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    XRCC2 X-ray repair cross complementing 2 [ Homo sapiens (human) ]

    Gene ID: 7516, updated on 7-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Association between XRCC2 Arg188His Polymorphism and Breast Cancer Susceptibility: A Systematic Review and Meta-Analysis.

    Association between XRCC2 Arg188His Polymorphism and Breast Cancer Susceptibility: A Systematic Review and Meta-Analysis.
    Dastgheib SA, Sayad S, Azizi S, Hajizadeh N, Asadian F, Karimi-Zarchi M, Barahman M, Shiri A, Manzourolhojeh M, Aghili K, Neamatzadeh H., Free PMC Article

    02/16/2024
    Impact of Interaction between Single Nucleotide Polymorphism of XRCC1, XRCC2, XRCC3 with Tumor Suppressor Tp53 Gene Increases Risk of Breast Cancer: A Hospital Based Case-Control Study.

    Impact of Interaction between Single Nucleotide Polymorphism of XRCC1, XRCC2, XRCC3 with Tumor Suppressor Tp53 Gene Increases Risk of Breast Cancer: A Hospital Based Case-Control Study.
    Datkhile KD, Gudur RA, Bhosale SJ, Durgawale PP, Jagdale NJ, More AL, Gudur AK, Patil SR., Free PMC Article

    10/24/2023
    Association of RAD51, XRCC1, XRCC2, and XRCC3 Polymorphisms with Risk of Breast Cancer.

    Association of RAD51, XRCC1, XRCC2, and XRCC3 Polymorphisms with Risk of Breast Cancer.
    Gupta P, Sambyal V, Guleria K, Uppal MS, Sudan M.

    08/1/2023
    Structural insights into BCDX2 complex function in homologous recombination.

    Structural insights into BCDX2 complex function in homologous recombination.
    Rawal Y, Jia L, Meir A, Zhou S, Kaur H, Ruben EA, Kwon Y, Bernstein KA, Jasin M, Taylor AB, Burma S, Hromas R, Mazin AV, Zhao W, Zhou D, Wasmuth EV, Greene EC, Sung P, Olsen SK.,

    07/27/2023
    Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor.

    Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor.
    Greenhough LA, Liang CC, Belan O, Kunzelmann S, Maslen S, Rodrigo-Brenni MC, Anand R, Skehel M, Boulton SJ, West SC., Free PMC Article

    07/27/2023
    Overexpressed XRCC2 as an independent risk factor for poor prognosis in glioma patients.

    Overexpressed XRCC2 as an independent risk factor for poor prognosis in glioma patients.
    Liu Z, Zhang W, Cheng X, Wang H, Bian L, Wang J, Han Z, Wang Y, Lian X, Liu B, Ren Z, Zhang B, Jiang Z, Lin Z, Gao Y., Free PMC Article

    01/15/2022
    A Meta-Analysis for Association of XRCC1, XRCC2 and XRCC3 Polymorphisms with Susceptibility to Thyroid Cancer.

    A Meta-Analysis for Association of XRCC1, XRCC2 and XRCC3 Polymorphisms with Susceptibility to Thyroid Cancer.
    Mandegari M, Dastgheib SA, Asadian F, Shaker SH, Tabatabaie SM, Kargar S, Sadeghizadeh-Yazdi J, Neamatzadeh H., Free PMC Article

    01/1/2022
    Association of RAD51 and XRCC2 Gene Polymorphisms with Cervical Cancer Risk in the Bangladeshi Women.

    Association of RAD51 and XRCC2 Gene Polymorphisms with Cervical Cancer Risk in the Bangladeshi Women.
    Ivy SC, Shabnaz S, Shahriar M, Jafrin S, Aka TD, Aziz MA, Islam MS., Free PMC Article

    01/1/2022
    Association between RAD51, XRCC2 and XRCC3 gene polymorphisms and risk of ovarian cancer: a case control and an in silico study.

