| CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension. | CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension.
Wang H, Ma T, Zhang X, Chen W, Lan Y, Kuang G, Hsu SJ, He Z, Chen Y, Stewart J, Bhattacharjee A, Luo Z, Price C, Feng X., Free PMC Article | 07/13/2023 |
| Complex interaction network revealed by mutation of human telomerase 'insertion in fingers' and essential N-terminal domains and the telomere protein TPP1. | Complex interaction network revealed by mutation of human telomerase 'insertion in fingers' and essential N-terminal domains and the telomere protein TPP1.
Lambert-Lanteigne P, Young A, Autexier C., Free PMC Article | 04/5/2023 |
| TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma. | TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma.
Chun-On P, Hinchie AM, Beale HC, Gil Silva AA, Rush E, Sander C, Connelly CJ, Seynnaeve BKN, Kirkwood JM, Vaske OM, Greider CW, Alder JK., Free PMC Article | 11/19/2022 |
| Coordinated interactions of multiple POT1-TPP1 proteins with telomere DNA. | Coordinated interactions of multiple POT1-TPP1 proteins with telomere DNA.
Corriveau M, Mullins MR, Baus D, Harris ME, Taylor DJ., Free PMC Article | 10/22/2022 |
| Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells. | Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells.
Grill S, Bisht K, Tesmer VM, Shami AN, Hammoud SS, Nandakumar J., Free PMC Article | 10/22/2022 |
| Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance. | Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance.
Rajavel M, Orban T, Xu M, Hernandez-Sanchez W, de la Fuente M, Palczewski K, Taylor DJ., Free PMC Article | 10/22/2022 |
| NEK6-mediated phosphorylation of human TPP1 regulates telomere length through telomerase recruitment. | NEK6-mediated phosphorylation of human TPP1 regulates telomere length through telomerase recruitment.
Hirai Y, Tamura M, Otani J, Ishikawa F. | 10/22/2022 |
| Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1. | Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1.
Kocak H, Ballew BJ, Bisht K, Eggebeen R, Hicks BD, Suman S, O'Neil A, Giri N, NCI DCEG Cancer Genomics Research Laboratory, NCI DCEG Cancer Sequencing Working Group, Maillard I, Alter BP, Keegan CE, Nandakumar J, Savage SA., Free PMC Article | 10/22/2022 |
| G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding. | G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding.
Ray S, Bandaria JN, Qureshi MH, Yildiz A, Balci H., Free PMC Article | 10/22/2022 |
| Suppression of telomere-binding protein TPP1 resulted in telomere dysfunction and enhanced radiation sensitivity in telomerase-negative osteosarcoma cell line. | Suppression of telomere-binding protein TPP1 resulted in telomere dysfunction and enhanced radiation sensitivity in telomerase-negative osteosarcoma cell line.
Qiang W, Wu Q, Zhou F, Xie C, Wu C, Zhou Y. | 10/22/2022 |
| The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7. | The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7.
Zemp I, Lingner J., Free PMC Article | 10/22/2022 |
| Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease. | Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease.
Ahmad T, Sundar IK, Tormos AM, Lerner CA, Gerloff J, Yao H, Rahman I., Free PMC Article | 10/22/2022 |
| Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment. | Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment.
Zhang Y, Chen LY, Han X, Xie W, Kim H, Yang D, Liu D, Songyang Z., Free PMC Article | 10/22/2022 |
| POT1-TPP1 regulates telomeric overhang structural dynamics. | POT1-TPP1 regulates telomeric overhang structural dynamics.
Hwang H, Buncher N, Opresko PL, Myong S., Free PMC Article | 10/22/2022 |
| POT1-TPP1 Binding and Unfolding of Telomere DNA Discriminates against Structural Polymorphism. | POT1-TPP1 Binding and Unfolding of Telomere DNA Discriminates against Structural Polymorphism.
Mullins MR, Rajavel M, Hernandez-Sanchez W, de la Fuente M, Biendarra SM, Harris ME, Taylor DJ., Free PMC Article | 10/22/2022 |
| The Insertion in Fingers Domain in Human Telomerase Can Mediate Enzyme Processivity and Telomerase Recruitment to Telomeres in a TPP1-Dependent Manner. | The Insertion in Fingers Domain in Human Telomerase Can Mediate Enzyme Processivity and Telomerase Recruitment to Telomeres in a TPP1-Dependent Manner.
Chu TW, D'Souza Y, Autexier C., Free PMC Article | 10/22/2022 |
| Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis. | Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis.
Liu J, Yu C, Hu X, Kim JK, Bierma JC, Jun HI, Rychnovsky SD, Huang L, Qiao F., Free PMC Article | 10/22/2022 |
| Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation. | Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation.
Sexton AN, Regalado SG, Lai CS, Cost GJ, O'Neil CM, Urnov FD, Gregory PD, Jaenisch R, Collins K, Hockemeyer D., Free PMC Article | 10/22/2022 |
| Telomere-binding protein TPP1 modulates telomere homeostasis and confers radioresistance to human colorectal cancer cells. | Telomere-binding protein TPP1 modulates telomere homeostasis and confers radioresistance to human colorectal cancer cells.
Yang L, Wang W, Hu L, Yang X, Zhong J, Li Z, Yang H, Lei H, Yu H, Liao Z, Zhou F, Xie C, Zhou Y., Free PMC Article | 10/22/2022 |
| Akt regulates TPP1 homodimerization and telomere protection. | Akt regulates TPP1 homodimerization and telomere protection.
Han X, Liu D, Zhang Y, Li Y, Lu W, Chen J, Songyang Z., Free PMC Article | 10/22/2022 |
| The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. | The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR., Free PMC Article | 10/22/2022 |
| Altered expression of TPP1 in fibroblast-like synovial cells might be involved in the pathogenesis of rheumatoid arthritis. | Altered expression of TPP1 in fibroblast-like synovial cells might be involved in the pathogenesis of rheumatoid arthritis.
Qing YF, Zhou JG, Zhao MC, Xie WG, Yang QB, Xing Y, Zeng SP, Jiang H. | 10/22/2022 |
| Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication. | Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication.
Chawla R, Redon S, Raftopoulou C, Wischnewski H, Gagos S, Azzalin CM., Free PMC Article | 10/22/2022 |
| Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA. | Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA.
Taylor DJ, Podell ER, Taatjes DJ, Cech TR., Free PMC Article | 10/22/2022 |
| Human telomere POT1-TPP1 complex and its role in telomerase activity regulation. | Human telomere POT1-TPP1 complex and its role in telomerase activity regulation.
Wang F, Lei M. | 10/22/2022 |