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    CCL20 C-C motif chemokine ligand 20 [ Homo sapiens (human) ]

    Gene ID: 6364, updated on 12-Oct-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    we identified HCV-induced CCL20 as a direct pro-angiogenic factor that acts on endothelial CCR6. These results suggest that the CCL20/CCR6 axis contributes to hepatic angiogenesis, promoting the hypervascular state of hepatitis C virus (HCV)-hepatocellular carcinoma (HCC).

    CCL20, a direct-acting pro-angiogenic chemokine induced by hepatitis C virus (HCV): Potential role in HCV-related liver cancer.
    Benkheil M, Van Haele M, Roskams T, Laporte M, Noppen S, Abbasi K, Delang L, Neyts J, Liekens S.

    The serum CCL20 level was significantly elevated in patients with vitiligo. The level of serum CCL20 was higher in active than in the stable stage. Patients with active vitiligo had elevated numbers of circulating Th1/17 cells and Tc1/17 cells, and upregulated expression of CCR6 in PBMCs and lesions.

    Circulating CCL20: A potential biomarker for active vitiligo together with the number of Th1/17 cells.
    Zhang L, Kang Y, Chen S, Wang L, Jiang M, Xiang L.

    CCL20 enhanced doxorubicin resistance of OC cells by regulating ABCB1 expression

    CCL20 Promotes Ovarian Cancer Chemotherapy Resistance by Regulating ABCB1 Expression.
    Su S, Sun X, Zhang Q, Zhang Z, Chen J.

    High CCL20 level is associated with Abdominal Aortic Aneurysm.

    Circulating CCL20 as a New Biomarker of Abdominal Aortic Aneurysm.
    Soto B, Gallastegi-Mozos T, Rodríguez C, Martínez-González J, Escudero JR, Vila L, Camacho M., Free PMC Article

    expression of CCL20, an important inflammatory mediator, is increased in Nonalcoholic fatty liver disease fibrosis.

    CCL20 is up-regulated in non-alcoholic fatty liver disease fibrosis and is produced by hepatic stellate cells in response to fatty acid loading.
    Chu X, Jin Q, Chen H, Wood GC, Petrick A, Strodel W, Gabrielsen J, Benotti P, Mirshahi T, Carey DJ, Still CD, DiStefano JK, Gerhard GS., Free PMC Article

    Elevated CCL20 production by airway smooth muscle cells, possibly resulting from dysregulated expression of the anti-inflammatory miR-146a-5p, may contribute to enhanced mucus production in asthma.

    Profiling of healthy and asthmatic airway smooth muscle cells following interleukin-1β treatment: a novel role for CCL20 in chronic mucus hypersecretion.
    Faiz A, Weckmann M, Tasena H, Vermeulen CJ, Van den Berge M, Ten Hacken NHT, Halayko AJ, Ward JPT, Lee TH, Tjin G, Black JL, Haghi M, Xu CJ, King GG, Farah CS, Oliver BG, Heijink IH, Burgess JK.

    We postulate CCL20 does not activate CCR6 through the canonical two-step/two-site mechanism of chemokine-chemokine receptor activation

    Mutational analysis of CCL20 reveals flexibility of N-terminal amino acid composition and length.
    Riutta SJ, Larsen O, Getschman AE, Rosenkilde MM, Hwang ST, Volkman BF.

    CCL20 can be a novel predictive marker for taxane response, and the blockade of CCL20 or its downstream pathway might reverse the taxane resistance in breast cancer patients.

    CCL20 triggered by chemotherapy hinders the therapeutic efficacy of breast cancer.
    Chen W, Qin Y, Wang D, Zhou L, Liu Y, Chen S, Yin L, Xiao Y, Yao XH, Yang X, Ma W, Chen W, He X, Zhang L, Yang Q, Bian X, Shao ZM, Liu S., Free PMC Article

    CCL20, which is regulated by HuR and secreted into the bone microenvironment, enhances the metastatic ability and bone metastasis of breast cancer cells by stimulating cancer cells and osteoblastic cells in both autocrine and paracrine manners.

