HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia. | HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia. Agrawal-Singh S, Bagri J, Giotopoulos G, Azazi DMA, Horton SJ, Lopez CK, Anand S, Bach AS, Stedham F, Antrobus R, Houghton JW, Vassiliou GS, Sasca D, Yun H, Whetton AD, Huntly BJP., | 04/10/2023 |
SKA1 promotes tumor metastasis via SAFB-mediated transcription repression of DUSP6 in clear cell renal cell carcinoma. | SKA1 promotes tumor metastasis via SAFB-mediated transcription repression of DUSP6 in clear cell renal cell carcinoma. Pu Y, Han J, Zhang M, Liu M, Abdusamat G, Liu H., Free PMC Article | 12/31/2022 |
Short-term hypoxia triggers ROS and SAFB mediated nuclear matrix and mRNA splicing remodeling. | Short-term hypoxia triggers ROS and SAFB mediated nuclear matrix and mRNA splicing remodeling. Taze C, Drakouli S, Samiotaki M, Panayotou G, Simos G, Georgatsou E, Mylonis I., Free PMC Article | 12/17/2022 |
Subcellular dynamics of estrogen-related receptors involved in transrepression through interactions with scaffold attachment factor B1. | Subcellular dynamics of estrogen-related receptors involved in transrepression through interactions with scaffold attachment factor B1. Tanida T, Matsuda KI, Uemura T, Yamaguchi T, Hashimoto T, Kawata M, Tanaka M. | 10/23/2021 |
Abnormal scaffold attachment factor 1 expression and localization in spinocerebellar ataxias and Huntington's chorea. | Abnormal scaffold attachment factor 1 expression and localization in spinocerebellar ataxias and Huntington's chorea. Buckner N, Kemp KC, Scott HL, Shi G, Rivers C, Gialeli A, Wong LF, Cordero-LLana O, Allen N, Wilkins A, Uney JB., Free PMC Article | 10/9/2021 |
Inhibition of HSF1 and SAFB Granule Formation Enhances Apoptosis Induced by Heat Stress. | Inhibition of HSF1 and SAFB Granule Formation Enhances Apoptosis Induced by Heat Stress. Watanabe K, Ohtsuki T., Free PMC Article | 06/19/2021 |
Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association. | Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association. Zhou M, Kuruvilla L, Shi X, Viviano S, Ahearn IM, Amendola CR, Su W, Badri S, Mahaffey J, Fehrenbacher N, Skok J, Schlessinger J, Turk BE, Calderwood DA, Philips MR., Free PMC Article | 02/6/2021 |
Depletion of SAFB leads to changes in 3D genome organization. | The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation. Huo X, Ji L, Zhang Y, Lv P, Cao X, Wang Q, Yan Z, Dong S, Du D, Zhang F, Wei G, Liu Y, Wen B. | 04/4/2020 |
SAFB1 binds to the HIV-1 LTR and physically interacts with phosphorylated RNA polymerase II, repressing HIV-1 transcription initiation and elongation. | Scaffold attachment factor B suppresses HIV-1 infection of CD4(+) T cells by preventing binding of RNA polymerase II to HIV-1's long terminal repeat. Ma L, Sun L, Jin X, Xiong SD, Wang JH., Free PMC Article | 02/23/2019 |
SAFB regulated the activity of NF-kappaB signaling in CRC by targeting TAK1 This novel mechanism provides a comprehensive understanding of both SAFB and the NF-kappaB signaling pathway in the progression of CRC and indicates that the SAFB-TAK1-NF-kappaB axis is a potential target for early therapeutic intervention in CRC progression | Downregulation of SAFB Sustains the NF-κB Pathway by Targeting TAK1 during the Progression of Colorectal Cancer. Jiao HL, Ye YP, Yang RW, Sun HY, Wang SY, Wang YX, Xiao ZY, He LQ, Cai JJ, Wei WT, Chen YR, Gu CC, Cai YL, Hu YT, Lai QH, Qiu JF, Liang L, Cao GW, Liao WT, Ding YQ. | 06/23/2018 |
Depletion of SAFB1 reduced FUS's localization to chromatin-bound fraction and splicing activity, suggesting SAFB1 could tether FUS to chromatin compartment thorough N-terminal DNA-binding motif. Moreover, FUS interacts with another nuclear matrix-associated protein, Matrin3. | FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription. Yamaguchi A, Takanashi K., Free PMC Article | 04/28/2018 |
Data suggest that ERH interacts directly in nucleus with C-terminal Arg-Gly-rich region of SAFB1/SAFB2 and this multimer co-localizes in insoluble nuclear fraction; binding of ERH reverses inhibition exerted by SAFB1/SAFB2 on SRPK1. (ERH = enhancer of rudimentary homolog protein; SAFB = scaffold attachment factor B; SRPK1 = splicing kinase SR protein kinase-1) | Enhancer of rudimentary homologue interacts with scaffold attachment factor B at the nuclear matrix to regulate SR protein phosphorylation. Drakouli S, Lyberopoulou A, Papathanassiou M, Mylonis I, Georgatsou E. | 09/30/2017 |
