 and UXT may be important for the transcriptional activation of AR.

    Ubiquitously expressed transcript is a novel interacting protein of protein inhibitor of activated signal transducer and activator of transcription 2.
    Kong X, Ma S, Guo J, Ma Y, Hu Y, Wang J, Zheng Y., Free PMC Article

    09/26/2015
    Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes.

    Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes.
    Carter DR, Buckle AD, Tanaka K, Perdomo J, Chong BH., Free PMC Article

    01/3/2015
    Knockdown of UXT expression in Treg cells results in a less-suppressive phenotype.

    UXT is a novel regulatory factor of regulatory T cells associated with Foxp3.
    Li W, Wang L, Jiang C, Li H, Zhang K, Xu Y, Hao Q, Li M, Xue X, Qin X, Zhang C, Wang H, Zhang W, Zhang Y., Free PMC Article

    04/26/2014
    VHL-UXT interaction and VHL-induced ubiquitination of androgen receptor(AR) regulate transcriptional activation of the AR.

    Regulation of the transcriptional activation of the androgen receptor by the UXT-binding protein VHL.
    Chen S, Chen K, Zhang Q, Cheng H, Zhou R.

    12/28/2013
    Data found that the UXT isoforms elicit dual opposing regulatory effects on SARM-induced apoptosis.

    UXT plays dual opposing roles on SARM-induced apoptosis.
    Sethurathinam S, Singh LP, Panneerselvam P, Byrne B, Ding JL.

    11/23/2013
    Epstein-Barr virus BGLF4 kinase downregulates NF-kappaB transactivation through phosphorylation of coactivator UXT

    Epstein-Barr virus BGLF4 kinase downregulates NF-κB transactivation through phosphorylation of coactivator UXT.
    Chang LS, Wang JT, Doong SL, Lee CP, Chang CW, Tsai CH, Yeh SW, Hsieh CY, Chen MR., Free PMC Article

    01/12/2013
    Loss of ART-27 enhances expression of many androgen-regulated genes, suggesting that ART-27 inhibits gene expression, and nuclear ART-27 expression was lost in the majority of AR-positive recurrent prostate cancers.

    Genome-wide impact of androgen receptor trapped clone-27 loss on androgen-regulated transcription in prostate cancer cells.
    Nwachukwu JC, Mita P, Ruoff R, Ha S, Wang Q, Huang SJ, Taneja SS, Brown M, Gerald WL, Garabedian MJ, Logan SK., Free PMC Article

    09/10/2012
    UXT-V1 represents a novel integral component of the MAVS signalosome on mitochondria, mediating the innate antiviral signal transduction.

    UXT-V1 facilitates the formation of MAVS antiviral signalosome on mitochondria.
    Huang Y, Liu H, Ge R, Zhou Y, Lou X, Wang C.

    02/18/2012
    these results suggest that Als2 is a binding partner of Uxt and Als2/Uxt interaction could be important for the activation of Nf-kappaB pathway.

    Alfa-class prefoldin protein UXT is a novel interacting partner of Amyotrophic Lateral Sclerosis 2 (Als2) protein.
    Enunlu I, Ozansoy M, Basak AN.

    12/10/2011
    Data show that while Art-27 can bind AR directly, URI is bound to chromatin prior to hormone-dependent recruitment of AR, suggesting a role for URI in modulating AR recruitment to target genes.

    Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP.
    Mita P, Savas JN, Djouder N, Yates JR 3rd, Ha S, Ruoff R, Schafler ED, Nwachukwu JC, Tanese N, Cowan NJ, Zavadil J, Garabedian MJ, Logan SK., Free PMC Article

    10/15/2011
    Ubiquitously expressed transcript, UXT-V1, is a novel regulator of TNF-induced apoptosis. It protects cells against TNF-induced apoptosis through modulating complex II formation.

    UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.
    Huang Y, Chen L, Zhou Y, Liu H, Yang J, Liu Z, Wang C., Free PMC Article

    08/20/2011
    Is part of an RNA polymerase II-associated complex with possible chaperone activity.

    High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes.
    Cloutier P, Al-Khoury R, Lavallée-Adam M, Faubert D, Jiang H, Poitras C, Bouchard A, Forget D, Blanchette M, Coulombe B., Free PMC Article

    11/5/2009
    propose a transcriptional regulatory circuit for the developmental expression of ART-27 that includes repression by chromatin modification through a trichostatin A-sensitive factor and activation upon growth factor stimulation via CREB

    Transcriptional regulation of the androgen receptor cofactor androgen receptor trapped clone-27.
    Nwachukwu JC, Li W, Pineda-Torra I, Huang HY, Ruoff R, Shapiro E, Taneja SS, Logan SK, Garabedian MJ.

    01/21/2010
    Increasing concentrations of UXT contributes to progressive aggregation of mitochondria.

    UXT (Ubiquitously Expressed Transcript) causes mitochondrial aggregation.
    Moss TN, Vo A, McKeehan WL, Liu L., Free PMC Article

    01/21/2010
    UXT suppresses cell transformation and might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like ecotropic viral integration site 1

    UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation.
    McGilvray R, Walker M, Bartholomew C.

    01/21/2010
    decreased levels of ART-27 protein in prostate cancer tissue may occur as a result of de-differentiation, and indicate that ART-27 is likely to regulate a subset of AR-responsive genes important to prostate growth suppression and differentiation.

    ART-27, an androgen receptor coactivator regulated in prostate development and cancer.
    Taneja SS, Ha S, Swenson NK, Torra IP, Rome S, Walden PD, Huang HY, Shapiro E, Garabedian MJ, Logan SK.

    01/21/2010
    UXT is a component of centrosome and is essential for cell viability and may facilitate transformation by corrupting regulated centrosome functions.

    UXT is a novel centrosomal protein essential for cell viability.
    Zhao H, Wang Q, Zhang H, Liu Q, Du X, Richter M, Greene MI., Free PMC Article

    01/21/2010
    UXT is a novel and essential cofactor in the NF-kappa B transcriptional enhanceosome.

    UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome.
    Sun S, Tang Y, Lou X, Zhu L, Yang K, Zhang B, Shi H, Wang C., Free PMC Article

    01/21/2010
    UXT was identified in a screen for proteins that interact with the Androgen Receptor N-terminal activation domain. We termed the protein Androgen Receptor Trapped clone 27 (ART-27). ART-27 appears to function as a transcriptional coactivator protein.

    Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus.
    Markus SM, Taneja SS, Logan SK, Li W, Ha S, Hittelman AB, Rogatsky I, Garabedian MJ., Free PMC Article

    07/27/2002
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