    Human antigen R-regulated CCL20 contributes to osteolytic breast cancer bone metastasis.
    Lee SK, Park KK, Kim HJ, Park J, Son SH, Kim KR, Chung WY., Free PMC Article

    CCl20 and CXCL13 synergistically increased B-cell migration form peripheral blood of rheumatoid arthritis patients.

    Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis.
    Armas-González E, Domínguez-Luis MJ, Díaz-Martín A, Arce-Franco M, Castro-Hernández J, Danelon G, Hernández-Hernández V, Bustabad-Reyes S, Cantabrana A, Uguccioni M, Díaz-González F., Free PMC Article

    CCL20 role in glioblastoma.CCL20 expression in astrocytes during hypoxia.CCL20 up-regulates HIF-1alpha through NF-kappaB activation.

    Astrocyte-derived CCL20 reinforces HIF-1-mediated hypoxic responses in glioblastoma by stimulating the CCR6-NF-κB signaling pathway.
    Jin P, Shin SH, Chun YS, Shin HW, Shin YJ, Lee Y, Kim D, Nam DH, Park JW.

    S1P induced the expression of some asthma-related genes, such as ADRB2, PTGER4, and CCL20, in bronchial epithelial cells. The knock-down of SIPR3 suppressed the expression of S1P-inducing CCL20.

    Role of S1P/S1PR3 axis in release of CCL20 from human bronchial epithelial cells.
    Kawa Y, Nagano T, Yoshizaki A, Dokuni R, Katsurada M, Terashita T, Yasuda Y, Umezawa K, Yamamoto M, Kamiryo H, Kobayashi K, Nishimura Y., Free PMC Article

    CCL20 was upregulated in giant cell tumor of bone patients and correlated with tumor progression and poor prognosis. CCL20 recruited mononuclear cells and induced osteoclastogenesis by over-activating the AKT and NF-kappa B signaling pathways.

    Stromal Cell-Derived CCL20 Promotes Tumor Progression and Osteolysis in Giant Cell Tumor of Bone.
    Zhao C, Wang D, Tang L, Zhang Z, Li S, Qian M, Wu Z, Zhou W, Liu M, Luo J, Liu T, Li Z, Xiao J.

    CCL20 may play an important role in the pathogenesis of MS. Both allelic variation of (rs6749704) within CCL20 gene and (rs763780) within IL-17F gene can be considered risk factor for development of MS in Egyptian patients.

    The combined effect of IL-17F and CCL20 gene polymorphism in susceptibility to multiple sclerosis in Egypt.
    El Sharkawi FZ, Ali SA, Hegazy MI, Atya HB.

    These results provide evidence that necrotic cells induce the expression of CCL2/MCP-1 and CCL20/MIP-3alpha in glioblastoma cells through activation of NF-kappaB and AP-1 and facilitate the infiltration of microglia into tumor tissues.

    MCP-1 and MIP-3α Secreted from Necrotic Cell-Treated Glioblastoma Cells Promote Migration/Infiltration of Microglia.
    Jung Y, Ahn SH, Park H, Park SH, Choi K, Choi C, Kang JL, Choi YH.

    CCN1 stimulates CCL20 production in vitro and in vivo, and thus supports the notion that overexpressed CCN1 in hyperproliferating keratinocyte is functionally involved in the recruitment of inflammatory cells to skin lesions affected by psoriasis.

    Cyr61/CCN1 induces CCL20 production by keratinocyte via activating p38 and JNK/AP-1 pathway in psoriasis.
    Li H, Li H, Huo R, Wu P, Shen Z, Xu H, Shen B, Li N.

    Results demonstrated that F. nucleatum ssp. animalis and dysregulated CCL20 protein expression are important factors associated with human colorectal cancer progression.

    <i>Fusobacterium Nucleatum</i> Subspecies <i>Animalis</i> Influences Proinflammatory Cytokine Expression and Monocyte Activation in Human Colorectal Tumors.
    Ye X, Wang R, Bhattacharya R, Boulbes DR, Fan F, Xia L, Adoni H, Ajami NJ, Wong MC, Smith DP, Petrosino JF, Venable S, Qiao W, Baladandayuthapani V, Maru D, Ellis LM.