    Association between RAD51, XRCC2 and XRCC3 gene polymorphisms and risk of ovarian cancer: a case control and an in silico study.
    Gowtham Kumar G, Paul SFD, Martin J, Manickavasagam M, Sundersingh S, Ganesan N, Ramya R, Usha Rani G, Andrea Mary F.

    01/1/2022
    XRCC2 repairs mitochondrial DNA damage and fuels malignant behavior in hepatocellular carcinoma.

    XRCC2 repairs mitochondrial DNA damage and fuels malignant behavior in hepatocellular carcinoma.
    Zhao Z, He K, Zhang Y, Hua X, Feng M, Zhao Z, Sun Y, Jiang Y, Xia Q.

    11/22/2021
    A PRISMA-compliant meta-analysis on association between X-ray repair cross complementing (XRCC1, XRCC2, and XRCC3) polymorphisms and oral cancer susceptibility.

    A PRISMA-compliant meta-analysis on association between X-ray repair cross complementing (XRCC1, XRCC2, and XRCC3) polymorphisms and oral cancer susceptibility.
    Mozaffari HR, Rostamnia M, Sharifi R, Safaei M, Zavattaro E, Tadakamadla SK, Imani MM, Sadeghi M, Golshah A, Moradpoor H, Rezaei F, Omidpanah N, Hatami M.

    04/13/2021
    Genetic Variations of RAD51 and XRCC2 Genes Increase the Risk of Colorectal Cancer in Bangladeshi Population.

    Genetic Variations of RAD51 and XRCC2 Genes Increase the Risk of Colorectal Cancer in Bangladeshi Population.
    Hridy AU, Shabnaz S, Asaduzzaman MD, Shahriar M, Bhuiyan MA, Islam MS, Hossen SMM, Emran TB., Free PMC Article

    02/6/2021
    Association of XRCC2 rs2040639 with the survival of patients with oral squamous cell carcinoma undergoing concurrent chemoradiotherapy.

    Association of XRCC2 rs2040639 with the survival of patients with oral squamous cell carcinoma undergoing concurrent chemoradiotherapy.
    Senghore T, Wang WC, Chien HT, Chen YX, Young CK, Huang SF, Yeh CC.

    02/2/2021
    ERCC2 Lys751Gln rs13181 and XRCC2 Arg188His rs3218536 Gene Polymorphisms Contribute to Subsceptibility of Colon, Gastric, HCC, Lung And Prostate Cancer.

    ERCC2 Lys751Gln rs13181 and XRCC2 Arg188His rs3218536 Gene Polymorphisms Contribute to Subsceptibility of Colon, Gastric, HCC, Lung And Prostate Cancer.
    Balkan E, Bilici M, Gundogdu B, Aksungur N, Kara A, Yasar E, Dogan H, Ozturk G.

    12/12/2020
    XRCC2 mutation causes premature ovarian insufficiency as well as non-obstructive azoospermia in humans.

    XRCC2 mutation causes premature ovarian insufficiency as well as non-obstructive azoospermia in humans.
    Zhang YX, Li HY, He WB, Tu C, Du J, Li W, Lu GX, Lin G, Yang Y, Tan YQ.

    09/26/2020
    XRCC2 promoter and its utilization in the transcriptional targeting of cancer cells could achieve the major goals of cancer therapy: Although the way of virus-mediated delivery needs to be further improved, the feasibility of using viral vehicles containing XRCC2 promoter for cancer diagnosis and treatment in various types of tumors in vivo.

    Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy.
    Chen Y, Li Z, Xu Z, Tang H, Guo W, Sun X, Zhang W, Zhang J, Wan X, Jiang Y, Mao Z., Free PMC Article

    03/28/2020
    Truncating mutation of X-ray repair cross complementing 2 (XRCC2) c.96delT is a founder variant in Polish women with familial breast cancer. Breast cancers in XRCC2 mutation carriers and non-carriers are similar with respect to age of diagnosis and clinical characteristics. No cancer type is more common in first- or second-degree relatives of XRCC2 mutation carriers than in relatives of the non-carriers.