The expression of coding and non-coding genes with SAFB1 cross-link sites was altered by SAFB1 knockdown. The isoform-specific expression of neural cell adhesion molecule (NCAM1) and ASTN2 was influenced by SAFB1. | iCLIP identifies novel roles for SAFB1 in regulating RNA processing and neuronal function. Rivers C, Idris J, Scott H, Rogers M, Lee YB, Gaunt J, Phylactou L, Curk T, Campbell C, Ule J, Norman M, Uney JB., Free PMC Article | 08/27/2016 |
Single depletion of either SAFB1 or SAFB2 leads to an increase in expression of the other SAFB protein. | Unravelling the RNA-Binding Properties of SAFB Proteins in Breast Cancer Cells. Hong E, Best A, Gautrey H, Chin J, Razdan A, Curk T, Elliott DJ, Tyson-Capper AJ., Free PMC Article | 05/14/2016 |
reveals an unexpected role of SUMO-1 and SAFB in the stimulatory coupling of promoter binding, transcription initiation and RNA processing | The chromatin scaffold protein SAFB1 localizes SUMO-1 to the promoters of ribosomal protein genes to facilitate transcription initiation and splicing. Liu HW, Banerjee T, Guan X, Freitas MA, Parvin JD., Free PMC Article | 07/25/2015 |
SAFB1 formed a complex with the histone methyltransferase EZH2. | Scaffold attachment factor B1 regulates the androgen receptor in concert with the growth inhibitory kinase MST1 and the methyltransferase EZH2. Mukhopadhyay NK, Kim J, You S, Morello M, Hager MH, Huang WC, Ramachandran A, Yang J, Cinar B, Rubin MA, Adam RM, Oesterreich S, Di Vizio D, Freeman MR., Free PMC Article | 09/6/2014 |
Data indicate that scaffold attachment factor SAFB1 is transiently recruited to DNA breaks in a poly(ADP-ribose)-polymerase 1- and poly(ADP-ribose)-dependent manner. | The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling. Altmeyer M, Toledo L, Gudjonsson T, Grøfte M, Rask MB, Lukas C, Akimov V, Blagoev B, Bartek J, Lukas J. | 01/18/2014 |
Results indicate that SAFB1 and SAFB2 are crucial repressors for ERalpha dynamics in association with the nuclear matrix and that their synergistic regulation of ERalpha mobility is sufficient for inhibiting ERalpha function. | Scaffold attachment factor B (SAFB)1 and SAFB2 cooperatively inhibit the intranuclear mobility and function of ERα. Hashimoto T, Matsuda K, Kawata M. | 11/17/2012 |
transcriptional repressor SAFB1 is modified by both SUMO1 and SUMO2/3, and this modification is necessary for its full repressive activity. | Co-repressor activity of scaffold attachment factor B1 requires sumoylation. Garee JP, Meyer R, Oesterreich S., Free PMC Article | 08/6/2011 |
Data show that binding of p53 to SAFB1 had a significant functional outcome, since SAFB1 was shown to suppress p53-mediated reporter gene expression. | SAFB1 interacts with and suppresses the transcriptional activity of p53. Peidis P, Voukkalis N, Aggelidou E, Georgatsou E, Hadzopoulou-Cladaras M, Scott RE, Nikolakaki E, Giannakouros T. | 03/19/2011 |
This study shows that low SAFB protein levels predict poor prognosis of breast cancer patients, suggesting critical functions of SAFB1 and SAFB2 in breast cancer cells. | Low SAFB levels are associated with worse outcome in breast cancer patients. Hammerich-Hille S, Bardout VJ, Hilsenbeck SG, Osborne CK, Oesterreich S. | 08/23/2010 |
Study confirms the primary role of SAFB1/SAFB2 as corepressors and also uncovers a previously unknown role for SAFB1 in the regulation of immune genes and in estrogen-mediated repression of genes. | SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells. Hammerich-Hille S, Kaipparettu BA, Tsimelzon A, Creighton CJ, Jiang S, Polo JM, Melnick A, Meyer R, Oesterreich S., Free PMC Article | 04/12/2010 |
The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2. | The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2. Tsianou D, Nikolakaki E, Tzitzira A, Bonanou S, Giannakouros T, Georgatsou E. | 01/21/2010 |
Importance of ERE-BP as an attenuator of normal ERalpha signaling in vivo and is a novel target for modulation by selective estrogen receptor modulators. | Estradiol and tamoxifen mediate rescue of the dominant-negative effects of estrogen response element-binding protein in vivo and in vitro. Chen H, Clemens TL, Hewison M, Adams JS., Free PMC Article | 01/21/2010 |
SAFB1 is not likely to be causative of the hereditary breast cancer syndrome in west Swedish breast cancer families | No germline mutations in supposed tumour suppressor genes SAFB1 and SAFB2 in familial breast cancer with linkage to 19p. Bergman A, Abel F, Behboudi A, Yhr M, Mattsson J, Svensson JH, Karlsson P, Nordling M., Free PMC Article | 01/21/2010 |