| The yes-associated protein (YAP) is associated with resistance to anti-GD2 immunotherapy in neuroblastoma through downregulation of ST8SIA1. | The yes-associated protein (YAP) is associated with resistance to anti-GD2 immunotherapy in neuroblastoma through downregulation of ST8SIA1.
Pilgrim AA, Jonus HC, Ho A, Cole AC, Shim J, Goldsmith KC., Free PMC Article | 08/10/2023 |
| Possible regulation of ganglioside GD3 synthase gene expression with DNA methylation in human glioma cells. | Possible regulation of ganglioside GD3 synthase gene expression with DNA methylation in human glioma cells.
Yamamoto Y, Higashimoto K, Ohkawa Y, Soejima H, Kaneko K, Ohmi Y, Furukawa K, Furukawa K. | 05/25/2023 |
| Long noncoding RNA NR2F1-AS1 plays a carcinogenic role in gastric cancer by recruiting transcriptional factor SPI1 to upregulate ST8SIA1 expression. | Long noncoding RNA NR2F1-AS1 plays a carcinogenic role in gastric cancer by recruiting transcriptional factor SPI1 to upregulate ST8SIA1 expression.
Zuo F, Zhang Y, Li J, Yang S, Chen X., Free PMC Article | 02/19/2022 |
| BACH1 Binding Links the Genetic Risk for Severe Periodontitis with ST8SIA1. | BACH1 Binding Links the Genetic Risk for Severe Periodontitis with ST8SIA1.
Chopra A, Mueller R, Weiner J 3rd, Rosowski J, Dommisch H, Grohmann E, Schaefer AS., Free PMC Article | 02/5/2022 |
| Knockdown of lncRNA MIR44352HG and ST8SIA1 expression inhibits the proliferation, invasion and migration of prostate cancer cells in vitro and in vivo by blocking the activation of the FAK/AKT/betacatenin signaling pathway. | Knockdown of lncRNA MIR4435‑2HG and ST8SIA1 expression inhibits the proliferation, invasion and migration of prostate cancer cells in vitro and in vivo by blocking the activation of the FAK/AKT/β‑catenin signaling pathway.
Xing P, Wang Y, Zhang L, Ma C, Lu J., Free PMC Article | 11/22/2021 |
| ST8SIA1 inhibition sensitizes triple negative breast cancer to chemotherapy via suppressing Wnt/beta-catenin and FAK/Akt/mTOR. | ST8SIA1 inhibition sensitizes triple negative breast cancer to chemotherapy via suppressing Wnt/β-catenin and FAK/Akt/mTOR.
Wan H, Li Z, Wang H, Cai F, Wang L. | 09/18/2021 |
| Comprehensive Transcriptomic Analysis Identifies ST8SIA1 as a Survival-Related Sialyltransferase Gene in Breast Cancer. | Comprehensive Transcriptomic Analysis Identifies ST8SIA1 as a Survival-Related Sialyltransferase Gene in Breast Cancer.
Kan JY, Moi SH, Hung WC, Hou MF, Chen FM, Shih SL, Shiau JP, Li CL, Chiang CP., Free PMC Article | 07/24/2021 |
| TNFalpha-signal and cAMP-mediated signals oppositely regulate melanoma- associated ganglioside GD3 synthase gene in human melanocytes. | TNFα-signal and cAMP-mediated signals oppositely regulate melanoma- associated ganglioside GD3 synthase gene in human melanocytes.
Takeuchi R, Kambe M, Miyata M, Jeyadevan U, Tajima O, Furukawa K, Furukawa K., Free PMC Article | 10/31/2020 |
| genetic variants at the genes SSH1 and ST8SIA1 were related to the genetic predisposition to early-onset periodontitis that is in part triggered by smoking | Smoking Modifies the Genetic Risk for Early-Onset Periodontitis.
Freitag-Wolf S, Munz M, Wiehe R, Junge O, Graetz C, Jockel-Schneider Y, Staufenbiel I, Bruckmann C, Lieb W, Franke A, Loos BG, Jepsen S, Dommisch H, Schaefer AS. | 07/25/2020 |
| these data demonstrate the mechanism by which ST8SIA1 regulates tumor growth and metastasis in triple-negative breast cancer. | ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK-AKT-mTOR Signaling Pathway.
Nguyen K, Yan Y, Yuan B, Dasgupta A, Sun J, Mu H, Do KA, Ueno NT, Andreeff M, Battula VL., Free PMC Article | 09/14/2019 |
| These results suggest that curcumin controls hST8Sia I gene expression via AMPK signal pathway in A549 cells. | Transcriptional Activation of Human GD3 Synthase (hST8Sia I) Gene in Curcumin-Induced Autophagy in A549 Human Lung Carcinoma Cells.
Lee M, Kim KS, Fukushi A, Kim DH, Kim CH, Lee YC., Free PMC Article | 10/27/2018 |
| These results from genotype-phenotype analysis might suggest a possible link between the ST8SIA1 functional promoter haplotype and the clinical severity of TAO [thyroid-associated ophthalmopathy]. | Identification and Functional Characterization of ST3GAL5 and ST8SIA1 Variants in Patients with Thyroid-Associated Ophthalmopathy.