    There was underexpression of the majority of genes after sunitinib treatment. The lower expression levels of IGFBP1, CCL20, CXCL6 and FGB were confirmed by qRT-PCR in all cases. The downregulation of gene expression leads us to search for methylation as a mechanism of action of the tyrosine kinase inhibitors

    Gene expression profile of renal cell carcinomas after neoadjuvant treatment with sunitinib: new pathways revealed.
    Dzik C, Reis ST, Viana NI, Brito G, Paloppi I, Nahas W, Srougi M, Leite KRM.

    CCL20 contributed to invasion and epithelial-mesenchymal transition of RANK over-expressed endometrial cancer cells

    CCL20 mediates RANK/RANKL-induced epithelial-mesenchymal transition in endometrial cancer cells.
    Liu Y, Wang J, Ni T, Wang L, Wang Y, Sun X., Free PMC Article

    High expression of CCL20 is associated with cutaneous T-cell lymphoma.

    Disruption of CCL20-CCR6 interaction inhibits metastasis of advanced cutaneous T-cell lymphoma.
    Ikeda S, Kitadate A, Ito M, Abe F, Nara M, Watanabe A, Takahashi N, Miyagaki T, Sugaya M, Tagawa H., Free PMC Article

    These results showed that the higher levels of CXCL10, CCL20 and CCL22 were associated with ischemic heart disease. The serum levels of chemokines may influence by the certain traditional risk factors of IHD and some studied SNPs, but did not influence by treatment and gender of patients.

    Higher circulating levels of chemokines CXCL10, CCL20 and CCL22 in patients with ischemic heart disease.
    Safa A, Rashidinejad HR, Khalili M, Dabiri S, Nemati M, Mohammadi MM, Jafarzadeh A.

    The strongest OR was for CXCL8 (interleukin-8) in serum (96.8, 95% CI: 11.9-790.2). Of these 15 markers, 6 were also significantly elevated in serum from Chile (CCL20, C-reactive protein, CXCL8, CXCL10, resistin, serum amyloid A).

    Association of inflammatory and other immune markers with gallbladder cancer: Results from two independent case-control studies.
    Koshiol J, Castro F, Kemp TJ, Gao YT, Roa JC, Wang B, Nogueira L, Araya JC, Shen MC, Rashid A, Hsing AW, Hildesheim A, Ferreccio C, Pfeiffer RM, Pinto LA., Free PMC Article

    mutually exclusive transcriptional regulation by AP-1 (cjun/cfos) and non-canonical NF-kappaB (RelB/p52) downstream of MEK-ERK and NIK-IKK-alpha-NF-kappaB2 (p100) phosphorylation, respectively was responsible for persistent Ccl20 expression in the colonic cells.

    Biphasic Ccl20 regulation by Toll-like receptor 9 through the activation of ERK-AP-1 and non-canonical NF-κB signaling pathways.
    Dutta P, Ta A, Thakur BK, Dasgupta N, Das S.

    CCR6(-) regulatory T cells blunt the restoration of gut Th17 cells along the CCR6-CCL20 axis in treated HIV-1-infected patients.

    CCR6(-) regulatory T cells blunt the restoration of gut Th17 cells along the CCR6-CCL20 axis in treated HIV-1-infected individuals.
    Loiseau C, Requena M, Mavigner M, Cazabat M, Carrere N, Suc B, Barange K, Alric L, Marchou B, Massip P, Izopet J, Delobel P.

    CCL20 provoked a 2.5-fold increase of cell migration and invasion in human cancerous breast epithelial cells ; CCL20 also enhanced MMP- 2 and MMP-9 mRNAs/protein expression and activities.

    CCL20 promotes migration and invasiveness of human cancerous breast epithelial cells in primary culture.
    Muscella A, Vetrugno C, Marsigliante S.

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