    Inherited variants in XRCC2 and the risk of breast cancer.
    Kluźniak W, Wokołorczyk D, Rusak B, Huzarski T, Gronwald J, Stempa K, Rudnicka H, Kashyap A, Dębniak T, Jakubowska A, Lener M, Szwiec M, Tomiczek-Szwiec J, Jarkiewicz-Tretyn J, Cechowska M, Domagała P, Szymiczek A, Bagherzadeh M, Lubiński J, Narod SA, Akbari MR, Cybulski C, Polish Hereditary Breast Cancer Consortium., Free PMC Article

    03/21/2020
    XRCC2 rs3218550C>T is a potential low-penetrant susceptibility allele for sporadic breast cancer.

    Electrophoretic mobility shift assays implicate XRCC2:rs3218550C>T as a potential low-penetrant susceptibility allele for sporadic breast cancer.
    Sirisena ND, Samaranayake N, Dissanayake VHW., Free PMC Article

    01/4/2020
    Women with GA and AA genotypes of DNA repair protein XRCC1+399A/G showed 2.4-3.8 fold higher risk of cervical cancer, however, DNA repair proteins XRCC2+31479G/A and XRCC3+18067C/T polymorphisms did not show any statistically significant associations.

    Genetic polymorphisms in DNA repair genes and their association with cervical cancer.
    Abbas M, Srivastava K, Imran M, Banerjee M.

    12/21/2019
    a subset of RAD51 paralogs, XRCC2 (FANCU) and its binding partner RAD51D, restrain active DNA synthesis during dinucleotide triphosphate (dNTP) alterations in a manner independent of homology-directed repair.

    XRCC2 Regulates Replication Fork Progression during dNTP Alterations.
    Saxena S, Somyajit K, Nagaraju G.

    12/7/2019
    XRCC2 mutation (c.41T>C/p.Leu14Pro) causes meiotic arrest, azoospermia and infertility but without other abnormalities in a consanguineous family.

    XRCC2 mutation causes meiotic arrest, azoospermia and infertility.
    Yang Y, Guo J, Dai L, Zhu Y, Hu H, Tan L, Chen W, Liang D, He J, Tu M, Wang K, Wu L., Free PMC Article

    10/19/2019
    A heterozygous frameshift mutation in the XRCC2 gene was identified in myelodysplastic syndrome patient. It leads to the formation of a truncated non-functional protein and decreased XRCC2 expression level. Decreased expression levels of all DNA repair genes functionally connected with mutated XRCC2 were also present.

    Genetic Variant Screening of DNA Repair Genes in Myelodysplastic Syndrome Identifies a Novel Mutation in the XRCC2 Gene.
    Valka J, Vesela J, Votavova H, Dostalova-Merkerova M, Urbanova Z, Jonasova A, Cermak J, Belickova M.

    09/14/2019
    The G allele of X-ray repair complementing defective repair in Chinese hamster cells 2 protein (XRCC2); AGC>AGG, p.Ser150Arg, may be a potential marker for colorectal cancer (CRC) in Iranians.

    Impact of a Missense Variation (p.S150R:AGC>AGG) in the XRCC2 Gene on Susceptibility to Colorectal Cancer.
    Sadat-Larijani M, Derakhshani S, Keshavarz-Pakseresht B, Nasri-Nasrabadi A, Shirkavand A, Sadat-Shandiz SA, Baghbani-Arani F.

    09/14/2019
    RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination

    RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination.
    Baldock RA, Pressimone CA, Baird JM, Khodakov A, Luong TT, Grundy MK, Smith CM, Karpenshif Y, Bratton-Palmer DS, Prakash R, Jasin M, Garcin EB, Gon S, Modesti M, Bernstein KA., Free PMC Article

    07/20/2019
    The results show that allele distributions and genotypes of XRCC2 SNPs are significantly associated with increased HNC risk and could be a genetic adjuster for the said disease.

    Haplotype analysis of XRCC2 gene polymorphisms and association with increased risk of head and neck cancer.
    Saeed S, Mahjabeen I, Sarwar R, Bashir K, Kayani MA., Free PMC Article

    07/6/2019
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