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    TSPAN7 tetraspanin 7 [ Homo sapiens (human) ]

    Gene ID: 7102, updated on 21-Apr-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    These results disclosed a previously uncharacterized role of TSPAN7 in the regulation of the expression and functional activity of DRD2 by postendocytic trafficking.

    Functional expression of dopamine D2 receptor is regulated by tetraspanin 7-mediated postendocytic trafficking.
    Lee SA, Suh Y, Lee S, Jeong J, Kim SJ, Kim SJ, Park SK.

    09/16/2017
    The role of TSPAN7 in immune system response to HIV-1 is reviewed. TSPAN7 appears to be a positive regulator of actin nucleation and stabilization, through the ARP2/3 complex. By doing so, TSPAN7 limits HIV-1 endocytosis and maintains viral particles on actin-rich dendrites for an efficient transfer toward T lymphocytes.

    TSPAN7, effector of actin nucleation required for dendritic cell-mediated transfer of HIV-1 to T cells.
    Ménager MM.

    08/12/2017
    Elevated TSPAN7 may be associated with better outcomes for multiple myeloma patients.

    Tetraspanin 7 (TSPAN7) expression is upregulated in multiple myeloma patients and inhibits myeloma tumour development in vivo.
    Cheong CM, Chow AW, Fitter S, Hewett DR, Martin SK, Williams SA, To LB, Zannettino AC, Vandyke K.

    04/25/2015
    Loss of TSPAN7 is associated with metastasis in clear-cell renal cell carcinoma.

    CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases.
    Wuttig D, Zastrow S, Füssel S, Toma MI, Meinhardt M, Kalman K, Junker K, Sanjmyatav J, Boll K, Hackermüller J, Rolle A, Grimm MO, Wirth MP.

    09/22/2012
    This study identified that TSPAN7 as a key molecule for the functional maturation of dendritic spines via PICK1 and ampa receptor trafficking.

    The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking.
    Bassani S, Cingolani LA, Valnegri P, Folci A, Zapata J, Gianfelice A, Sala C, Goda Y, Passafaro M., Free PMC Article

    05/19/2012
    TM4SF2 was identified as a putative antigenic target in Wegener's granulomatosis

    Wegener's granuloma harbors B lymphocytes with specificities against a proinflammatory transmembrane protein and a tetraspanin.
    Thurner L, Müller A, Cérutti M, Martin T, Pasquali JL, Gross WL, Preuss KD, Pfreundschuh M, Voswinkel J.

    04/30/2011
    Studies indicate that The thymus leukemia (TL) antigen and CD8alphaalpha are interacting surface molecules that are expressed at the frontline of the mucosal immune system.

    TL and CD8αα: Enigmatic partners in mucosal immunity.
    Olivares-Villagómez D, Van Kaer L., Free PMC Article

    03/5/2011
    The interaction of VP26 with tetraspanin-7 plays an essential role in normal HSV-1 replication.

    Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein.
    Wang L, Liu L, Che Y, Wang L, Jiang L, Dong C, Zhang Y, Li Q., Free PMC Article

    09/13/2010
    associated with spermatozoa

    Novel partners of SPAG11B isoform D in the human male reproductive tract.
    Radhakrishnan Y, Hamil KG, Tan JA, Grossman G, Petrusz P, Hall SH, French FS., Free PMC Article

    01/21/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia.
    Piton A, Gauthier J, Hamdan FF, Lafrenière RG, Yang Y, Henrion E, Laurent S, Noreau A, Thibodeau P, Karemera L, Spiegelman D, Kuku F, Duguay J, Destroismaisons L, Jolivet P, Côté M, Lachapelle K, Diallo O, Raymond A, Marineau C, Champagne N, Xiong L, Gaspar C, Rivière JB, Tarabeux J, Cossette P, Krebs MO, Rapoport JL, Addington A, Delisi LE, Mottron L, Joober R, Fombonne E, Drapeau P, Rouleau GA.

    Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.
    Guilmatre A, Dubourg C, Mosca AL, Legallic S, Goldenberg A, Drouin-Garraud V, Layet V, Rosier A, Briault S, Bonnet-Brilhault F, Laumonnier F, Odent S, Le Vacon G, Joly-Helas G, David V, Bendavid C, Pinoit JM, Henry C, Impallomeni C, Germano E, Tortorella G, Di Rosa G, Barthelemy C, Andres C, Faivre L, Frébourg T, Saugier Veber P, Campion D.

    09/20/2009
    coding mutations in TSPAN7 are not associated with our cohort of autism patients

    Copy number variation analysis and sequencing of the X-linked mental retardation gene TSPAN7/TM4SF2 in patients with autism spectrum disorder.
    Noor A, Gianakopoulos PJ, Fernandez B, Marshall CR, Szatmari P, Roberts W, Scherer SW, Vincent JB.

    01/21/2010
    The role of TMSF2 in mental retardation

    Does the P172H mutation at the TM4SF2 gene cause X-linked mental retardation?
    Maranduba CM, Sá Moreira E, Müller Orabona G, Pavanello RC, Vianna-Morgante AM, Passos-Bueno MR.

    01/21/2010
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