| DNA methylation profiling identifies epigenetic differences between early versus late stages of diabetic chronic kidney disease. | DNA methylation profiling identifies epigenetic differences between early versus late stages of diabetic chronic kidney disease.
Lecamwasam A, Novakovic B, Meyer B, Ekinci EI, Dwyer KM, Saffery R. | 01/22/2022 |
| CRISP2, CATSPER1 and PATE1 Expression in Human Asthenozoospermic Semen. | CRISP2, CATSPER1 and PATE1 Expression in Human Asthenozoospermic Semen.
Manfrevola F, Ferraro B, Sellitto C, Rocco D, Fasano S, Pierantoni R, Chianese R., Free PMC Article | 11/22/2021 |
| Discovery and validation of novel biomarkers for detection of cervical cancer. | Discovery and validation of novel biomarkers for detection of cervical cancer.
Li Z, Chen J, Zhao S, Li Y, Zhou J, Liang J, Tang H., Free PMC Article | 07/24/2021 |
| The integrated network analysis identified BRCA1 and CRISP2 differentially methylated regions (DMR) as the most central disease-associated DNA methylation biomarkers. Moreover, methylation changes at BRCA1 and CRISP2 specific CpG sites were consistently associated with subclinical atherosclerosis measures. | Identification of differentially methylated BRCA1 and CRISP2 DNA regions as blood surrogate markers for cardiovascular disease.
Istas G, Declerck K, Pudenz M, Szic KSV, Lendinez-Tortajada V, Leon-Latre M, Heyninck K, Haegeman G, Casasnovas JA, Tellez-Plaza M, Gerhauser C, Heiss C, Rodriguez-Mateos A, Berghe WV., Free PMC Article | 02/2/2019 |
| low expression of CRISP2 protein rather than its mRNA was observed in the ejaculated spermatozoa from asthenoteratozoospermic patients as compared with normozoospermic males | MicroRNA-27a-mediated repression of cysteine-rich secretory protein 2 translation in asthenoteratozoospermic patients.
Zhou JH, Zhou QZ, Yang JK, Lyu XM, Bian J, Guo WB, Chen ZJ, Xia M, Xia H, Qi T, Li X, Liu CD., Free PMC Article | 05/5/2018 |
| Results identified CRISP2 as a potential binding protein of PSP94 from human sperm. | Identification of CRISP2 from human sperm as PSP94-binding protein and generation of CRISP2-specific anti-peptide antibodies.
Anklesaria JH, Kulkarni BJ, Pathak BR, Mahale SD. | 03/4/2017 |
| Crisp2 genetic defects in sperm from humans and mice result in male infertility. | Fertilization defects in sperm from Cysteine-rich secretory protein 2 (Crisp2) knockout mice: implications for fertility disorders.
Brukman NG, Miyata H, Torres P, Lombardo D, Caramelo JJ, Ikawa M, Da Ros VG, Cuasnicú PS. | 12/17/2016 |
| Preliminary insight into the mechanism leading to the reduced CRISP2 expression in asthenozoospermia, offering a potential therapeutic target for treating male infertility or for male contraception. | The expression of cysteine-rich secretory protein 2 (CRISP2) and its specific regulator miR-27b in the spermatozoa of patients with asthenozoospermia.
Zhou JH, Zhou QZ, Lyu XM, Zhu T, Chen ZJ, Chen MK, Xia H, Wang CY, Qi T, Li X, Liu CD. | 09/12/2015 |
| Study shows the re-association of sperm acrosomal CRISP2 at the EqS during the acrosome reaction. Data showed that F-actin is not involved in the relocalization of CRISP2. Found that basic,but not acidic, conditions can solubilize CRISP2 from sperm cells. | Human sperm CRISP2 is released from the acrosome during the acrosome reaction and re-associates at the equatorial segment.
Nimlamool W, Bean BS, Lowe-Krentz LJ. | 01/18/2014 |
| CRISP2 rescues the phenotype of yeast mutants lacking Pry function and purified CRISP2 binds cholesterol in vitro, indicating that lipid binding is a conserved function of the CAP superfamily proteins. | Pathogen-Related Yeast (PRY) proteins and members of the CAP superfamily are secreted sterol-binding proteins.
Choudhary V, Schneiter R., Free PMC Article | 01/5/2013 |
| The down-regulation of CRISP2 mRNA and protein expressions in the sperm of asthenospermia patients may be closely related with decreased sperm motility. | [Expressions of cysteine-rich secretory protein 2 in asthenospermia].
Jing XW, Xing RW, Zhou QZ, Yu QF, Guo WB, Chen SM, Chu QJ, Feng CQ, Mao XM. | 11/19/2011 |
| Additional transcription changes likely associated with Th2-like eosinophilic inflammation were prominent and included decreased CRISP2&3. | Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis.
Plager DA, Kahl JC, Asmann YW, Nilson AE, Pallanch JF, Friedman O, Kita H., Free PMC Article | 10/30/2010 |
| Polymorphisms within the CRISP2 gene have no significant association with male infertility. | Polymorphisms in the human cysteine-rich secretory protein 2 (CRISP2) gene in Australian men.
Jamsai D, Reilly A, Smith SJ, Gibbs GM, Baker HW, McLachlan RI, de Kretser DM, O'Bryan MK, Jamsai D, Reilly A, Smith SJ, Gibbs GM, Baker HW, McLachlan RI, de Kretser DM, O'Bryan MK. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Polymorphisms in the human cysteine-rich secretory protein 2 (CRISP2) gene in Australian men.
Jamsai D, Reilly A, Smith SJ, Gibbs GM, Baker HW, McLachlan RI, de Kretser DM, O'Bryan MK, Jamsai D, Reilly A, Smith SJ, Gibbs GM, Baker HW, McLachlan RI, de Kretser DM, O'Bryan MK. | 06/29/2008 |
| The protein level and localization of TPX1 were altered in patients with spermatogenic arrest and in infertile men with oligoasthenoteratospermia syndrome. | Human testis specific protein 1 expression in human spermatogenesis and involvement in the pathogenesis of male infertility.
Du Y, Huang X, Li J, Hu Y, Zhou Z, Sha J. | 01/21/2010 |
| TPX1 is a component of the sperm acrosome that remains associated with sperm after capacitation and acrosome reaction , and is relevant for sperm-oocyte interaction. | Human testicular protein TPX1/CRISP-2: localization in spermatozoa, fate after capacitation and relevance for gamete interaction.
Busso D, Cohen DJ, Hayashi M, Kasahara M, Cuasnicú PS. | 01/21/2010 |