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    ZNF185 zinc finger protein 185 with LIM domain [ Homo sapiens (human) ]

    Gene ID: 7739, updated on 13-Feb-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    ZNF185 was mainly distributed in the cytoplasm of Leydig cells and Sertoli cells, as well as the head and tail of sperm cells.

    [Expression and localization of zinc finger protein 185 in sperm cells, Leydig cells and Sertoli cells of mouse testis].
    You X, Li H, Wei L, Fan S, Liu X, Chen L, Pan Z, Feng W.

    ZNF185 expression was significantly downregulated in lung adenocarcinoma tissues compared with the adjacent non-cancerous tissues and negatively correlated with lymphatic metastasis. ZNF185 overexpression inhibits the growth and invasion of LAC cells through inhibition of the AKT/GSK3beta signaling.

    ZNF185 inhibits growth and invasion of lung adenocarcinoma cells through inhibition of the akt/gsk3β pathway.
    Wang J, Huang HH, Liu FB.

    Transcriptional silencing of ZNF185 by methylation in prostate tumor tissues implicates the ZNF185 gene in prostate tumorigenesis.

    Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression.
    Vanaja DK, Cheville JC, Iturria SJ, Young CY.

    ZNF185 may function as a tumor-suppressor protein by associating with the actin-cytoskeleton

    ZNF185, an actin-cytoskeleton-associated growth inhibitory LIM protein in prostate cancer.
    Zhang JS, Gong A, Young CY.

    transcriptional activation of ZNF185 and CYP3A4 is mediated by direct association of BRG1 with their promoters and a decreased level of ZNF185 is a common feature of lung tumours

    Transcriptional targets of the chromatin-remodelling factor SMARCA4/BRG1 in lung cancer cells.
    Medina PP, Carretero J, Ballestar E, Angulo B, Lopez-Rios F, Esteller M, Sanchez-Cespedes M.

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