| Promoter Methylation-mediated Silencing of the MiR-192-5p Promotes Endometrial Cancer Progression by Targeting ALX1. | Promoter Methylation-mediated Silencing of the MiR-192-5p Promotes Endometrial Cancer Progression by Targeting ALX1.
Ni J, Tian W, Liang S, Wang H, Ren Y., Free PMC Article | 12/11/2021 |
| ALX1 is highly expressed in human melanoma tissues and cell lines. Knockdown of ALX1 suppressed the proliferation and invasion of melanoma cells. | Knockdown of aristaless-like homeobox1 inhibits epithelial-mesenchymal transition through Wnt/β-catenin signaling pathway in melanoma cells.
Jiao JX, Jiao LJ, Yang S, Zhao YJ. | 12/14/2019 |
| According to our analysis, three proteins, namely aristaless-like homeobox1 isoform X1 (ALX1), major histocompatibility complex polypeptide-related sequence A (MICA), and uncharacterized protein C14orf105 isoform X12 were found to be potential markers for Opisthorchis viverrini (OV)- infection, as they were predominantly found in all OV-infected groups | Novel Potential Biomarkers for Opisthorchis viverrini Infection and Associated Cholangiocarcinoma.
Aksorn N, Roytrakul S, Kittisenachai S, Leelawat K, Chanvorachote P, Topanurak S, Hamano S, Lek-Uthai U., Free PMC Article | 10/13/2018 |
| Our study concludes that the splice site variant identified in the ALX1 gene causes mild form of Frontonasal dysplasia. | Exome sequencing revealed a novel splice site variant in the ALX1 gene underlying frontonasal dysplasia.
Ullah A, Kalsoom UE, Umair M, John P, Ansar M, Basit S, Ahmad W. | 07/1/2017 |
| we identify critical roles of ALX1 in lung cancer development and progression | ALX1 promotes migration and invasion of lung cancer cells through increasing snail expression.
Yao W, Liu Y, Zhang Z, Li G, Xu X, Zou K, Xu Y, Zou L., Free PMC Article | 10/22/2016 |
| Knockdown of the CART1 gene significantly inhibited cell invasion and proliferation and induce cell cycle arrest in S phase. | [Knockdown of CART1 induces S phase arrest and inhibits invasion and migration of MDA-MB-231 breast cancer cells].
Guan T, Su L, Yi Y. | 09/24/2016 |
| we found that depletion of ALX1 caused a dramatic cell cycle arrest, followed by massive apoptotic cell death, and eventually resulted in a significant decrease in migration and invasion of the osteosarcoma cell line studied. | Depletion of ALX1 causes inhibition of migration and induction of apoptosis in human osteosarcoma.
Yang M, Pan Y, Zhou Y. | 11/28/2015 |
| hypermethylation of HIST1H4F, PCDHGB6, NPBWR1, ALX1, and HOXA9 was significantly associated with shorter survival in stage 1 Non-small-cell lung cancer | A prognostic DNA methylation signature for stage I non-small-cell lung cancer.
Sandoval J, Mendez-Gonzalez J, Nadal E, Chen G, Carmona FJ, Sayols S, Moran S, Heyn H, Vizoso M, Gomez A, Sanchez-Cespedes M, Assenov Y, Müller F, Bock C, Taron M, Mora J, Muscarella LA, Liloglou T, Davies M, Pollan M, Pajares MJ, Torre W, Montuenga LM, Brambilla E, Field JK, Roz L, Lo Iacono M, Scagliotti GV, Rosell R, Beer DG, Esteller M. | 01/11/2014 |
| ALX1 upregulated expression of the key EMT regulator Snail (SNAI1) and that it mediated EMT activation and cell invasion by ALX1. | ALX1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of ovarian cancer cells.
Yuan H, Kajiyama H, Ito S, Yoshikawa N, Hyodo T, Asano E, Hasegawa H, Maeda M, Shibata K, Hamaguchi M, Kikkawa F, Senga T. | 04/27/2013 |
| Observational study of gene-disease association. (HuGE Navigator) | Genes encoding critical transcriptional activators for murine neural tube development and human spina bifida: a case-control study.
Lu W, Guzman AR, Yang W, Chapa CJ, Shaw GM, Greene RM, Pisano MM, Lammer EJ, Finnell RH, Zhu H., Free PMC Article | 12/5/2010 |
| Disruption of CART1 (ALX1) causes extreme microphthalmia and severe facial clefting. | Disruption of ALX1 causes extreme microphthalmia and severe facial clefting: expanding the spectrum of autosomal-recessive ALX-related frontonasal dysplasia.
Uz E, Alanay Y, Aktas D, Vargel I, Gucer S, Tuncbilek G, von Eggeling F, Yilmaz E, Deren O, Posorski N, Ozdag H, Liehr T, Balci S, Alikasifoglu M, Wollnik B, Akarsu NA., Free PMC Article | 06/28/2010 |