| Arterial cyclic stretch regulates Lamtor1 and promotes neointimal hyperplasia via circSlc8a1/miR-20a-5p axis in vein grafts. | Arterial cyclic stretch regulates Lamtor1 and promotes neointimal hyperplasia via circSlc8a1/miR-20a-5p axis in vein grafts.
Liu JT, Yao QP, Chen Y, Lv F, Liu Z, Bao H, Han Y, Zhang ML, Jiang ZL, Qi YX., Free PMC Article | 07/23/2022 |
| LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function. | LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function.
Sun J, Liu Y, Hao X, Lin W, Su W, Chiang E, Baudry M, Bi X., Free PMC Article | 03/12/2022 |
| p18/Lamtor1-mTORC1 Signaling Controls Development of Mucin-producing Goblet Cells in the Intestine. | p18/Lamtor1-mTORC1 Signaling Controls Development of Mucin-producing Goblet Cells in the Intestine.
Ito S, Nada S, Yamazaki D, Kimura T, Kajiwara K, Miki H, Okada M., Free PMC Article | 09/4/2021 |
| Loss of LAMTOR1 in pancreatic betacells increases glucosestimulated insulin secretion in mice. | Loss of LAMTOR1 in pancreatic β‑cells increases glucose‑stimulated insulin secretion in mice.
Huang Q, Gong Q, Wen T, Feng S, Xu J, Liu J, Han X, Liu Q, Hu J, Zhu L., Free PMC Article | 10/10/2020 |
| The amino acid-sensing pathway consisting of Lamtor1, mTORC1, and TFEB is involved in the regulation of innate immune responses. | Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB.
Hayama Y, Kimura T, Takeda Y, Nada S, Koyama S, Takamatsu H, Kang S, Ito D, Maeda Y, Nishide M, Nojima S, Sarashina-Kida H, Hosokawa T, Kinehara Y, Kato Y, Nakatani T, Nakanishi Y, Tsuda T, Koba T, Okada M, Kumanogoh A. | 04/13/2019 |
| Here the authors report that Ube3a regulates mTORC1 signaling by targeting p18, a subunit of the Ragulator. Ube3a ubiquitinates p18, resulting in its proteasomal degradation. | UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity.
Sun J, Liu Y, Jia Y, Hao X, Lin WJ, Tran J, Lynch G, Baudry M, Bi X., Free PMC Article | 03/16/2019 |
| Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals. | Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals.
Kimura T, Nada S, Takegahara N, Okuno T, Nojima S, Kang S, Ito D, Morimoto K, Hosokawa T, Hayama Y, Mitsui Y, Sakurai N, Sarashina-Kida H, Nishide M, Maeda Y, Takamatsu H, Okuzaki D, Yamada M, Okada M, Kumanogoh A., Free PMC Article | 08/25/2018 |
| both the mRNA and protein levels of LAMTOR1 increase progressively in cleavage-stage mouse embryos. LAMTOR1 has a signi fi cant higher embryonic expression at 2-cell to morula stage. LAMTOR1 may play a role in the oogenesis process and probably required for further developmental stages and it may play a possible role in the process of compaction and cavitation in mice. | Investigation of LAMTOR1 gene and protein expressions in germinal vesicle and metaphase II oocytes and embryos from 1-cell to blastocyst stage in a mouse model.
Gumus E, Sari I, Yilmaz M, Cetin A. | 08/4/2018 |
| this study shows that polarization of Th17 cells, but not Th1 and Th2 cells, diminishes following the loss of Lamtor1; Lamtor1-knockout mice are resistant to experimental autoimmune encephalomyelitis | Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function.
Hosokawa T, Kimura T, Nada S, Okuno T, Ito D, Kang S, Nojima S, Yamashita K, Nakatani T, Hayama Y, Kato Y, Kinehara Y, Nishide M, Mikami N, Koyama S, Takamatsu H, Okuzaki D, Ohkura N, Sakaguchi S, Okada M, Kumanogoh A. | 10/14/2017 |
| Data suggest that ablation of p18/LAMTOR1 suppresses starvation-induced cell death by stimulating autophagy through modulation of p27(kip1) activity. | Depletion of p18/LAMTOR1 promotes cell survival via activation of p27(kip1) -dependent autophagy under starvation.
Zada S, Noh HS, Baek SM, Ha JH, Hahm JR, Kim DR. | 08/20/2016 |
| Findings suggested that the p18-associated pathways, mTORC1 and/or MAPK pathways, are involved in promoting functional interactions between lysosomes and target organelles to regulate lysosome-mediated catabolic processes. | The lysosomal signaling anchor p18/LAMTOR1 controls epidermal development by regulating lysosome-mediated catabolic processes.
Soma-Nagae T, Nada S, Kitagawa M, Takahashi Y, Mori S, Oneyama C, Okada M. | 06/21/2014 |
| These results suggest that the p18-mTORC1 pathway plays crucial roles in the late stages of lysosomal maturation, potentially in late endosome-lysosome fusion, which is required for processing of various macromolecules. | The late endosome/lysosome-anchored p18-mTORC1 pathway controls terminal maturation of lysosomes.
Takahashi Y, Nada S, Mori S, Soma-Nagae T, Oneyama C, Okada M. | 04/7/2012 |
| analysis of interactions between kinase scaffold MP1/p14 and its endosomal anchoring protein p18 | Interactions between kinase scaffold MP1/p14 and its endosomal anchoring protein p18.
Magee J, Cygler M. | 07/16/2011 |
| A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC. | A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC.
Hoshino D, Koshikawa N, Seiki M., Free PMC Article | 03/5/2011 |
| lipid raft adaptor p18 is essential for anchoring the MEK-ERK pathway to late endosomes, and shed new light on a role of endosomal MEK-ERK pathway in controlling endosome dynamics. | The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.
Nada S, Hondo A, Kasai A, Koike M, Saito K, Uchiyama Y, Okada M., Free PMC Article | 01/21/2010 |