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    NR2C2 nuclear receptor subfamily 2 group C member 2 [ Homo sapiens (human) ]

    Gene ID: 7182, updated on 5-Mar-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Promotes clear cell renal carcinoma vasculogenic mimicry (VM) formation and its associated metastasis by modulating the miR490-3p-vimentin signals

    TR4 nuclear receptor promotes clear cell renal cell carcinoma (ccRCC) vasculogenic mimicry (VM) formation and metastasis via altering the miR490-3p/vimentin signals.
    Bai J, Yeh S, Qiu X, Hu L, Zeng J, Cai Y, Zuo L, Li G, Yang G, Chang C.

    The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1.

    The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1.
    Zhang B, Fu D, Xu Q, Cong X, Wu C, Zhong X, Ma Y, Lv Z, Chen F, Han L, Qian M, Chin YE, Lam EW, Chiao P, Sun Y., Free PMC Article

    Targeting the Cripto-1/TAK-1/NF-kappaB/Survivin pathway may be an effective approach to combat apoptosis resistance in cancer.

    Cripto-1 promotes resistance to drug-induced apoptosis by activating the TAK-1/NF-κB/survivin signaling pathway.
    Zhang Y, Mi X, Song Z, Li Y, YingShi, Niu J.

    blockage of RhoA/ROCK repressed the TAK1/NOD2-mediated NF-kappaB pathway in HaCaT cells exposed to UVB.

    Blocking RhoA/ROCK inhibits the pathogenesis of pemphigus vulgaris by suppressing oxidative stress and apoptosis through TAK1/NOD2-mediated NF-κB pathway.
    Liang J, Zeng X, Halifu Y, Chen W, Hu F, Wang P, Zhang H, Kang X.

    Study found that TR4 might be able to function through activation of the AKT3 expression to drive the EMT phenotype and enhance the seminoma cell proliferation and invasion.

    Testicular orphan receptor 4 promotes tumor progression and implies poor survival through AKT3 regulation in seminoma.
    Chen Y, Lu J, Xia L, Xue D, Yu X, Shen D, Xu L, Li G., Free PMC Article

    Altering TR4-ATF3 signaling increases the efficacy of cisplatin to suppress hepatocellular carcinoma growth/progression.

    TR4 nuclear receptor enhances the cisplatin chemo-sensitivity via altering the ATF3 expression to better suppress HCC cell growth.
    Shen J, Lin H, Li G, Jin RA, Shi L, Chen M, Chang C, Cai X., Free PMC Article

    High TAK1 expression is associated with the progression of hepatocellular carcinoma.

    The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma.
    Cao C, Zhang T, Zhang D, Xie L, Zou X, Lei L, Wu D, Liu L.

    Here, we report that Pseudomonas aeruginosa ExoY inhibits proinflammatory cytokine production through suppressing the activation of TAK1 as well as downstream NF-kappaB and mitogen-activated protein (MAP) kinases.

    Bacterial Nucleotidyl Cyclase Inhibits the Host Innate Immune Response by Suppressing TAK1 Activation.
    He C, Zhou Y, Liu F, Liu H, Tan H, Jin S, Wu W, Ge B., Free PMC Article

    SIRT7 inhibits TR4 degradation by deacetylation of DDB1.

    Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.
    Karim MF, Yoshizawa T, Sobuz SU, Sato Y, Yamagata K.

    TR4 binds GR to play an important role in glucocorticoid-directed corticotroph tumor POMC regulation in addition to modulating glucocorticoid actions on other GR targets.

    Testicular Receptor-4: Novel Regulator of Glucocorticoid Resistance.
    Zhang D, Du L, Heaney AP.

    this study shows that TAP1 plays a novel role in the negative regulation of virus-triggered NF-kappaB signaling and the innate immune response by targeting the TAK1 complex

    Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.
    Xia Z, Xu G, Yang X, Peng N, Zuo Q, Zhu S, Hao H, Liu S, Zhu Y.

    TAK1/TAB1 expression in non-small cell lung carcinoma tissue is significantly increased and closely associated with patient clinical prognosis.

    Expression of TAK1/TAB1 expression in non-small cell lung carcinoma and adjacent normal tissues and their clinical significance.
    Zhu J, Li Q, He JT, Liu GY., Free PMC Article

    miR-203 represses NF-kappaB signaling via targeting TAK1 and PI3KCA and miR-203 overexpression may contribute to the COPD initiation.

    Ectopic expressed miR-203 contributes to chronic obstructive pulmonary disease via targeting TAK1 and PIK3CA.
    Shi L, Xin Q, Chai R, Liu L, Ma Z., Free PMC Article

    DK1 inhibits the formation of the TAK1-TAB2-TRAF6 complex and leads to the inhibition of TRAF6 ubiquitination.

