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    TEC tec protein tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 7006, updated on 17-Jun-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    TEC is yet another regulator of FGF2-mediated Human pluripotent stem cells pluripotency and differentiation.

    Tyrosine Kinase Expressed in Hepatocellular Carcinoma, TEC, Controls Pluripotency and Early Cell Fate Decisions of Human Pluripotent Stem Cells via Regulation of Fibroblast Growth Factor-2 Secretion.
    Vanova T, Konecna Z, Zbonakova Z, La Venuta G, Zoufalova K, Jelinkova S, Varecha M, Rotrekl V, Krejci P, Nickel W, Dvorak P, Kunova Bosakova M.

    High TEC expression is associated with the development of Mallory Denk Bodies in balloon cells in alcoholic hepatitis.

    The role of Tec kinase signaling pathways in the development of Mallory Denk Bodies in balloon cells in alcoholic hepatitis.
    Afifiyan N, Tillman B, French BA, Sweeny O, Masouminia M, Samadzadeh S, French SW., Free PMC Article

    using RNA interference, the identified compounds corroborate the role of Tec kinase in unconventional secretion of FGF2.

    Small Molecule Inhibitors Targeting Tec Kinase Block Unconventional Secretion of Fibroblast Growth Factor 2.
    La Venuta G, Wegehingel S, Sehr P, Müller HM, Dimou E, Steringer JP, Grotwinkel M, Hentze N, Mayer MP, Will DW, Uhrig U, Lewis JD, Nickel W., Free PMC Article

    These results provide the first evidence that Nef interacts with cytoplasmic tyrosine kinases of the Tec family and suggest that Nef provides a mechanistic link between HIV-1 and Itk signaling in the viral life cycle.

    The accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner.
    Tarafdar S, Poe JA, Smithgall TE., Free PMC Article

    results suggest that the oncogenic effect of the t(3;9) translocation may be due to the TFG-TEC chimeric protein and that fusion of the TFG (NTD) to the TEC protein produces a gain-of-function chimeric product

    The TFG-TEC fusion gene created by the t(3;9) translocation in human extraskeletal myxoid chondrosarcomas encodes a more potent transcriptional activator than TEC.
    Lim B, Jun HJ, Kim AY, Kim S, Choi J, Kim J.

    Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

    Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators.., Free PMC Article

    Overexpression of Tec is associated with the tumorigenesis and development of liver cancer.

    [The expression of Tec and the level of its phosphorylation in primary hepatic carcinomas].
    Chen C, Wang G, Zhang ZM, Xu W, Li Q, Hu Q, Wang D, Li ZP, Yang ZX, Suo JY, Zheng JJ, Wang HZ.

    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    Tec kinase has a crucial role in regulating FGF2 secretion under various physiological conditions

    Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion.
    Ebert AD, Laussmann M, Wegehingel S, Kaderali L, Erfle H, Reichert J, Lechner J, Beer HD, Pepperkok R, Nickel W.

    inhibits CD25 expression in human T-lymphocytes

    Tec protein tyrosine kinase inhibits CD25 expression in human T-lymphocyte.
    Susaki K, Kitanaka A, Dobashi H, Kubota Y, Kittaka K, Kameda T, Yamaoka G, Mano H, Mihara K, Ishida T.

    LPS-induced actin polymerization as well as MCP-1, tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta expression are dependent on Tec kinase activity.

    Tec kinases regulate actin assembly and cytokine expression in LPS-stimulated human neutrophils via JNK activation.
    Zemans RL, Arndt PG., Free PMC Article

    Tec is the principal kinase of the Tec family that plays a major role in the responses of human neutrophils to monosodium urate crystals, which are likely to be involved in the initiation and perpetuation of gout

    Crystal-induced neutrophil activation: X. Proinflammatory role of the tyrosine kinase Tec.
    Popa-Nita O, Marois L, Paré G, Naccache PH.

    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators., NORDIL investigators., BRIGHT Consortium..

    Candidate gene analysis in primary lymphedema.
    Ferrell RE, Kimak MA, Lawrence EC, Finegold DN.

    specificity in tyrosine phosphorylation of SH3 domains in vitro is high and, therefore, SH3 domain phosphorylation is required for a distinct function in signaling

    Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.
    Nore BF, Mattsson PT, Antonsson P, Bäckesjö CM, Westlund A, Lennartsson J, Hansson H, Löw P, Rönnstrand L, Smith CI.

    The AF2 domain of the orphan nuclear receptor is essential for the transcriptional activity of the oncogenic fusion protein EWS

    The AF2 domain of the orphan nuclear receptor TEC is essential for the transcriptional activity of the oncogenic fusion protein EWS/TEC.
    Maltais A, Filion C, Labelle Y.

    Tec overexpression in lymphocyte cell lines is sufficient to induce phospholipase Cgamma (PLC-gamma) phosphorylation and NFAT (nuclear factor of activated T cells) activation.

    Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec.
    Tomlinson MG, Kane LP, Su J, Kadlecek TA, Mollenauer MN, Weiss A., Free PMC Article

    Btk/Tec kinases control sustained calcium signaling via site-specific phosphorylation of key residues within the phospholipase C gamma2 SH2-SH3 linker

    Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker.
    Humphries LA, Dangelmaier C, Sommer K, Kipp K, Kato RM, Griffith N, Bakman I, Turk CW, Daniel JL, Rawlings DJ.

    SHIP1 and SHIP2 interact preferentially with Tec and inactivate it by de-phosphorylation of local PtdIns 3,4,5-P(3) and inhibition of Tec membrane localization

    SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase.
    Tomlinson MG, Heath VL, Turck CW, Watson SP, Weiss A.

    Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils

    Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. Implication of phosphatidynositol 3-kinases.
    Lachance G, Levasseur S, Naccache PH.

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