| Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis. | Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis.
Yu Z, Dong X, Song M, Xu A, He Q, Li H, Ouyang W, Chouchane L, Ma X., | 12/28/2023 |
| The clinicopathological and prognostic significances of CDC73 expression in breast cancer: A pathological and bioinformatics analysis. | The clinicopathological and prognostic significances of CDC73 expression in breast cancer: A pathological and bioinformatics analysis.
E Y, Xue H, Zhang CY, Zhao MZ, Zheng HC. | 04/4/2023 |
| Heterozygous CDC73 mutation causing hyperparathyroidism in children and adolescents: a report of 2 cases. | Heterozygous CDC73 mutation causing hyperparathyroidism in children and adolescents: a report of 2 cases.
Blackburn J, Mulvey I, Nadar R, Dias RP, Saraff V, Senniappan S. | 03/3/2023 |
| Para This, Fibromin That: The Role of CDC73 in Parathyroid Tumors and Familial Tumor Syndromes. | Para This, Fibromin That: The Role of CDC73 in Parathyroid Tumors and Familial Tumor Syndromes.
Ababneh E, Nosé V. | 02/11/2023 |
| A novel long-range deletion spanning CDC73 and upper-stream genes discovered in a kindred of familial primary hyperparathyroidism. | A novel long-range deletion spanning CDC73 and upper-stream genes discovered in a kindred of familial primary hyperparathyroidism.
Yang Y, Song A, Nie M, Jiang Y, Li M, Xia W, Xing X, Wang O, Hu Y. | 04/2/2022 |
| Cell-cell adhesion regulates Merlin/NF2 interaction with the PAF complex. | Cell-cell adhesion regulates Merlin/NF2 interaction with the PAF complex.
Roehrig AE, Klupsch K, Oses-Prieto JA, Chaib S, Henderson S, Emmett W, Young LC, Surinova S, Blees A, Pfeiffer A, Tijani M, Brunk F, Hartig N, Muñoz-Alegre M, Hergovich A, Jennings BH, Burlingame AL, Rodriguez-Viciana P., Free PMC Article | 11/27/2021 |
| The Oncosuppressors MEN1 and CDC73 Are Involved in lncRNA Deregulation in Human Parathyroid Tumors. | The Oncosuppressors MEN1 and CDC73 Are Involved in lncRNA Deregulation in Human Parathyroid Tumors.
Morotti A, Forno I, Verdelli C, Guarnieri V, Cetani F, Terrasi A, Silipigni R, Guerneri S, Andrè V, Scillitani A, Vicentini L, Ferrero S, Corbetta S, Vaira V. | 08/7/2021 |
| Tumor predisposition in an individual with chromosomal rearrangements of 1q31.2-q41 encompassing cell division cycle protein 73. | Tumor predisposition in an individual with chromosomal rearrangements of 1q31.2-q41 encompassing cell division cycle protein 73.
Nishimura N, Murakami H, Saito T, Masuno M, Kurosawa K. | 05/29/2021 |
| Loss of parafibromin expression was significantly higher in the parathyroid carcinoma than in the atypical parathyroid adenoma, parathyroid adenoma and parathyroid hyperplasia.[meta-analysis] | Diagnostic and prognostic implications of parafibromin immunohistochemistry in parathyroid carcinomaT.
Pyo JS, Cho WJ., Free PMC Article | 06/20/2020 |
| Parafibromin immunohistochemistry is a useful marker in the clinical routine when applied on a pre-selected material of cases, with positive immunoreactivity as a confident rule out marker of parathyroid malignancy. | Parafibromin immunostainings of parathyroid tumors in clinical routine: a near-decade experience from a tertiary center.
Juhlin CC, Nilsson IL, Lagerstedt-Robinson K, Stenman A, Bränström R, Tham E, Höög A. | 05/2/2020 |
| Our results suggest a novel pathway involving RNAPII, CDC73 and PNUTS-PP1 in ATR signaling and give new insight into the diverse functions of ATR. | Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1.
Landsverk HB, Sandquist LE, Sridhara SC, Rødland GE, Sabino JC, de Almeida SF, Grallert B, Trinkle-Mulcahy L, Syljuåsen RG., Free PMC Article | 08/24/2019 |
| our results provide a solid structural basis for understanding the structure and function of CDC73 and its association with the hyperparathyroidism-jaw tumor (HPT-JT) syndrome and other diseases | Crystal structure of the N-terminal domain of human CDC73 and its implications for the hyperparathyroidism-jaw tumor (HPT-JT) syndrome.
Sun W, Kuang XL, Liu YP, Tian LF, Yan XX, Xu W., Free PMC Article | 07/6/2019 |
| Three members of a family presented with mixed epithelial tumor of the kidney and were found to possess a germline mutation in CDC73, a gene which is associated with hyperparathyroidism-jaw tumor syndrome | CDC73 Germline Mutation in a Family With Mixed Epithelial and Stromal Tumors.
Vocke CD, Ricketts CJ, Ball MW, Schmidt LS, Metwalli AR, Middelton LA, Killian JK, Khan J, Meltzer PS, Simonds WF, Merino MJ, Linehan WM., Free PMC Article | 05/18/2019 |
| Somatic mutations in CDC73 were associated with sporadic parathyroid adenomas in a Chinese population. | Whole-Exome Sequencing Identifies Novel Recurrent Somatic Mutations in Sporadic Parathyroid Adenomas.