    Phosphoinositide-dependent kinase-1 inhibits TRAF6 ubiquitination by interrupting the formation of TAK1-TAB2 complex in TLR4 signaling.
    Moon G, Kim J, Min Y, Wi SM, Shim JH, Chun E, Lee KY.

    IFIT5 promotes SeV-induced IKK phosphorylation and NF-kappaB activation by regulating the recruitment of IKK to TAK1.

    IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1).
    Zheng C, Zheng Z, Zhang Z, Meng J, Liu Y, Ke X, Hu Q, Wang H.

    USP18 negatively regulates NF-kappaB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms.

    USP18 negatively regulates NF-κB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms.
    Yang Z, Xian H, Hu J, Tian S, Qin Y, Wang RF, Cui J., Free PMC Article

    Helicobacter pylori induces internalization of EGFR via novel TAK1-p38-serine activation pathway which is independent of HB-EGF.

    Helicobacter pylori Induces Serine Phosphorylation of EGFR via Novel TAK1-p38 Activation Pathway in an HB-EGF-Independent Manner.
    Zaidi SF, Refaat A, Zhou Y, Sualeh Muhammad J, Shin MS, Saiki I, Sakurai H, Sugiyama T.

    Together, these results demonstrate that LYTAK1 inhibits LPS-induced production of several pro-inflammatory cytokines and endotoxin shock probably through blocking TAK1-regulated signalings.

    LYATK1 potently inhibits LPS-mediated pro-inflammatory response.
    Xi F, Liu Y, Wang X, Kong W, Zhao F.

    TR4 expression in NSCLC samples is significantly associated with poor clinicopathological features, and TR4 plays an important role in the metastatic capacity of NSCLC cells by EMT regulation.

    Testicular orphan receptor 4 (TR4) is a marker for metastasis and poor prognosis in non-small cell lung cancer that drives the EMT phenotype.
    Zhang L, Zhang J, Ma Y, Chen J, Dong B, Zhao W, Wang X, Zheng Q, Fang F, Yang Y.

    TR4 may increase prostate cancer metastasis and invasion via decreasing the miR-373-3p expression that resulted in the activation of the TGFbetaR2/p-Smad3 signals.

    TR4 nuclear receptor increases prostate cancer invasion via decreasing the miR-373-3p expression to alter TGFβR2/p-Smad3 signals.
    Qiu X, Zhu J, Sun Y, Fan K, Yang DR, Li G, Yang G, Chang C., Free PMC Article

    TR4 was found to mediate the prostate cancer cells' radio-sensitivity.

    Testicular orphan nuclear receptor 4 is associated with the radio-sensitivity of prostate cancer.
    Yu S, Wang M, Ding X, Xia L, Chen B, Chen Y, Zhang Z, Niu Y, Li G, Chang C.

    Results suggest that the testicular nuclear receptor 4 (TR4) and oncogene EZH2 signaling may play a critical role in the prostate cancer stem/progenitor cell invasion.

    TR4 Nuclear Receptor Alters the Prostate Cancer CD133+ Stem/Progenitor Cell Invasion via Modulating the EZH2-Related Metastasis Gene Expression.
    Zhu J, Yang DR, Sun Y, Qiu X, Chang HC, Li G, Shan Y, Chang C., Free PMC Article

    IHC staining showed higher TR4 level, more macrophage infiltration, lower TIMP-1 and stronger MMP2/MMP9 in tumor tissues.

    Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating macrophages with alteration of the TIMP-1/MMP2/MMP9 signals.
    Ding X, Yang DR, Xia L, Chen B, Yu S, Niu Y, Wang M, Li G, Chang C., Free PMC Article

    PCa patients receiving TZD treatment who have one allele TR4 deletion.

    The Differential Effects of Anti-Diabetic Thiazolidinedione on Prostate Cancer Progression Are Linked to the TR4 Nuclear Receptor Expression Status.
    Lin SJ, Lin CY, Yang DR, Izumi K, Yan E, Niu X, Chang HC, Miyamoto H, Wang N, Li G, Chang C., Free PMC Article

    TAK1 activates NF-kappaB signaling activity such activated TAK1/NF-kappaB signaling cascade is indispensable in promoting ovarian cancer cell growth

    Elevated TAK1 augments tumor growth and metastatic capacities of ovarian cancer cells through activation of NF-κB signaling.
    Cai PC, Shi L, Liu VW, Tang HW, Liu IJ, Leung TH, Chan KK, Yam JW, Yao KM, Ngan HY, Chan DW., Free PMC Article

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