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    NAA60 N-alpha-acetyltransferase 60, NatF catalytic subunit [ Homo sapiens (human) ]

    Gene ID: 79903, updated on 17-Apr-2024

    GeneRIFs: Gene References Into Functions

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    GeneRIFPubMed TitleDate
    Biallelic NAA60 variants with impaired n-terminal acetylation capacity cause autosomal recessive primary familial brain calcifications.

    Biallelic NAA60 variants with impaired n-terminal acetylation capacity cause autosomal recessive primary familial brain calcifications.
    Chelban V, Aksnes H, Maroofian R, LaMonica LC, Seabra L, Siggervåg A, Devic P, Shamseldin HE, Vandrovcova J, Murphy D, Richard AC, Quenez O, Bonnevalle A, Zanetti MN, Kaiyrzhanov R, Salpietro V, Efthymiou S, Schottlaender LV, Morsy H, Scardamaglia A, Tariq A, Pagnamenta AT, Pennavaria A, Krogstad LS, Bekkelund ÅK, Caiella A, Glomnes N, Brønstad KM, Tury S, Moreno De Luca A, Boland-Auge A, Olaso R, Deleuze JF, Anheim M, Cretin B, Vona B, Alajlan F, Abdulwahab F, Battini JL, İpek R, Bauer P, Zifarelli G, Gungor S, Kurul SH, Lochmuller H, Da'as SI, Fakhro KA, Gómez-Pascual A, Botía JA, Wood NW, Horvath R, Ernst AM, Rothman JE, McEntagart M, Crow YJ, Alkuraya FS, Nicolas G, SYNaPS Study Group, Arnesen T, Houlden H., Free PMC Article

    		03/15/2024
    NAA60 (HAT4): the newly discovered bi-functional Golgi member of the acetyltransferase family.

    NAA60 (HAT4): the newly discovered bi-functional Golgi member of the acetyltransferase family.
    Donnarumma F, Tucci V, Ambrosino C, Altucci L, Carafa V., Free PMC Article

    		12/31/2022
    Results from a study on gene expression variability markers in early-stage human embryos shows that NAA60 (NAT15) is a putative expression variability marker for the 3-day, 8-cell embryo stage.

    Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
    Hasegawa Y, Taylor D, Ovchinnikov DA, Wolvetang EJ, de Torrenté L, Mar JC., Free PMC Article

    		07/23/2018
    The hNaa60 protein contains an amphipathic helix following its GNAT domain that may contribute to Golgi localization of hNaa60, and the beta7-beta8 hairpin adopted different conformations in the hNaa60(1-242) and hNaa60(1-199) crystal structures.

    Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase.
    Chen JY, Liu L, Cao CL, Li MJ, Tan K, Yang X, Yun CH., Free PMC Article

    		05/5/2018
    analysis of the mode of cytosolic Naa60 anchoring to the Golgi apparatus, most likely occurring post-translationally and specifically facilitating post-translational N-terminal acetylation of many transmembrane proteins

    Molecular determinants of the N-terminal acetyltransferase Naa60 anchoring to the Golgi membrane.
    Aksnes H, Goris M, Strømland Ø, Drazic A, Waheed Q, Reuter N, Arnesen T., Free PMC Article

    		06/24/2017
    Knockdown of the N-terminal acetyltransferase Naa60 compromises Golgi ribbon integrity.

    Holding it together: Naa60 at the Golgi.
    Aksnes H, Marie M, Arnesen T., Free PMC Article

    		11/25/2016
    The first crystal structure of the N-terminal acetyltransferase Naa60 reveals two elongated loops important for substrate-specific binding not found in other NAT structures.

    Crystal Structure of the Golgi-Associated Human Nα-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation.
    Støve SI, Magin RS, Foyn H, Haug BE, Marmorstein R, Arnesen T., Free PMC Article

    		11/25/2016
    Naa60 is necessary for maintenance of the Golgi ribbon through its Nt-acetylation of substrate protein(s) that is/are involved in Golgi ribbon structural and/or functional organization.

    An organellar nα-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity.
    Aksnes H, Van Damme P, Goris M, Starheim KK, Marie M, Støve SI, Hoel C, Kalvik TV, Hole K, Glomnes N, Furnes C, Ljostveit S, Ziegler M, Niere M, Gevaert K, Arnesen T.

    		11/28/2015
    Naa60 is an N-terminal acetyltransferase defined as NatF. Human and Drosophila melanogaster Naa60 acetylate Met-Lys- and other Met-starting N-termini. In Drosophila cells, NAA60 knockdown induced chromosomal segregation defects.

    NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation.
    Van Damme P, Hole K, Pimenta-Marques A, Helsens K, Vandekerckhove J, Martinho RG, Gevaert K, Arnesen T., Free PMC Article

    		11/12/2013
    HAT4 is an important player in the organization and function of the genome and may contribute to the diversity and complexity of higher eukaryotic organisms [HAT4]

    HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly.
    Yang X, Yu W, Shi L, Sun L, Liang J, Yi X, Li Q, Zhang Y, Yang F, Han X, Zhang D, Yang J, Yao Z, Shang Y.

    		09/14/2012
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