Park HJ, Kim JH, Yoon JS, Choi YJ, Choi YH, Kook KH, Choi JH., Free PMC Article | 12/16/2017 |
| altered expression of miR-33a/let-7e was correlated with ST8SIA1 level, which might contribute to CRC progression | MicroRNA-33a and let-7e inhibit human colorectal cancer progression by targeting ST8SIA1.
Shan Y, Liu Y, Zhao L, Liu B, Li Y, Jia L. | 11/18/2017 |
| Data suggest that ganglioside glycosyltransferases ST3GAL5, ST8SIA1, and B4GALNT1 are S-acylated at conserved cysteine residues located close to cytoplasmic border of their transmembrane domains; ST3Gal-II is acylated at conserved cysteine residue in N-terminal cytoplasmic tail; for B4GALNT1 and ST3Gal-II, dimer formation controls their S-acylation status. | Ganglioside glycosyltransferases are S-acylated at conserved cysteine residues involved in homodimerisation.
Chumpen Ramirez S, Ruggiero FM, Daniotti JL, Valdez Taubas J. | 08/19/2017 |
| GD3 and GD3S are highly expressed in glioblastoma multiforme (GBM) stem cell, play a key role in glioblastoma tumorigenicity, and are potential therapeutic targets against GBM. | Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity.
Yeh SC, Wang PY, Lou YW, Khoo KH, Hsiao M, Hsu TL, Wong CH., Free PMC Article | 12/17/2016 |
| Results show that GD3S regulates stem cell function via c-Met and the expression of GD3S is regulated by FOXC2, a transcription factor functioning downstream of several epithelial-mesenchymal transition signaling pathways. | GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer.
Sarkar TR, Battula VL, Werden SJ, Vijay GV, Ramirez-Peña EQ, Taube JH, Chang JT, Miura N, Porter W, Sphyris N, Andreeff M, Mani SA., Free PMC Article | 08/8/2015 |
| our study provides support for the GD3-induced cell cycle arrest, disruption of integrin-b1-mediated anchorage, inhibition of angiogenesis and thereby induced apoptosis in pancreatic cancer cells. | Disialoganglioside GD3-synthase over expression inhibits survival and angiogenesis of pancreatic cancer cells through cell cycle arrest at S-phase and disruption of integrin-β1-mediated anchorage.
Mandal C, Sarkar S, Chatterjee U, Schwartz-Albiez R, Mandal C. | 04/4/2015 |
| Though results are limited by the small sample size, variants in BDNF and ST8SIA may slow down the early response to antidepressants in subjects non-exposed to stressors at the illness onset, with a remarkable gene-environment interaction | Genes involved in neuroplasticity and stressful life events act on the short-term response to antidepressant treatment: a complex interplay between genetics and environment.
Mandelli L, Emiliani R, Porcelli S, Fabbri C, Albani D, Serretti A. | 03/21/2015 |
| TNF-alpha and IL-6 secreted from keratinocytes enhanced ST8SIA1 expression in melanocytes. | UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor α and interleukin 6.
Miyata M, Ichihara M, Tajima O, Sobue S, Kambe M, Sugiura K, Furukawa K, Furukawa K. | 06/7/2014 |
| This indicates that ST8Sia I is able to act as an oligosialyltransferase in a cellular context. | Accumulation of unusual gangliosides G(Q3) and G(P3) in breast cancer cells expressing the G(D3) synthase.
Steenackers A, Vanbeselaere J, Cazet A, Bobowski M, Rombouts Y, Colomb F, Le Bourhis X, Guérardel Y, Delannoy P., Free PMC Article | 12/29/2012 |
| Results show that G(D3) synthase expression is sufficient to enhance the tumorigenicity of MDA-MB-231 breast cancer cells through a ganglioside-dependent activation of the c-Met receptor. | GD₃ synthase expression enhances proliferation and tumor growth of MDA-MB-231 breast cancer cells through c-Met activation.
Cazet A, Lefebvre J, Adriaenssens E, Julien S, Bobowski M, Grigoriadis A, Tutt A, Tulasne D, Le Bourhis X, Delannoy P. | 02/26/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| GD3 has a role in hypoxia susceptibility by disabling the c-Src/NF-kappaB survival pathway resulting in lower Mn-SOD expression | GD3 synthase overexpression sensitizes hepatocarcinoma cells to hypoxia and reduces tumor growth by suppressing the cSrc/NF-kappaB survival pathway.
Lluis JM, Llacuna L, von Montfort C, Bárcena C, Enrich C, Morales A, Fernandez-Checa JC., Free PMC Article | 05/3/2010 |
| Ganglioside GD3-Synthase was associated with poor pathohistological grading in breast cancer | Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer.
Ruckhäberle E, Karn T, Rody A, Hanker L, Gätje R, Metzler D, Holtrich U, Kaufmann M. | 01/21/2010 |
| G(D3) synthase overexpression may contribute to increasing the malignant properties of breast cancer cells. | GD3 synthase overexpression enhances proliferation and migration of MDA-MB-231 breast cancer cells.
Cazet A, Groux-Degroote S, Teylaert B, Kwon KM, Lehoux S, Slomianny C, Kim CH, Le Bourhis X, Delannoy P. | 01/21/2010 |