Wei Z, Sun B, Wang ZP, He JW, Fu WZ, Fan YB, Zhang ZL. | 03/2/2019 |
| post-transcriptional down-regulation of CDC73 contributed to cellular senescence. | Down-regulation of cancer-associated gene CDC73 contributes to cellular senescence.
Jia Q, Nie H, Wan X, Fu H, Yang F, Li Y, Wei G, Ni T. | 10/13/2018 |
| The HPT-JT syndrome - multiple Parathyroid Adenomas, Parathyroid Carcinomas in 15% of patients, as well as Fibro-osseous Jaw tumours (in 35% of patients) results from mutations of the CDC73 (HRPT2) gene (encoding parafibromin). | Introduction to symposium: 'New genetics with impact on treatment of endocrine tumour disease'.
| 07/14/2018 |
| CDC73 mutations are major driver mutations in the etiology of parathyroid carcinomas (PCs). | Molecular genetics of syndromic and non-syndromic forms of parathyroid carcinoma.
Cardoso L, Stevenson M, Thakker RV., Free PMC Article | 06/23/2018 |
| Each of these autosomal dominant syndromes results from a specific germline mutation in unique genes: MEN1 is due to pathogenic MEN1 variants (11q13), MEN2A and MEN2B are due to pathogenic RET variants (10q11.21), MEN4 is due to pathogenic CDKN1B variants (12p13.1), and the HPT-JT syndrome is due to pathogenic CDC73 variants (1q25). | Multiple Endocrine Neoplasia and Hyperparathyroid-Jaw Tumor Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.
Wasserman JD, Tomlinson GE, Druker H, Kamihara J, Kohlmann WK, Kratz CP, Nathanson KL, Pajtler KW, Parareda A, Rednam SP, States LJ, Villani A, Walsh MF, Zelley K, Schiffman JD., Free PMC Article | 05/5/2018 |
| Recurrent Hyperparathyroidism Due to a Novel CDC73 Splice Mutation. | Recurrent Hyperparathyroidism Due to a Novel CDC73 Splice Mutation.
Hattangady NG, Wilson TL, Miller BS, Lerario AM, Giordano TJ, Choksi P, Else T. | 04/28/2018 |
| Pathogenic germline CDC73 variants were identified in primary hyperparathyroidism patients, with (suspected) hyperparathyroidism-jaw tumor syndrome familial isolated primary hyperparathyroidism and apparently sporadic parathyroid carcinoma | CDC73-Related Disorders: Clinical Manifestations and Case Detection in Primary Hyperparathyroidism.
van der Tuin K, Tops CMJ, Adank MA, Cobben JM, Hamdy NAT, Jongmans MC, Menko FH, van Nesselrooij BPM, Netea-Maier RT, Oosterwijk JC, Valk GD, Wolffenbuttel BHR, Hes FJ, Morreau H. | 12/16/2017 |
| Data suggest that down-regulated parafibromin (HRPT2; CDC73) expression might be closely linked to colorectal carcinogenesis and cancer differentiation. | The in vitro and vivo effects of nuclear and cytosolic parafibromin expression on the aggressive phenotypes of colorectal cancer cells: a search of potential gene therapy target.
Zheng HC, Liu JJ, Li J, Wu JC, Yang L, Zhao GF, Zhao X, Jiang HM, Huang KQ, Li ZJ., Free PMC Article | 09/23/2017 |
| A novel deletion of exons 4 to 10 of CDC73 was detected by CNV analysis in the three affecteds. A novel insertion in the 5'UTR (c.-4_-11insG) that co-segregated with the deletion was identified. | Large intragenic deletion of CDC73 (exons 4-10) in a three-generation hyperparathyroidism-jaw tumor (HPT-JT) syndrome family.
Guarnieri V, Seaberg RM, Kelly C, Jean Davidson M, Raphael S, Shuen AY, Baorda F, Palumbo O, Scillitani A, Hendy GN, Cole DEC., Free PMC Article | 08/26/2017 |
| Germline mutation of HRPT2 is associated with parathyroid carcinoma. | A germline mutation of HRPT2/CDC73 (70 G>T) in an adolescent female with parathyroid carcinoma: first case report and a review of the literature.
Serrano-Gonzalez M, Shay S, Austin J, Maceri DR, Pitukcheewanont P. | 05/6/2017 |
| parafibromin downregulation might promote the pathogenesis, dedifferentiation and metastasis of ovarian cancers possibly by suppressing aggressive phenotypes, such as proliferation, cell cycle, apoptosis, migration and invasion. | The roles of parafibromin expression in ovarian epithelial carcinomas: a marker for differentiation and prognosis and a target for gene therapy.
Shen DF, Liu X, Yang XF, Fang L, Gao Y, Zhao S, Wu JC, Shi S, Li JJ, Zhao XX, Gou WF, Zheng HC. | 02/18/2017 |
| We suggest that parafibromin may be a possible prognostic and predictive parameter for breast carcinomas | The Relation of Parafibromin Expression with Clinicopathological Factors in Invasive Breast Carcinomas.
Karaarslan S, Genç B, Nart A, Börekçi İ, Buğdayci MH. | 01/28/2017 |